Gene targeting approaches to analyse neurotransmitter receptor function

Seminars in Neuroscience

Volumn 8, Issue 3, 1996, Pages 145-152

  Tecott, Laurence H ^a   Brennan, Thomas J ^a   Guh, Lucia ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Gene targeting; Knockout; Molecular pharmacology; Neurotransmitter; Receptor

Indexed keywords

NEUROTRANSMITTER RECEPTOR; RECEPTOR SUBTYPE;

ARTICLE; BEHAVIOR; DRUG MECHANISM; GENE TARGETING; MOUSE; MOUSE STRAIN; MUTANT; NERVE CELL DIFFERENTIATION; NONHUMAN; PHYSIOLOGY; RECEPTOR GENE;

EID: 0029979999     PISSN: 10445765     EISSN: None     Source Type: Journal    
DOI: 10.1006/smns.1996.0019     Document Type: Article

References (63)

1. Capecchi MR (1989) Altering the genome by homologous recombination. Science 244:1288-1292
2. Brandon EP, Idzerda RL, McKnight GS (1995) Targeting the mouse genome: a compendium of knockouts (part 1). Curr Biol 5:625-634
3. Hoyer D, Clarke DE, Fozard JR, et al (1994) International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev 46:157-203
4. Saudou F, Amara DA, Dierich A, et al (1994) Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science 265:1875-1878
5. Tecott LH, Sun LM, Akana SF, et al (1995) Eating disorder and epilepsy in mice lacking 5HT2C serotonin receptors. Nature 374:542-546
6. Pazos A, Palacios JM (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res 346:205-230
7. Boschert U, Amara DA, Segu L, Hen R (1993) Neurosci 58:167
8. Engel G, Gothert M, Hoyer D, Schlicker E, Hilenbrand K (1986) Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex 5-HT1B binding sites. Naunyn Schm Arch Pharmacol 332:1-7
9. Maura G, Raiteri M (1986) Cholinergic terminals in rat hippocampus possess 5-HT1B receptors mediating inhibition of acetylcholine release. Eur J Pharm 129:333-337
10. Hoyer D, Middlemiss DN (1989) The pharmacology of the terminal 5-HT autoreceptors in mammalian brain: evidence for species differences. Trends Pharmacol Sci 10:130-132
11. Molineaux S, Jessell T, Axel R, Julius D (1989) 5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system. Proc Natl Acad Sci USA 86:6793-6797
12. Pompeiano M, Palacios JM, Mengod G (1994) Distribution of the serotonin 5-HT2 receptor subfamily mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Mol Brain Res 23:163-178
13. Kennett GA, Curzon G (1991) Potencies of antagonists indicate that 5-HT1c receptors mediate 1-3(chlorophenyl) piperazine-induced hypophagia. Br J Pharmacol 103:2016-2020
14. Civelli O, Bunzow JR, Grandy DK (1993) Molecular diversity of the dopamine receptors. Annu Rev Pharmacol Toxicol 332:281-307
15. Gingrich JA, Caron MG (1993) Recent advances in the molecular biology of dopamine receptors. Annu Rev Neurosci 16:299-321
16. White FJ (1987) D-1 dopamine receptor stimulation enables the inhibition of nucleus accumbens neurons by a D-2 receptor agonist. Eur J Pharmacol 135:101-105
17. Paul MI, Graybiel AM, David JC, Robertson HA (1992) D1-like and D2-like dopamine receptors synergistically activate rotation and c-fos expression in the dopamine-depleted striatum in a rat model of Parkinson's disease. J Neurosci 12:3729-3742
18. Xu M, Moratalla R, Gold LH, et al (1994) Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell 79:729-742
19. Drago J, Gerfen CR, Lachowicz JE, et al (1994) Altered striatal function in a mutant mouse lacking D1A dopamine receptors. Proc Natl Acad Sci, USA 91:12564-12568
20. Xu M, Hu XT, Moratalla R, Graybiel AM, White FJ, Tonegawa S (1994) Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice. Cell 79:945-955
21. White FJ (1990) Electrophysiological basis of the reinforcing effects of cocaine. Behav Pharmacol 1:303-315
22. Koob GF (1992) Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci 13:177-184
23. Link RE, Stevens MS, Kulatunga M, Scheinen M, Barsh GS, Kobilka BK (1995) Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog Mol Pharmacol 48:48-55
24. Nicholas AP, Pieribone B, Hokfelt T (1993) Distributions of mRNAs for alpha-2 adrenergic receptor subtypes in rat brain: an in situ hybridization study. J Comp Neurol 328:575-594
25. Bylund DB (1988) Subtypes of alpha-2 adrenoceptors: pharmacological and molecular biological evidence converge. Trends Pharmacol Sci 9:356-361
26. Zheng F, Gallagher JP (1992) Metabotropic glutamate receptors are required for the induction of LTP. Neuron 9:163-172
27. Bliss TVP, Collingridge GL (1993) Asynaptic model of memory: a long-term potentiation in the hippocampus. Nature 361:31-39
28. Bashir ZI, Jane DE, Sunter DC, Watkins JC, Collingridge GL (1993) Metabotropic glutamate receptors contribute to the induction of long-term depression in the CA1 region of the hippocampus. Eur J Pharmacol 239:265-266
29. Bolshakov VY, Siegelbaum SA (1994) Postsynaptic induction and presynaptic expression of hippocampal long-term depression. Science 264:1148-1152
30. Nakanishi S (1994) Metabotropic glutamate receptors: synaptic transmission, modulation, and plasticity. Neuron 13:1031-1037
31. Aiba A, Kano M, Chen C, et al (1994) Deficient cerebellar longterm depression and impaired motor learning in mGLuR1 mutant mice. Cell 79:377-388
32. Conquet F, Bashir ZI, Davies CH, et al (1994) Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature 372:237-243
33. Masu M, Iwakabe H, Tagawa Y, et al (1995) Specific deficit of the ON response in visual transmission by targeted disruption of the mGLuR6 gene. Cell 80:757-765
34. Shigemoto R, Nakanishi S, Mizuno N (1992) Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing rat. J Comp Neurol 322:121-135
35. Aiba A, Chen C, Herrup K, Rosenmund C, Stevens CF, Tonegawa S (1994) Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell 79:365-375
36. Bannerman DM, Good MA, Butcher SP, Ramsay M, Morris RGM (1995) Distinct components of spatial learning revealed by prior training and NMDA receptor blockade. Nature 378:182-186
37. Saucier D, Cain DP (1995) Spatial learning without NMDA receptor-dependent long term potentiation. Nature 378:186-189
38. Ito M (1989) Long-term depression. Annu Rev Neurosci 12:85-102
39. Shigemoto R, Abe T, Nomura S, Nakanishi S, Hirano T (1994) Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells. Neuron 12:1245-1255
40. Nakajima Y, Iwakabe H, Akazawa C, et al (1993) Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate. J Biol Chem 268:11868-11873
41. Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, Nakanishi S (1994) Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. Cell 77:361-369
42. Akazawa C, Ohishi H, Nakajima Y, et al (1994) Expression of mRNA's of L-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. Neurosci Lett 171:52-54
43. Unwin N (1993) Neurotransmitter action: Opening of ligandgated ion channels. Cell, Vol 72/Neuron, Vol 10 (Suppl). 31-41
44. Li Y, Erzurumlu RS, Chen C, Jhaveri S, Tonegawa S (1994) Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice. Cell 76:427-437
45. Forrest D, Yuzaki M, Soares HD, et al (1994) Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death. Neuron 13:325-338
46. Sakimura K, Kutsuwada T, Ito I et al (1995) Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature 373:151-155
47. Moriyoshi K, Masu M, Ishii T, Shigemoto R, Mizuno N, Nakanishi S (1991) Molecular cloning and characterization of the rat NMDA receptor. Nature 354:31-37
48. Kutsuwada T, Kashiwabuchi N, Mori H, et al (1992) Molecular diversity of the NMDA receptor channel. Nature 358:36-41
49. Monyer H, Sprengel R, et al (1992) Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256:1217-1221
50. Ishii T, Moriyoshi K, Sugihara H, et al (1993) Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J Biol Chem 268:2836-2843
51. Woolsey TA (1990) Peripheral alteration and somatosensory development, in Development of Sensory Systems in Mammals (Coleman EJ, ed) pp 461-516. Wiley, New York
52. Picciotto MR, Zoli M, Lena C, et al (1995) Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature 374:65-67
53. Sargent P (1993) The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci 16:403-443
54. Gunther U, Benson J, Benke D, et al (1995) Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci, USA 92:7749-7753
55. Wisden W, Seeburg P (1992) GABAA receptor channels: from subunits to functional entities. Curr Opin Neurobiol 2:263-269
56. Macdonald R, Olsen R (1994) GABAA receptor channels. Annu Rev Neurosci 17:569-602
57. Mohler H, Knoflach F, Paysan J, et al (1995) Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation. Neurochem Res 20:631-636
58. Pritchett D, Sontheimer H, Shivers B, et al (1989) Importance of a novel GABAA receptor subunit for benzodiazapine pharmacology. Nature 338:582-585
59. Malherbe P, Sigel E, Baur R, Persohn E, Richards J, Mohler H (1990) Functional characteristics and sites of gene expression of the alpha 1, beta 1, gamma 2-isoform of the rat GABAA receptor. J Neurosci 10:2330-2337
60. Ozaki HS, Wahlsten D (1993) Cortical axon trajectories and growth cone morphologies in fetuses of acallosal mouse strains. J Comp Neurol 336:595-604
61. Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K (1994) Deletion of DNA polymerase B gene segment in T cells using cell type-specific gene targeting. Science 265:103-106
62. Furth PA, Onge L, Boger H, et al (1994) Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci 91:9302-9306
63. Gossen M, Freundlieb S, Bender G, Muller G, Hillen W, Bujard H (1995) Transcriptional activation by tetracyclines in mammalian cells. Science 268:1766-1769