Classical conditioning of the human flexion reflex

Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control

Volumn 101, Issue 3, 1996, Pages 219-225

  Kolb, F P ^a   Timmann, D ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Classical conditioning; Flexion reflex; Human study; Motor learning

Indexed keywords

ADULT; ARTICLE; CONDITIONING; CONTROLLED STUDY; EYELID REFLEX; FEMALE; FLEXOR REFLEX; HUMAN; HUMAN EXPERIMENT; LEARNING; LIMB MOVEMENT; MALE; MUSCLE REFLEX; NORMAL HUMAN; PRIORITY JOURNAL; VOLUNTEER;

EID: 0029980034     PISSN: 0924980X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0924-980X(96)95600-3     Document Type: Article

References (27)

1. Bracha, V., Webster, M.L., Winters, N.K., Irwin, K.B. and Bloedel, J.R. Effects of muscimol inactivation of the cerebellar interposeddentate nuclear complex on the performance of the nictitating membrane response in the rabbit. Exp. Brain Res., 1994, 100: 453-468.
2. Daum, I., Schugens, M.M., Ackermann, H., Lutzenberger, W., Dichgans, J. and Birbaumer, N. Classical conditioning after cerebellar lesions in humans. Behav. Neurosci., 1993, 107: 748-756.
3. Fanardijan, V.V. The influence of cerebellar ablation of conditioned motor reflexes in dogs. In: J.P. Welsh, J.A. Harvey and G.G. Champe (Eds.). Zh. Vyssh. Nerv. Deyat. Pavlova, 1961, 920-926.
4. Gambaryan, L.S. Conditioned avoidance aeflexes induced in dogs with cerebellar lesions. Physiol. Bohemoslovenica, 1960, 9: 261-266.
5. Gordon, J. Spinal mechanisms of motor coordination. In: E.R. Kandel J.H. Schwartz and T.H. Jessell (Eds.), Principles of Neural Sciences, 3rd edn., Appleton and Lange, CT, 1991, pp. 582-595.
6. Gormezano, I. and Kehoe, E.J. Classical conditioning: some methodological-conceptual issues. In: W.K. Estes (Ed.), Handbook of Learning and Cognitive Processes, Vol. 2. Condition and Behavior Theory. Lawrence Erlbaum, Hillsdale, NJ, 1975, pp. 143-179.
7. Gruart, A. and Delgado-García, J.M. Discharge of identified deep cerebellar nuclei neurons related to eye blinks in the alert cat. Neuroscience, 1994, 61: 665-681.
8. Kelly, T.M., Zuo, C.C. and Bloedel, J.R. Classical conditioning of the eyeblink reflex in the decerebrate-decerebellate rabbit. Behav. Brain Res., 1990, 38: 7-18.
9. Kolb, F.P., Irwin, K.B., Winters, N.K., Bloedel, J.R. and Bracha, V. Involvement of the cat cerebellar interposed nucleus in the control of conditioned and unconditioned withdrawal reflexes. Soc. Neurosci. Abstr., 1994, 20: 712.2, 1746.
10. Kolb, F.P., Timmann, D., Weiller, C., Faiss, J. Do parameters of conditioning of the human flexion reflex provide information about motor learning in the cerebellum? Pflügers Arch., 429; Eur. J. Physiol., 1995, Suppl. 1:R39-R107.
11. Kolb, F.P., Timmann, D., Weiller, C., Faiss, J. Do parameters of conditioning of the human flexion reflex provide information about motor learning in the cerebellum? Pflügers Arch., 429; Eur. J. Physiol., 1995, Suppl. 1:R39-R107.
12. Lavond, D.G., Kim, J.J. and Thompson, R.F. Mammalian brain substrates of aversive classical conditioning. Annu. Rev. Psychol., 1993, 44: 317-342.
13. Lye, R.H., O'Boyle, D.J., Ramsden, R.T. and Schady, W. Effects of a unilateral cerebellar lesion on the acquisition of eye-blink conditioning in man. J. Physiol. (London), 1988, 403: 58P.
14. Meinck, H.-M., Benecke, R., Kuester, S. and Conrad, B. Cutaneomuscular (flexor) reflex organisation in normal man and in patients with motor disorders. In: J.E. Desmedt (Ed.), Mechanisms in Health and Disease. Raven Press, New York, 1983, pp. 787-796.
15. Papka, M., Ivry, R. and Woodruff-Pak, D.S. Eyeblink classical conditioning and time production in patients with cerebellar damage. Soc. Neurosci. Abstr., 1994, 20: 154.1, 360.
16. Perrett, S.P., Ruiz, B.P. and Mauk, M.D. Cerebellar cortex lesions disrupt learning-dependent timing of conditioned eyelid responses. J. Neurosci., 1993, 13: 1708-1718.
17. Popov, N.F. The role of the cerebellum in the formation of conditioned motor reflexes. In: D.S. Fursikov, M.O. Gurevich and A.N. Zalmanzon (Eds.), Vishaya N'ervnaya D'eyatel'nost: Sbornik Trudov Instituta. Komunisticheskaya Akademija Institutvishey Nervnoy D'eyatel'nosti, 1929, pp. 140-148.
18. Shahani, B.T. and Young, R.R. Human flexor reflexes. J. Neurosurg., 1971, 34: 616-627.
19. Solomon, P.R., Stowe, G.T. and Pendlbeury, W.W. Disrupted eyelid conditioning in a patient with damage to cerebellar afferents. Behav. Neurosci., 1989, 103: 898-902.
20. Timmann, D., Plummer, C., Schwarz, M. and Diener, H.C. Influence of flupirtine on human lower limb reflexes. Electroenceph. clin. Neurophysiol., 1995, 97: 184-188.
21. Topka, H., Valls-Solé, J., Massaquoi, S.G. and Hallett, M. Deficit in classical conditioning in patients with cerebellar degeneration. Brain, 1993, 116: 961-969.
22. Voneida, T.J., Christie, D., Bogdanski, R. and Chopko, B. Changes in instrumentally and classically conditioned limb-flexion responses following inferior olivary lesions and olivocerebellar tractotomy in the cat. J. Neurosci. 1990, 10: 3583-3593.
23. Welsh, J.P. and Harvey, J.A. Cerebellar lesions and the nictitating membrane reflex: performance deficits of the conditioned and unconditioned response. J. Neurosci., 1989, 9: 299-311.
24. Welsh, J.P. and Harvey, J.A. Pavlovian conditioning in the rabbit during inactivation of the interpositus nucleus. J. Physiol., 1991, 444: 459-480.
25. Woodruff-Pak, D.S. and Thompson, R.F. Classical conditioning of the eyeblink response in the delay paradigm in adults aged 18-83 years. Psychol. Aging, 1988, 3: 219-229.
26. Woodruff-Pak, D.S., Finkbiner, R.G. and Katz, I.R. A model system demonstrating parallels in animal and human aging. In: E.M. Meyer, J.W. Simpkins and J. Yamamotot (Eds.), Novel Approaches to the Treatment of Alzheimer's Disease. Plenum Press, New York, 1989, pp. 317-342.
27. Woodruff-Pak, D.S., Logan, G.L. and Thompson, R.F. Neurobiological substrates of classical conditioning across the life span. Ann. N. Y. Acad. Sci., 1990, 608: 150-173.