Influence of heparin on the assay of amitriptyline, clomipramine, and their metabolites

Therapeutic Drug Monitoring

Volumn 18, Issue 3, 1996, Pages 304-305

  Levering, S C M ^a   Oostelbos, M C J M ^a   Toll, P J M M ^a   Loonen, A J M ^a  

^a JEROEN BOSCH HOSPITAL   (Netherlands)

Author keywords

Drug protein binding; Heparin; Tricyclic antidepressants

Indexed keywords

AMITRIPTYLINE; CLOMIPRAMINE; HEPARIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DRUG BLOOD LEVEL; DRUG PROTEIN BINDING; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN BINDING; RANDOMIZED CONTROLLED TRIAL;

EID: 0029980983     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-199606000-00015     Document Type: Article

References (4)

1. 1-Acid glycoprotein involvement in high affinity binding of tricyclic antidepressants to human plasma. Biochem Pharmacol 1983;32:1149-53.
2. McElnay JC, D'Arcy PF. Protein binding displacement interactions and their clinical importance. Drugs 1983;25:495-513.
3. Lindup WE, L'e Orme MC. Plasma protein binding of drugs. Br Med J 1981;282:212-4.
4. Visser T, Oostelbos MCJM, Toll PJMM. Reliable routine method for the determination of antidepressant drugs in plasma by high-performance liquid chromatography. J Chromatogr 1984;309:81-93.