Modulation by calcineurin of 5-HT3 receptor function in NG108-15 neuroblastoma x glioma cells

British Journal of Pharmacology

Volumn 118, Issue 7, 1996, Pages 1836-1840

  Boddeke, H W G M ^a,b   Meigel, I ^a,b   Boeijinga, P ^a,b   Arbuckle, J ^a,b   Docherty, R J ^a,b  

^a Preclinical Research   (Switzerland)

^b Sandoz Institute for Medical Research   (United Kingdom)

Author keywords

5 HT3 receptors; Calcineurin; NG108 15 cells; Receptor desensitization

Indexed keywords

CALCINEURIN; CALCIUM; CYCLOPHILIN A; CYCLOSPORIN A; EGTAZIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN KINASE INHIBITOR; SEROTONIN 3 RECEPTOR; STAUROSPORINE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; GLIOMA CELL; HALF LIFE TIME; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; TIME; VOLTAGE CLAMP;

EID: 0029980253     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15611.x     Document Type: Article

References (20)

1. 3 receptors in NG108-15 neuroblastoma × glioma hybrid cells. J. Physiol., 473, 267P.
2. 2+-activated phosphatase in mammalian brain. Trends Neurosci., 12, 117-122.
3. BIALOJAN, C. & TAKAI, A. (1988). Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Biochem. J., 256, 283-290.
4. CHAD, J.E. & ECKERT, R. (1986). An enzymatic mechanism for calcium current inactivation in Helix neurones. J. Physiol., 378, 31-52.
5. A receptor function is regulated by phosphorylation in acutely dissociated guinea-pig hippocampal neurones. J. Physiol., 420, 207-22.
6. DOCHERTY, R.J., ROBBINS, J. & BROWN, D.A. (1991). NG108-15 neuroblastoma × glioma hybrid cell line as a model neuronal system. In Cellular Neurobiology: a Practical Approach, ed. Chad, J. & Wheal, H. Oxford: IRL Press, p. 75-120.
7. HUGANIR, R.L. & GREENGARD, P. (1983). cAMP-dependent protein kinase phosphorylates the nicotinic acetylcholine receptor. Proc. Natl. Acad. Sci. U.S.A., 80, 1130-1134.
8. KIRKNESS, E.F., BOVENKERK, C.F., UEDA, T. & TURNER, A.J. (1989). Phosphorylation of τ-aminobutyrate (GABA)/benzodiazepine receptors by cyclic AMP-dependent protein kinase. Biochem. J., 259, 613-616.
9. 2+-dependent phosphatases. Nature, 369, 235-239.
10. LINDEN, D.J., DICKINSON, M.H., SMEYNE, M. & CONNOR, J.A. (1991). A long-term depression of AMPA currents in cultured cerebellar purkinje neurons. Neuron, 7, 81-89.
11. LIU, J., FARMER. J.D., LANE, W.S., FRIEDMAN, J., WEISSMAN, I. & SCHREIBER, S.L. (1991). Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell, 66, 807-815.
12. MACDONALD, J.F., MODY, I. & SALTER, M.W. (1989). Regulation of N-methyl-D-aspartate receptors revealed by intracellular dialysis of murine neurones in culture. J. Physiol., 414, 17-34.
13. 3 receptor, a serotonin-gated ion channel. Science. 254, 432-437.
14. 3 receptor-induced currents in NE-115 neuroblastoma cells. Eur. J. Pharmacol., 151, 491-495.
15. 3 receptor-gated currents in adult rat dorsal root ganglion neurones. Br. J. Pharmacol., 102, 272-276.
16. TSIEN, R.Y. (1980). New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis and properties of prototype structures. Biochemistry, 16, 2396-2404.
17. 3 receptors mediate rapid responses in cultured hippocampus and a clonal cell line. Neuron, I, 615-621.
18. YAKEL, J.L., LAGRUTTA, A., ADELMAN. J.P. & NORTH, R.A. (1993). Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes. Proc. Natl. Acad. Sci. U.S.A., 90, 5030-5033.
19. YANG, J. (1990). Ion permeation through 5-hydroxytryptamine-gated channels in Neuroblastoma N18 cells. J. Gen. Physiol., 96, 1177-1198.
20. YEATS, J.C., BODDEKE. H.W.G.M. & DOCHERTY, R.J. (1992). Capsaicin desensitization in rat dorsal root ganglion neurones is due to activation of calcineurin. Br. J. Pharmacol., 107, 238P.