The effect of rebamipide on gastric xanthine oxidase activity and type conversion in ethanol-treated rats

Free Radical Biology and Medicine

Volumn 20, Issue 7, 1996, Pages 967-971

  Huh, Keun ^a   Shin, Uk S ^a   Lee, Sang H ^a  

^a Yeungnam University   (South Korea)

Author keywords

Free radicals; Gastric lesion; Lipid peroxidation; Rebamipide; Xanthine oxidase Type conversion

Indexed keywords

ALCOHOL; FREE RADICAL; REBAMIPIDE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; STOMACH HEMORRHAGE; STOMACH MUCOSA; STOMACH ULCER;

EID: 0029979060     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-5849(95)02152-3     Document Type: Article

References (34)

1. Jean, L. M. Oxygen free radicals linked to many diseases. Science 235:529-531; 1987.
2. Perry, M. A.; Wadhwa, S.; Parks, D. A.; Pickard, W.; Granger, D. N. Role of oxygen radicals in ischemic-induced lesion in the cat stomach. Gastroenterology 90:362-367; 1986.
3. Pihan, G.; Regillo, C.; Szabo, S. Free radical and lipid peroxydation in ethanol- or aspirin-induced gastric mucosal injury. Dig. Dis. Sci 32:1395-1401; 1987.
4. Szelenyi, I.; Brune, K. Possible role of oxygen free radicals in ethanol-induced gastric mucosal damage in rats. Dig. Dis. Sci. 33:865-871; 1988.
5. Granger, D. N.; Rutili, G.; Mccord, J. M. Superoxide radicals and feline intestinal schemia. Gastroenterology 81:22-29; 1981.
6. Parks, D. A.; Granger, D. N. Role of xanthine oxidase and hydroxyl radicals. Am. J. Physiol. 245:G285; 1983.
7. Janasch, E. D.; Ground, C.; Bruder, G.; Heid, H. W.; Keenan, T. W.; Franke, W. W. Localization of anthine oxidase in mammary gland epithelium and capillary endothelium. Cell 25:67-82; 1981.
8. Parks, D. A.; Granger, D. N. Xanthine oxidase: Biochemistry, distribution and physiology. Acta Physiol. Scand. Suppl. 548:87-99; 1986.
9. Freeman, B. A.; Crapo, J. D. Biology of disease, free radicals and tissue injury. Lab. Invest. 47:412-426; 1982.
10. Halliwell, B. J.; Gutteridge, H. C. Lipid peroxidation, oxygen radicals, cell damage and antioxidant therapy. Lancet 1:1396-1397; 1984.
11. Joseph, L.; Skibba, R. H.; Stadnicka, P. A.; Kalbfleisch, J. K. Lipid peroxidation caused by hyperthermic perfusion of rat liver. Biochem. Pharmacol. 40:1411-1414; 1990.
12. Kusterer, K.; Pihan, G.; Szabo, S. Role of lipid peroxidation in gastric mucosal lesions induced by HCl, NaOH or ischemia. Am. J. Physiol. 252:G 811-816; 1987.
13. Williams, A. W. Effect of alcohol on gastric mucosa. Br. Med. J. 1:256-259; 1956.
14. Della, C. E.; Stirpe. F. The regulation of rat liver xanthine oxidase, Involvement of thio groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme. Biochem. J. 126:739-745; 1972.
15. Ohkawa, H.; Ohishi, N.; Yagi, K. Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal. Biochem. 95:351-358; 1979.
16. Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275; 1951.
17. Terano, A.; Hiraishi, H.; Ota, S.; Sugimoto, T. Role of superoxide and hydroxyl radicals in rat gastric mucosal injury induced by ethanol. Gastroenterol. Jpn. 24:488-493; 1989.
18. Cho, C. H.; Pfeiffer, C. J.; Mista, H. P. Ulcerogenic mechanism of ethanol and the action of sulphanilyl fluoride on the rat stomach in vivo. J. Pharmacol. 43:495-498; 1991.
19. Hearse, D. J.; Manning, A. S.; Downey, J. D.; Yellon, D. M. Xanthine oxidase: A critical mediator of myocardial injury during ischemia and reperfusion. Acta Physiol. Scand. 548:65-78; 1986.
20. Yamasaki, K.; Kambe, T.; Chijiwa, T.; Ishiyama, H.; Ihorita, S. Gastric mucosal protection by OPC-12759, a novel antiulcer compound in the rat. Eur. J. Pharmacol. 142:23-29; 1987.
21. Oka, S.; Ogino, K.; Horiba, T.; Yoshimura, S.; Yanai, H.; Yamasaki, K.; Okazaki, Y.; Ishiyama, H.; Takemoto, T.; Imaizumi, T.; Kanbe, T. Role of active oxygen species in diethyldithiocarbamate-induced gastric ulcer in the rats. Experientia 46:281-287; 1990.
22. Oka, S.; Ogino, T.; Horiba, T.; Okazaki, Y.; Takemoto, T.; Iida, Y. Effect of various mucosal protection drugs on DDC-induced antral ulcer in rats. Eur. J. Pharmacol. 197:99-102; 1991.
23. Ishiyama, H.; Yamasaki, K.; Imaizumi, T.; Kambe, T.; Ogino, K.; Oka, S.; Takemoto, T. Gastric antral ulcer produced by DDC in rats. J. Clin. Biochem. Nutr. 5:155-163; 1989.
24. Ogino, K.; Hobara, T.; Kawamoto, T.; Kobayashi, H.; Oka, S.; Okazaki. Y. Mechanism of DDC-induced gastric ulcer formation in the rat. Pharmacol. Toxicol. 66:133-137; 1990.
25. Oates, P. J.; Hakkinen, J. P. Studies on the mechanism of ethanol-induced gastric damage in rats. Gastroenterology 94:10-21; 1988.
26. Perry, M. A.; Wadhwa, S.; Parks, D. A.; Granger, D. N. Role of oxygen free radicals in ischemia-induced lesion in the cat stomach. Gastroenterology 90:362-367; 1986.
27. Yoshikawa, T.; Ysuda, M.; Ueda, S.; Naito, Y.; Tanigama, T.; Oyamada, H.; Kondo, M. Vitamin E in gastric mucosal injury induced by ischemia-reperfusion. Am. J. Clin. Nutr. 53:2105-2111; 1991.
28. Itoh, M.; Guth, P. H. Role of oxygen derived free radicals in hemorrhagic shock-induced gastric lesion in the rat. Gastroenterology 88:1162-1167; 1985.
29. Tribble, D. L.; Yee, A. W.; Jones, D. P. The pathophysiological significance of lipid peroxidation in oxidative cell injury. Hepatology 7:377-387; 1987.
30. Sinaceur, J.; Ribiere, C.; Sabourault, D.; Nordamann, R. Superoxide formation in liver mitochondria during ethanol intoxication: Possible role in alcohol hepatotoxicity. In: Poli, G.; Cheeseman, K. H.; Dianzani, M. U.; Slater, T. F., eds. Free radicals in liver injury. Oxford: IRL Press; 1985:175-177.
31. Yoshikawa, T.; Naito, Y.; Tanigawa, T.; Kondo, M. Free radical scavenging activity of the novel antiulcer agent rebamipide studied by electron spin resonance. Arzneimittle-forsch/Drug Res. 43(1):3, 363-366; 1993.
32. Chamber, D. E.; Parks, D. A.; Patterson, G.; Roy, R.; McCord, J. M.; Yoshida, S.; Dawney, J. M. Xanthine oxidase as a source of free radical damage in myocardial ischemia. J. Mol. Cell Cardiol. 17:145-152; 1985.
33. Das, K. D.; Engelman, R. M.; Clement, R.; Otani, H.; Prasad, R.; Rao, P. S. Role of xanthine oxidase inhibitor as free radicals scavenger: A novel mechanism of action of allopurinol and oxypurinol in myocardial salvage. Biochem. Biophys. Res. Commun. 148:314-319; 1987.
34. Kuppsany, P.; Zweier, J. L. Characterization of free radical generation by xanthine oxidase. J. Biol. Chem. 264:9880-9884; 1989.