D-glucaric acid content of various fruits and vegetables and cholesterol-lowering effects of dietary D-glucarate in the rat

Nutrition Research

Volumn 16, Issue 4, 1996, Pages 673-681

  Walaszek, Zbigniew ^a   Szemraj, Janusz ^b   Hanausek, Malgorzata ^b   Adams, Alan K ^a,b   Sherman, Ute ^b  

^a Biomedical Horizons Institute   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Calcium D Glucarate; D Glucaric acid; Potassium Hydrogen D Glucarate; Rats; Serum Cholesterol

Indexed keywords

BRASSICA OLERACEA VAR. BOTRYTIS; LACTUCA; MAMMALIA; VITACEAE;

CHOLESTEROL; SACCHARIC ACID; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; APPLE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; FOOD COMPOSITION; FRUIT; GRAPE; HYPERCHOLESTEROLEMIA; LETTUCE; NONHUMAN; PRIORITY JOURNAL; RAT; TRIACYLGLYCEROL BLOOD LEVEL; VEGETABLE;

EID: 0029979194     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/0271-5317(96)00045-0     Document Type: Article

References (28)

1. Marsh CA. Metabolism of D-glucuronolactone in mammalian systems. II. Conversion of D-glucuronolactone into D-glucaric acid by tissue preparation. Biochem J 1963; 87: 82-90.
2. Gorter MK. Note sur les acides chlorogenique at saccharique dans le latex. Rec Trav Chim 1912; 31: 281-286.
3. Kessler G, Neufeld E, Feingold DS, Hassid WZ. Metabolism of D-glucuronic acid and D-galacturonic acid in Phaseolus aureus seedlings. J Biol Chem 1961; 236: 308-312.
4. Dittrich P, Kandler O. Biosynthesis of D-glucaric acid in needles of Larix decidua. Z Pflanzen Physiol 1971; 66: 368-371.
5. Kingstad R, Nordal A. Lactone-forming acids in succulent plants. Phytochemistry 1975; 14: 1868-1870.
6. Elliger CA, Lundin RE, and Haddon WF. Caffeyl esters of glucaric acid in Lycopersicon esculentum leaves. Phytochemistry 1981; 20: 1133-1134.
7. Oen H, Vestrheim S. Detection of non-volatile acids in sweet cherry fruits. Acta Agric Scand 1985; 35: 145-152.
8. Risch B, Herrmann K, Wray V. (E)-O-p-cumaroyl-, (E)-O-feruloyl-derivatives of glucaric acid in citrus. Phytochemistry 1988; 27: 3327-3329.
9. Winsnes R. Lactonic acids in the latex of Euphorbium canariensis L. in relation to succulent metabolism: Isolation and characterization of D-glucaric acid. Medd Norsk Farm Selskap 1972; 34: 1-8.
10. Levvy GA, Conchie J. β-Glucuronidase and the hydrolysis of glucuronides. In: Dutton GJ, ed. Glucuronic Acid: Free and Combined. New York: Academic Press, 1966: 301-364.
11. Horton D, Walaszek Z. Conformation of the D-glucarolactones and D-glucaric acid in solution. Carbohydr Res 1982; 105: 95-109.
12. Marsh CA. Metabolism of D-glucarolactone in mammalian systems: Identification of D-glucaric acid as a normal constituent of urine. Biochem J 1963; 86: 77-86.
13. Dutton, GJ. Glucuronidation of Drugs and Other Compounds. Boca Raton, Fl.: CRC Press, 1980: 83-89.
14. Matsui M, Fukuo A, Watanabe Y, Wanibe T, Okada M. Studies on the glucaric acid pathway in the metabolism of D-glucuronic acid in mammals. IV. Fluorometric method for the determination of D-glucaric acid in serum. Chem Pharm Bull (Tokyo) 1972; 20: 845-848.
15. Colombi A, Maroni M, Antonini C, Fait A, Zocchetti C, Foa V. Influence of sex, age and smoking habits on the urinary excretion of D-glucaric acid. Clin Chim Acta 1983; 128: 349-358.
16. Dohrmann RE. β-Glucuronidase. Berlin, Springer-Verlag: 1969; 6-15.
17. Walaszek Z. Potential use of D-glucaric acid derivatives in cancer prevention. Cancer Lett 1990; 54: 1-8.
18. Walaszek Z. Chemopreventive properties of D-glucaric acid derivatives. Cancer Bull 1993; 45: 453-457.
19. Nigro ND, Campbel RL, Gantt JS, Liu YN, Singh DV. A comparison of the effects of the hypocholesteremic agents cholestyramine and candicidin on the induction of intestinal tumors in rats by azoxymethane. Cancer Res 1977; 37: 3198-3203.
20. Laakso EI, Tokola RA, Hirvisalo EL. Determination of D-glucaric acid by high performance liquid chromatography. J Chromatog 1983; 278: 406-411.
21. Marsh CA. An enzymatic determination of D-glucaric acid by conversion to pyruvate. Anal Biochem 1985; 145: 266-272.
22. Bieri JG. Second Report of the Ad Hoc Committee on Standards for Nutritional Studies. J Nutr 1980; 110: 1726.
23. Mackness MI, Durrington PN. Lipoprotein separation and analysis for clinical studies. In: Converse CA, Skinner ER, eds. Lipoprotein Analysis: A Practical Approach. Oxford: Oxford University Press, 1992: 1-42.
24. Sable-Amplis R, Sicart R, Agid R. Further studies on the cholesterol-lowering effect of apples in humans: Biochemical mechanisms involved. Nutr Res 1983; 3: 325-328.
25. Khachadurian AK. Role of Cholesterol in Atherosclerosis. In: Estahani M, Swaney JB, eds. Advances in Cholesterol Research. Caldwell, NJ: The Telford Press, 1990: 385-420.
26. Kritchevsky D. Cholesterol. New York: J. Wiley, 1958: 177-231.
27. Carr CJ. Effect of feeding potassium acid saccharate in the diet of rats for successive generations. Proc Soc Exp Biol Med 1947; 65, 189-191.
28. Ambrose AM. Acute and chronic toxicity of potassium acid saccharate. J Am Pharm Assoc 1957; 40: 277-279.