Cell density-dependent changes in the insulin action pathway: Evidence for involvement of protein-tyrosine phosphatases

Journal of Cellular Biochemistry

Volumn 61, Issue 1, 1996, Pages 31-38

  Li, Pei Ming ^a   Goldstein, Barry J ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b Division of Endocrinology   (United States)

Author keywords

cell density; DNA synthesis; IRS 1 protein; M(r) receptor substrates; tyrosine phosphorylation

Indexed keywords

INSULIN RECEPTOR; PROTEIN TYROSINE PHOSPHATASE;

ARTICLE; CELL DENSITY; CELL GROWTH; DNA SYNTHESIS; ENZYME ACTIVITY; GROWTH CURVE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INSULIN METABOLISM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL COUNT; CELL DIVISION; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS, EXPERIMENTAL; PHOSPHOPROTEINS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; RATS; RECEPTOR, INSULIN; TUMOR CELLS, CULTURED;

EID: 0029978778     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19960401)61:1<31::AID-JCB5>3.0.CO;2-3     Document Type: Article

References (24)

1. Ahmad F, Goldstein BJ (1995a): Alterations in specific protein-tyrosine phosphatases accompany the insulin resistance of streptozotocin-diabetes. Am J Physiol 268:E932-E940.
2. Ahmad F, Li PM, Meyerovitch J, Goldstein BJ (1995b): Osmotic loading of neutralizing antibodies defines a role for protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway. J Biol Chem 270:20503-20508.
3. Araki E, Lipes MA, Patti ME, Bruning JC, Haag B, Johnson RS, Kahn CR (1994): Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene. Nature 372:186-190.
4. Backer JM, Myers MG, Shoelson SE, Chin DJ, Sun XJ, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J, White MF (1992): Phosphatidylinositol 3′-Kinase Is Activated by Association with IRS-1 During Insulin Stimulation. EMBO J 11:3469-3479.
5. Backer JM, Myers MG, Sun XJ, Chin DJ, Shoelson SE, Miralpeix M, White MF (1993): Association of IRS-1 with the Insulin Receptor and the Phosphatidylinositol 3′-Kinase-Formation of Binary and Ternary Signaling Complexes in Intact Cells. J Biol Chem 268:8204-8212.
6. Bradford MM (1976): A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
7. Goldstein BJ (1993): Regulation of insulin receptor signaling by protein-tyrosine dephosphorylation. Receptor 3:1-15.
8. Goldstein BJ (1996): Protein-tyrosine phosphatases and the regulation of insulin action. In LeRoith D, Olefsky JM, Taylor SI (Eds.), Diabetes Mellitus: A Fundamental and Clinical Text. Philadelphia: Lippincott, in press.
9. Kuhné MR, Pawson T, Lienhard GE, Feng GS (1993): The Insulin Receptor Substrate-1 Associates with the SH2-Containing Phosphotyrosine Phosphatase Syp. J Biol Chem 268:11479-11481.
10. Kulas DT, Zhang WR, Goldstein BJ, Furlanetto RW, Mooney RA (1995). Insulin receptor signaling is augmented by antisense inhibition of the protein-tyrosine phosphatase LAR. J Biol Chem 270:2435-2438.
11. Laemmli EK (1970.): Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
12. Lee JS, Pilch PF (1994): The Insulin Receptor-Structure, Function, and Signaling. Am J Physiol 266:C319-C334.
13. Longo FM, Martignetti JA, Le Beau JM, Zhang JS, Barnes JP, Brosius J (1993) Leukocyte common antigen-related receptor-linked tyrosine phosphatase. Regulation of mRNA expression. J Biol Chem 268:26503-26511.
14. Noguchi T, Matozaki T, Horita K, Fujioka Y, Kasuga M (1994): Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated ras activation. Mol Cell Biol 14:6674-6682.
15. Ostman A, Yang Q, Tonks NK (1994): Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. Proc Natl Acad Sci USA 91:9680-9684.
16. Fallen CJ, Tong PH (1991): Elevation of Membrane Tyrosine Phosphatase Activity in Density-Dependent Growth-Arrested Fibroblasts. Proc Natl Acad Sci USA 88:6996-7000.
17. Ramponi G, Ruggiero M, Raugei G, Berti A, Modesti A, Degl'Innocenti D, Magnelli L, Pazzagli C, Chiarugi VP, Camici G (1992): Overexpression of a synthetic phosphotyrosine protein phosphatase gene inhibits normal and transformed cell growth. Int J Cancer 51:652-656.
18. Rosen OM (1987): After Insulin Binds. Science 237:1452-1458.
19. Skolnik EY, Lee CH, Batzer A, Vicentini LM, Zhou M, Daly R, Myers MJ, Backer JM, Ullrich A, White MF, Schlessinger J (1993): The SH2/SH3 Domain-Containing Protein GRB2 Interacts with Tyrosine-Phosphorylated IRS1 and She-Implications for Insulin Control of Ras Signaling. EMBO J 12:1929-1936.
20. Sun XJ, Crimmins DL, Myers MG, Miralpeix M, White MF (1993): Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol Cell Biol 13:7418-7428.
21. Towbin H, Staehelin T, Gordon J (1979): Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci (USA) 76:4350-4354.
22. White MF, Kahn CR (1994): The insulin signaling system. J Biol Chem 269: 1-4.
23. Xiao S, Rose DW, Sasaoka T, Maegawa H, Burke TR, Roller PP, Shoelson SE, Olefsky JM (1994): Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. J Biol Chem 269:21244-21248.
24. Yamauchi K, Milarski KL, Saltiel AR, Pessin JE (1995): Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. Proc Natl Acad Sci (USA) 92:664-668.