Results of a randomized trial of granulocyte colony-stimulating factor in patients with infection and severe granulocytopenia

Anti-Cancer Drugs

Volumn 7, Issue 4, 1996, Pages 392-397

  Avilés, Agustin ^a   Guzmän, Renaldo ^a   García, Edna L ^a   Talavera, Alejandra ^a   Díaz Maqueo, José C ^a  

^a HOSPITAL DE ONCOLOGÍA   (Mexico)

Author keywords

Granulocyte colony stimulating factor; Granulocytopenia; Infection; Malignant lymphoma; Multiple myeloma

Indexed keywords

AMIKACIN; ANTIBIOTIC AGENT; CARMUSTINE; CEFTAZIDIME; CYCLOPHOSPHAMIDE; DEXAMETHASONE; EPIRUBICIN; ETOPOSIDE; GRANULOCYTE COLONY STIMULATING FACTOR; IFOSFAMIDE; MELPHALAN; VINCRISTINE;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; FEMALE; GRANULOCYTOPENIA; HEMATOPOIETIC SYSTEM TUMOR; HUMAN; INFECTION; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; MYCOSIS; NEPHROTOXICITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; SUBCUTANEOUS DRUG ADMINISTRATION; SUPERINFECTION; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGRANULOCYTOSIS; AMIKACIN; ANTINEOPLASTIC AGENTS; CEFTAZIDIME; DRUG THERAPY, COMBINATION; FEMALE; GRAM-NEGATIVE BACTERIAL INFECTIONS; GRAM-POSITIVE BACTERIAL INFECTIONS; GRANULOCYTE COLONY-STIMULATING FACTOR; HODGKIN DISEASE; HUMANS; LYMPHOMA; MALE; MIDDLE AGED; MULTIPLE MYELOMA; MYCOSES; PROSPECTIVE STUDIES; SUPERINFECTION;

EID: 0029979048     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-199606000-00003     Document Type: Article

References (16)

1. Hughes WR, Armstrong D, Bodey GP, et al. Guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. J Infect Dis 1990; 161: 381-96.
2. Bodey GP, Buckley M, Sathe YI, et al. Quantitative relationship between circulating leucocytes and infection in patients with acute leukemia. Ann Intern Med 1966; 64: 328-40.
3. Avilés A, Prato CV, Sinco A, et al. Evaluación de dos combinaciones de antimicrobianos para el tratamiento de pacientes con neutropenia e infección. Rev Méd IMSS 1986; 24: 349-54.
4. Avilés A, Prato CV, Pizzuto J. Infecciones en pacientes con granulocitopenia. II. Evaluación de dos programas terapéuticos. Rev Méd IMSS 1987; 25: 11-6.
5. Sawyer DW, Donowitz GR, Mandell P. Polymorphonuclear neutrophils, an effective antimicrobial force. Rev Infect Dis 1986; 11 (suppl 7): S1532-44.
6. Roilides E, Pizzo P. Modulation of host defense by cytokines. Evolving adjuncts in prevention and treatment of serious infections in immunocompromised host. Clin Infect Dis 1993; 15: 508-24.
7. The International Antimicrobial Therapy Cooperative-Group of the European Organization for Research and Treatment of Cancer. Efficacy and toxicity of a single daily dose of amikacin and cefaperazone versus multiple daily doses of amikacin and ceftazidime for infection in patients with cancer and granulocytopenia. Ann Intern Med 1993; 119: 584-93.
8. Lischke GJ, Burguess AW. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. N Engl J Med 1992; 327: 28-35 and 99-106.
9. Biesma P, deVries EG, Willemse PH, et al. Efficacy and tolerability of recombinant human granulocyte colony stimulating factor in patients with chemotherapy related leukopenia and fever. Eur J Cancer 1990; 26: 932-6.
10. Mayordomo JL, Rivera F, Díaz-Puente MT, et al. Decreasing morbidity and cost of treating febrile neutropenia by adding G-CSF or GM-CSF to standard antibiotic therapy. Proc Am Soc Clin Oncol 1993; 12: 437 (abstr).
11. Maher D, Lischke JG, Green M, et al. Filgastrin in patients with chemotherapy induced febrile neutropenia. A double blind placebo controlled trial. Ann Intern Med 1994; 121: 492-501.
12. Endo S, Inada K, Inonue Y, et al. Evaluation of recombinant human granulocyte colony stimulating factor (rhG-CSF) therapy in granulocytopenia patients complicated by sepsis. Curr Ther Res Opin 1994; 13: 233-41.
13. American Society of Clinical Oncology. Recommendations for the use of hematopoietic growth factors. Evidence-base, clinical practice and guidelines. J Clin Oncol 1994; 12: 2471-508.
14. Rose RM. The role of colony-stimulating factors in infectious disease. Current status. Future challenges. Semin Oncol 1992; 19: 415-21.
15. Winston DJ, Ho HG, Bruckner DA, et al. Therapy in febrile granulocytopenic patients. Ann Intern Med 1991; 115: 849-59.
16. Matsumoto M, Matsuhana A, Yokota T. Effects of combination therapy with recombinant human granulocyte colony-stimulating factor (rG-CSF) and antibiotics in neutropenic mice unresponsive to antibiotic alone. J Antimicrob Chemother 1991; 28: 447-53.