Use of mathematically enhanced spectral analysis and spectral contrast techniques for the liquid chromatographic and capillary electrophoretic detection and identification of pharmaceutical compounds

Chirality

Volumn 8, Issue 1, 1996, Pages 67-76

  Swartz, Michael E ^a   Brown, Phyllis R ^b  

^a WATERS CORPORATION   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

diastereomers; enantiomers; HPLC; isomers; MECC; method development; peak homogeneity; peak tracking; photodiode array detection; spectral analysis; spectral contrast

Indexed keywords

6 AMINOPENICILLANIC ACID; ACETIC ACID; ACETONITRILE; AMOXICILLIN; DOXEPIN; EPHEDRINE; IMIPRAMINE; METHANOL; NAFCILLIN; NORTRIPTYLINE; ORGANIC SOLVENT; PENICILLIN DERIVATIVE; PROPRANOLOL; PSEUDOEPHEDRINE; TICARCILLIN; TRICYCLIC ANTIDEPRESSANT AGENT; TRIETHYLAMINE;

CHIRALITY; CIS TRANS ISOMERISM; COMPUTER PROGRAM; CONFERENCE PAPER; DIASTEREOISOMER; DRUG IDENTIFICATION; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MATHEMATICAL ANALYSIS; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; PH; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY;

ANTIDEPRESSIVE AGENTS, TRICYCLIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; ELECTROPHORESIS, CAPILLARY; EPHEDRINE; HYDROGEN-ION CONCENTRATION; MOLECULAR CONFORMATION; PENICILLINS; PHARMACEUTICAL PREPARATIONS; STEREOISOMERISM;

EID: 0029980293     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1996)8:1<67::AID-CHIR12>3.0.CO;2-Q     Document Type: Conference Paper

References (20)

1. Wright, A.G., Fell, A.F., Berridge, J.C. Sequential simplex optimization and multichannel detection in HPLC; Application to method development. Chromatographia 24:533-540, 1987.
2. Castel, J.B., Fell, A. F. Strategies for peak purity assessment in liquid chromatography. J. Pharm. Biomed. Anal. 11:1-13, 1993.
3. Ueland, P.M., Kvalheim, G., Lonning, P.E., Kvinnsland, S. Determination of warfarin in human plasma by high performance liquid chromatography and photodiode array detection. Ther. Drug Monitor. 7:329-335, 1985.
4. Brenneisen, R., Mathys, K., Geisshusler, S., Fisch, H.U., Koelbing, U., Kalix, P. Determination of S-(-)-cathinone and its main metabolite R,S-(-)-norephedrine in human plasma by HPLC and photodiode array detection. J. Liq. Chrom. 14:271-286, 1991.
5. Heiger, D.N., Kaltenbach, P., Sievert, H.P. Diode array detection in capillary electrophoresis. Electrophoresis 15:1234-1247, 1994.
6. Tomlinson, A.J., Bensen, L.M., Johnson, K.L., Naylor, S. Investigation of drug metabolism using capillary eleccrophoresis with photodiode array detection and on-line mass spectrometry equipped with an array detector. Electrophoresis 15:62-71, 1994.
7. Schmutz, A., Thormann, W. Factors affecting the determination of drugs and endogenous low molecular mass compounds in human serum by micellar electrokinetic capillary chromatography with direct sample injection. Electrophoresis 15:51-61, 1994.
8. Thormann, W., Meier, P., Marcoh, C., Binder, F. Analysis of barbiturates in human serum and urine by high performance capillary electrophoresis micellar electrokinetic capillary chromatography with on-column multi-wavelength detection. J. Chromatogr. 545:445-460, 1991.
9. Grimm, R, Graf, A., Heiger, D.N. Identification of tryptophan and tyrosine residues in pepetides separated by capillary electrophoresis by their second derivative spectra using diode array detection. J. Chromatogr. A 679:173-180, 1994.
10. Gorenstein, M.V., Li, J.L., Van Antwerp, J., Chapman, D. Detecting coeluting impurities by spectral comparison. LC/GC 12:768-772, 1994.
11. Gilby, A.C., Leveille, M.J. Optical design of a new photodiode array absorbance detector for high perfomance liquid chromatography. Optically Based Methods for Process Analysis 1681:54-66, 1992.
12. Fallick, G, Romano, J. Enhanced photodiode array detection. Am. Lab. February:47BB-47JJ, 1995.
13. Krahn, M.M., Ylitalo, G.M., Buzitus, J., Sloan, C.A., Boyd, D.T., Chan, S.-L., Varanasi, U. Screening for planar chlorobiphenyl congeners in tissues of manne biota by HPLC with photodiode array detection. Chemosphere 29:117-139, 1994.
14. Young, P.M., Gorenstein, M.V. Identifying peptides through mathematically enhanced spectral analysis. GEN 13:17-19, 1993.
15. Young. P. M., Gorenstein, M. V. Tryptic mapping by reverse phase HPLC with photodiode array detection incorporating the spectral contrast technique. LC/GC 12:832-838, 1994.
16. Bouvier, E.S.P., Oehrle, S.A. Analysis and identification of nitroaromatic and nitramine explosives in water using HPLC and PDA detection. LC/GC 13:120-130, 1995.
17. Mazzeo, J.R., Grover, E.R., Swartz, M.E., Petersen, J.S. Novel chiral surfactant for the separation of enantiomers by micellar electrokinetic capillary chromatography. J. Chromatogr. A 680:125-135, 1994.
18. Weinberger, R. Practical Capillary Electrophoresis. Academic Press, Boston, 1993.
19. Camilleri, P, ed. Capillary Electrophoresis Theory and Practice. CRC Press, Boca Raton, 1993.
20. Swarz, M.E. Method development and selectively control for small molecule pharmaceutical separations by capillary electrophoresis. J. Liq. Chrom. 14:923-938, 1991.