Solid phase synthesis of azabicyclo[4.3.0]nonen-8-one amino acid derivatives via intramolecular Pauson-Khand cyclization

Tetrahedron Letters

Volumn 37, Issue 20, 1996, Pages 3433-3436

  Bolton, Gary L ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STEREOCHEMISTRY; X RAY ANALYSIS;

EID: 0029978630     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00587-4     Document Type: Article

References (26)

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23. 3) data: 4: δ 7.66 (d, J=8Hz, 2H), 7.30 (d, J=8Hz, 2H), 5.98 (s, 1H), 4.88 (br dd, J=5 and 2Hz, 1H)), 4.76 (d, J=14Hz, 1H), 4.20 (d, J=14Hz, 1H), 3.61 (s, 3H), 2.76 (m, 1H), 2.58 (dd, J=19 and 6Hz, 1H), 2.48 (ddd, J=13, 5, and 2Hz, 1H), 2.43 (s, 3H), 1.95 (dd, J=19 and 3Hz, 1H), 1.58 (ddd, J=13,13,and 5Hz, 1H); 5: δ 7.71 (d, J=8Hz, 2H), 7.31 (d, J=8Hz, 2H), 5.97 (s, 1H), 5.11 (d, J=7Hz, 1H), 4.18 (br dd, J=11 and 5Hz, 1H), 3.54 (s, 3H), 3.26 (d, J=14Hz, 1H), 2.91 (m, 2H), 2.79 (dd, J=14 and 7Hz, 1H), 2.51 (dd, J=19 and 6Hz, 1H), 2.43 (s, 3H), 1.91 (dd, J=19 and 2Hz, 1H); 10a: δ 7.52 (d, J=8Hz, 2H), 7.43 (m, 3H), 7.20 (m, 4H), 4.97 (br d, J=4Hz, 1H), 4.92 (d, J=15Hz, 1H), 4.30 (d, J=15Hz, 1H), 3.68 (s, 3H), 2.86 (m, 1H), 2.75 (dd, J=19 and 7Hz, 1H), 2.55 (ddd, J=13, 5, and 2Hz, 1H), 2.42 (s, 3H), 2.07 (dd, J=19 and 3Hz, 1H), 1.60 (ddd, J=13, 13, and 6Hz, 1H).
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