Steroid therapy can modulate gut barrier function, host defense, and survival in thermally injured mice

Journal of Surgical Research

Volumn 62, Issue 1, 1996, Pages 53-58

  Gianotti, Luca ^b   Alexander, J Wesley ^a,b   Fukushima, Ryoji ^b   Pyles, Tonyia ^b  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRASTERONE; PREDNISONE; STEROID;

ANIMAL MODEL; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL INFECTION; BURN; CONTROLLED STUDY; CORTICOSTEROID THERAPY; FEMALE; HOST RESISTANCE; INTESTINE MUCOSA; ISOTOPE LABELING; LIVER; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RADIOISOTOPE DISTRIBUTION; SEPSIS; SPLEEN; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029978850     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0172     Document Type: Article

References (31)

1. Gianotti, L., Alexander, J. W., Fukushima, R., and Childress, C. Translocation of Candida albicans is related to the blood flow of individual intestinal villi. Circ. Shock 40: 250-257, 1993.
2. Papa, M., Halperin, Z., Rubinstein, E., Orenstein, A., Gafin, S., and Adar, R. The effect of ischemia of the dog's colon on transmural migration of bacteria and endotoxin. J. Surg. Res. 35: 264-269, 1983.
3. Berg, R. D., and Garlington, A. W. Translocation of certain indigenous bacteria from the gastrointestinal tract of mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect. Immun. 23: 403-411, 1979.
4. Alexander, J. W., Boyce, S. T., Babcock, G. F., Gianotti, L., Peck, M. D., Dunn, D. L., Pyles, T., Childress, C. P., and Ash, S. K. The process of microbial translocation. Ann. Surg. 212(4): 496-512, 1990.
5. Alexander, J. W., Gianotti, L., Pyles, T., Carey, M. A., and Babcock, G. F. Distribution and survival of Escherichia coli translocating from the intestine following thermal injury. Ann. Surg. 213: 558-566, 1991.
6. Deitch, E. A. Bacterial translocation of the gut flora. J. Trauma 30: S184-S189, 1990.
7. Jones, W. G., II, Minei, J. P., Barber, A. E., Rayburn, J. L., Fahey, T. J., III, Shires, T. G., III, and Shires, T. G. Bacterial translocation and intestinal atrophy after thermal injury and burn wound sepsis. Ann. Surg. 211: 399-405, 1990.
8. Gianotti, L., Pyles, T., Alexander, J. W., Carey, M., and Babcock, G. F. Impact of blood transfusion and burn injury on microbial translocation and bacterial survival. Transfusion 32(4): 312-317, 1992.
9. Gianotti, L., Pyles, T., Alexander, J. W., Fukushima, R., Ogle, C. K., and Babcock, G. F. Identification of the blood component responsible for increased susceptibility to gut-derived infection. Transfusion 33: 458-465, 1993.
10. Owens, W. E., and Berg, R. D. Bacterial translocation from the GI tracts of thyrectomized mice. Curr. Microbiol. 7: 169-174, 1982.
11. Berg, R. D. Bacterial translocation from the gastrointestinal tract of mice receiving immunosuppression chemotherapeutic agents. Current Microbiol. 8: 285-292, 1983.
12. Jones, W. G., II, Minei, J. P., Richardson, R. P., Fahey, T. J., III, Calvano, S. E., Antonaccia, A., Shires, G. T., III, and Shires, G. T. Pathophysiologic glucocorticoid elevations promote bacterial translocation after thermal injury. Infect. Immun. 58: 3257-3261, 1990.
13. Daynes, R. A., Dudley, D. J., and Araneo, B. A. Regulation of murine lymphokine production in vivo, II: Dehydroepiandrosterone is a natural enhancer of IL-2 synthesis by helper T cells. Eur. J. Immunol. 20: 793-801, 1990.
14. Stieritz, D. D., and Holder, I. A. Experimental studies of the pathogenesis of infections due to Pseudomonas aeruginosa; description of a burn mouse model. J. Infect. Dis. 131: 688-691, 1978.
15. Wells, C., Maddaus, M. A., and Simmons, R. L. Proposed mechanisms for the translocation of intestinal bacteria. Rev. Inf. Dis. 10: 958-979, 1988.
16. Wilmore, D. W., Smith, R. J., O'Dwyer, S. T., Jacobs, D. A., Ziegler, T. R., and Wang, X. D. The gut: A central organ after surgical stress. Surgery 104: 917-923, 1988.
17. Rush, B. F., Sori, A. J., Murphy, T. F., Smith, S., Flanagan, J. J., and Machiedo, G. W. Endtoxemia and bacteremia during hemorrhagic shock. Ann. Surg. 207: 549-554, 1988.
18. Deitch, E. A. Multiple organ failure. Ann. Surg. 216: 117-134, 1992.
19. Crabtree, G. R., Gillis, S., Smith, K. A., and Munck, A. Glucocorticoids and immune response. Arthritis Rheum. 22: 1246-1256, 1979.
20. Minei, J. P., Fong, M., Marano, A., Moldawer, L. L., Jones, W. G., Wei, H., Richardson, R. P., Yurt, R. W., Shires, T. G., III, Lowry, S. F., and Shires, T. G. Hepatocellular membrane function during chronic burn injury. J. Surg. Res. 46: 311-316, 1989.
21. Mochizuki, H., Trocki, O., Dominioni, L., Brackett, K. A., Joffe, S. N., and Alexander, J. W. Mechanism of prevention of post-burn hypermetabolism and catabolism by early enteral feeding. Ann. Surg. 200: 297-310, 1984.
22. Jones, W. G., II, Barber, A. E., Kapur, S., Hawes, A. J., Fahey, T. J., III, Minei, J. P., Shires, G. T., III, Calvano, S. E., and Shires, G. T. Pathophysiologic glucocorticoid levels and survival of translocating bacteria. Arch. Surg. 126: 50-55, 1991.
23. Gianotti, L., Alexander, J. W., Fukushima, R., and Pyles, T. Reduction of bacterial translocation with oral fibroblast growth factor and sulcrelfate. Am. J. Surg. 165(1): 195-201, 1993.
24. Alverdy, J., and Aoys, E. The effect of glucocorticoid administration on bacteria translocation. Ann. Surg. 214: 719-723, 1991.
25. Daynes, R. A., and Araneo, B. A. Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors, interleukin 2, and interleukin 4. Eur. J. Immunol. 19: 2319-2325, 1989.
26. Waymack, J. P., Robb, E., and Alexander, J. W. Effect of transfusions on immune function in a traumatized animal model. II. Effect on mortality rate following septic challenge. Arch. Surg. 122: 935-939, 1987.
27. Braga, M., Vignali, A., Radaelli, G., Gianotti, L., and Di Carlo, V. Association between perioperative blood transfusion and postoperative infection in patients having elective operations for gastrointestinal cancer. Eur. J. Surg. 158: 531-536, 1992.
28. Tartter, P. I., Quintero, S., and Barron, D. M. Perioperative blood transfusion associated with infectious complications after colorectal cancer operations. Am. J. Surg. 152: 479-482, 1986.
29. Gianotti, L., Alexander, J. W., Pyles, T., and Fukushima, R. Arginine-supplemented diets improve survival in gut-derived sepsis and peritonitis by modulating bacterial clearance: The role of nitric oxide. Ann. Surg. 217(6): 644-654, 1993.
30. Araneo, B. A., Shelby, J., Li, G-Z., Ku, W., and Daynes, R. A. Administration of dehydreoepiandrosterone to burned mice preserves normal immunologic competence. Arch. Surg. 128: 318-325, 1993.
31. Lenhard, V., Maassen, G., Grosse-Wilde, H., Wernet, P., and Opelz, G. Effect of blood transfusion on immunoregulatory mononuclear cells in prospective transplant recipients. Transplant Proc. 15: 1011-1015, 1983.