Venous thromboembolism during pregnancy

New England Journal of Medicine

Volumn 335, Issue 2, 1996, Pages 108-114

  Toglia, Marc R ^a   Weg, John G ^b  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; WARFARIN;

DEEP VEIN THROMBOSIS; DELIVERY; DISEASE ASSOCIATION; LABOR; LUNG EMBOLISM; PATHOPHYSIOLOGY; PHLEBOGRAPHY; PREGNANCY; PRIORITY JOURNAL; PROPHYLAXIS; REVIEW; RISK FACTOR; TREATMENT PLANNING; VEIN THROMBOSIS;

FEMALE; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; PULMONARY EMBOLISM; RECURRENCE; THROMBOEMBOLISM; THROMBOPHLEBITIS;

EID: 0029978487     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199607113350207     Document Type: Review

References (70)

1. Rochat RW, Koonin LM, Atrash HK, Jewett JF. Maternal mortality in the United States: report from the Maternal Mortality Collaborative. Obstet Gynecol 1988;72:91-7
2. Franks AL, Atrash HK, Lawson HW, Colberg KS. Obstetrical pulmonary embolism mortality, United States, 1970-85. Am J Public Health 1990;80:720-2.
3. de Swiet M, Fidler J, Howell R, Letsky E. Thromboembolism in pregnancy. In: Jewell D, ed. Advanced medicine. London: Pitman Medical, 1981:309-17.
4. Rutherford S, Montoro M, McGehee W, Strong T. Thromboembolic disease associated with pregnancy: an 11-year review. Am J Obstet Gynecol 1991;164:Suppl:286. abstract.
5. National Institutes of Health Consensus Development Conference. Prevention of venous thrombosis and pulmonary embolism. JAMA 1986;256: 744-9.
6. Goodrich SM, Wood JE. Peripheral venous distensibility and velocity of venous blood flow during pregnancy or during oral contraceptive therapy. Am J Obstet Gynecol 1964;90:740-4.
7. Clarke-Pearson DL, Jelovsek FR. Alterations of occlusive cuff impedance plethysmography results in the obstetric patient. Surgery 1981;89:594-8.
8. Report on confidential inquiries into maternal deaths in England and Wales, 1976-1978. London: Department of Health and Social Security, 1982.
9. Bonnar J. Haemostasis and coagulation disorders in pregnancy. In: Bloom AL, Thomas DP, eds. Haemostasis and thrombosis. 2nd ed. Edinburgh, Scotland: Churchill Livingstone, 1987:570-84.
10. Woodhams BJ, Candotti G, Shaw R, Kernoff PB. Changes in coagulation and fibrinolysis during pregnancy: evidence of activation of coagulation preceding spontaneous abortion. Thromb Res 1989;55:99-107
11. Weiner CP, Kwaan H, Hauck WW, Duboe FJ, Paul M, Wallemark CB. Fibrin generation in normal pregnancy. Obstet Gynecol 1984;64:46-8.
12. Bremme K, Östlund E, Almqvist I, Heinonen K, Blombäck M. Enhanced thrombin generation and fibrinolytic activity in normal pregnancy and the puerperium. Obstet Gynecol 1992;80:132-7.
13. Gerbasi FR, Bottoms S, Farag A, Mammen E. Increased intravascular coagulation associated with pregnancy. Obstet Gynecol 1990;75:385-9.
14. Faught W, Garner P, Jones G, Ivey B. Changes in protein C and protein S levels in normal pregnancy. Am J Obstet Gynecol 1995;172:147-50.
15. Kruithof EK, Tran-Thang C, Gudinchet A, et al. Fibrinolysis in pregnancy: a study of plasminogen activator inhibitors. Blood 1987;69:460-6.
16. Hellgren M, Blombäck M. Studies on blood coagulation and fibrinolysis in pregnancy, during delivery and in the puerperium. I. Normal condition. Gynecol Obstet Invest 1981;12:141-54.
17. Ridker PM, Hennekens CH, Lindpaintner K, Stampfer MJ, Eisenberg PR, Miletich JP. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med 1995;332:912-7.
18. Cook G, Walker ID, McCall F, Conkie JA, Greer IA. Familial thrombophilia. and activated protein C resistance: thrombotic risk in pregnancy? Br J Haematol 1994;87:873-5.
19. Hiilesmaa V. Occurrence and anticoagulant treatment of thromboembolism in gravidas, parturients and gynecologic patients: a study of 678 cases treated in the Women's Clinic of the University of Helsinki in 1953-1957. Acta Obstet Gynecol Scand 1960;39:Suppl 2:5-12.
20. Jeffcoate TNA, Miller J, Roos RF, Tindall VR. Puerperal thromboembolism in relation to the inhibition of lactation by oestrogen therapy. BMJ 1968;3:19-25.
21. Bergqvist D, Hedner U. Pregnancy and venous thrombo-embolism. Acta Obstet Gynecol Scand 1983;62:449-53.
22. Ginsberg JS, Brill-Edwards P, Burrows RF, et al. Venous thrombosis during pregnancy: leg and trimester of presentation. Thromb Haemost 1992;67:519-20.
23. Bergqvist A, Bergqvist D, Hallböök T. Deep vein thrombosis during pregnancy: a prospective study. Acta Obstet Gynecol Scand 1983;62:443-8.
24. Hull RD, Raskob GE, Carter CJ. Serial impedance plethysmography in pregnant patients with clinically suspected deep-vein thrombosis: clinical validity of negative findings. Ann Intern Med 1990;112:663-7.
25. Weinmann EE, Salzman EW. Deep-vein thrombosis. N Engl J Med 1994;331:1630-41.
26. Hull RD, Hirsh J, Carter CJ, et al. Diagnostic efficacy of impedance plethysmography for clinically suspected deep-vein thrombosis: a randomized trial. Ann Intern Med 1985;102:21-8.
27. Huisman MV, Büller HR, ten Cate JW, Heijermans HS, van der Laan J, van Maanen DJ. Management of clinically suspected acute venous thrombosis in outpatients with serial impedance plethysmography in a community hospital setting. Arch Intern Med 1989;149:511-3.
28. Nicholas GG, Lorenz RP, Botti JJ, Chez RA. The frequent occurrence of false-positive results in phleborheography during pregnancy. Surg Gynecol Obstet 1985;161:133-5.
29. Didolkar SM, Koontz C, Schimberg PI. Phleborheography in pregnancy. Obstet Gynecol 1983;61:363-6.
30. Spritzer CE, Evans AC, Kay HH. Magnetic resonance imaging of deep venous thrombosis in pregnant women with lower extremity edema. Obstet Gynecol 1995;85:603-7.
31. Ginsberg JS, Hirsh J, Rainbow AJ, Coates G. Risks to the fetus of radiologic procedures used in the diagnosis of maternal venous thromboembolic disease. Thromb Haemost 1989;61:189-96.
32. Ang CK, Tan TH, Walters WA, Wood C. Postural influence on maternal capillary oxygen and carbon dioxide tension. BMJ 1969;4:201-3.
33. The PIOPED Investigators. Value of the ventilation/perfusion scan in acute pulmonary embolism: results of the Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED). JAMA 1990;263:2753-9.
34. Hull RD, Hirsh J, Carter CJ, et al. Pulmonary angiography, ventilation lung scanning, and venography for clinically suspected pulmonary embolism with abnormal perfusion lung scan. Ann Intern Med 1983;98: 891-9.
35. Ginsberg JS, Hirsh J. Use of antithrombotic agents during pregnancy. Chest 1995;108:Suppl:305S-311S.
36. Hirsh J. Heparin. N Engl J Med 1991;324:1565-74.
37. Cruickshank MK, Levine MN, Hirsh J, Roberts R, Siguenza M. A standard heparin nomogram for the management of heparin therapy. Arch Intern Med 1991;151:333-7.
38. Hull RD, Raskob GE, Rosenbloom D, et al. Optimal therapeutic level of heparin therapy in patients with venous thrombosis. Arch Intern Med 1992;152:1589-95.
39. Hall JG, Pauli RM, Wilson KM. Maternal and fetal sequelae of anticoagulation during pregnancy. Am J Med 1980;68:122-40.
40. Wong V, Cheng CH, Chan KC. Fetal and neonatal outcome of exposure to anticoagulants during pregnancy. Am J Med Genet 1993;45:17-21.
41. Hull R, Delmore T, Carter C, et al. Adjusted subcutaneous heparin versus warfarin sodium in the long-term treatment of venous thrombosis. N Engl J Med 1982;306:189-94.
42. Hyers TM, Hull RD, Weg JG. Antithrombotic therapy for venous thromboembolic disease. Chest 1995;108:Suppl:335S-351S.
43. Barss VA, Schwartz PA, Greene MF, Phillippe M, Saltzman D, Frigoletto FD. Use of the subcutaneous heparin pump during pregnancy. J Reprod Med 1985;30:899-901.
44. Anderson DR, Ginsberg JS, Brill-Edwards P, Demers C, Burrows RF, Hirsh J. The use of an indwelling Teflon catheter for subcutaneous heparin administration during pregnancy: a randomized crossover study. Arch Intern Med 1993;153:841-4.
45. Warkentin TE, Levine MN, Hirsh J, et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 1995;332:1330-5.
46. Monreal M, Lafoz E, Olive A, del Rio L, Vedia C. Comparison of subcutaneous unfractionated heparin with a low molecular weight heparin (Fragmin) in patients with venous thromboembolism and contraindications for coumarin. Thromb Haemost 1994;71:7-11.
47. Omri A, Delaloye JF, Andersen H, Bachmann F. Low molecular weight heparin Novo (LHN-I) does not cross the placenta during the second trimester of pregnancy. Thromb Haemost 1989;61:55-6.
48. Gillis A, Shushan A, Eldor A. Use of low molecular weight heparin for prophylaxis and treatment of thromboembolism in pregnancy. Int J Gynecol Obstet 1992;39:297-301.
49. Melissari E, Parker CJ, Wilson NV, et al. Use of low molecular weight heparin in pregnancy. Thromb Haemost 1992;68.652-6.
50. Greentield LJ, Cho KJ, Proctor MC, Sobel M, Shah S, Wingo J. Late results of suprarenal Greenfield vena cava filter placement. Arch Surg 1992; 127:969-73.
51. Narayan H, Cullimore J, Krarup K, Thurston H, Macvicar J, Bolia A. Experience with the Cardial inferior vena cava filter as prophylaxis against pulmonary embolism in pregnant women with extensive deep venous thrombosis. Br J Obstet Gynaecol 1992;99:637-40. [Erratum, Br J Obstet Gynaecol 1992;99:726,]
52. Fagher B, Ahlgren M, Astedt B. Acute massive pulmonary embolism treated with streptokinase during labor and the early puerperium. Acta Obstet Gynecol Scand 1990;69:659-61
53. Dahlman TC, Hellgren MS, Blombäck M. Thrombosis prophylaxis in pregnancy with use of subcutaneous heparin adjusted by monitoring heparin concentration in plasma. Am J Obstet Gynecol 1989;161: 420-5.
54. Horlocker TT. Central neural blockage for patients receiving anticoagulants. In: Barash PG, Cullen BF, Stoelling RK, eds. Clinical anesthesia updates. Vol. 5. Philadelphia: J.B. Lippincott, 1994:1-9.
55. Anderson DR, Ginsberg JS, Burrows R, Brill-Edwards P. Subcutaneous heparin therapy during pregnancy: a need for concern at the time of delivery. Thromb Haemost 1991;65:248-50.
56. Ginsberg JS, Kowalchuk G, Hirsh J, Brill-Edwards P, Burrows R. Heparin therapy during pregnancy: risks to the fetus and mother. Arch Intern Med 1989;149:2233-6.
57. Wise PH, Hall AJ. Heparin-induced osteopenia in pregnancy. BMJ 1980;281:110-1.
58. Dahlman T, Lindvall N, Hellgren M. Osteopenia in pregnancy during long-term heparin treatment: a radiological study post partum. Br J Obstet Gynaecol 1990;97:221-8.
59. Ginsberg JS, Kowalchuk G, Hirsh J, et al. Heparin effect on bone density. Thromb Haemost 1990;64:286-9.
60. Tengborn L, Bergqvist D, Mätzsch T, Bergqvist A, Hedner U. Recurrent thromboembolism in pregnancy and puerperium: is there a need for thromboprophylaxis? Am J Obstet Gynecol 1989;160:90-4.
61. Badaracco MA, Vessey MP. Recurrence of venous thromboembolic disease and use of oral contraceptives. BMJ 1974;1:215-7.
62. Bremme K, Lind H, Blombäck M. The effect of prophylactic heparin treatment on enhanced thrombin generation in pregnancy. Obstet Gynecol 1993;81:78-83.
63. Dahlman TC. Osteoporotic fractures and the recurrence of thromboembolism during pregnancy and the puerperium in 184 women undergo-ing thromboprophylaxis with heparin. Am J Obstet Gynecol 1993;168: 1265-70.
64. Hellgren M, Tengborn L, Abildgaard U. Pregnancy in women with congenital antithrombin III deficiency: experience of treatment with heparin and antithrombin. Gynecol Obstet Invest 1982;14:127-41.
65. Brandt P. Observations during the treatment of antithrombin-III deficient women with heparin and antithrombin concentrate during pregnancy, parturition, and abortion. Thromb Res 1981;22:15-24.
66. Brenner B, Shapira A, Bahari C, Haimovich L, Seligsohn U. Hereditary protein C deficiency during pregnancy. Am J Obstet Gynecol 1987;157: 1160-1.
67. Trauscht-Van Horn JJ, Capeless EL, Easterling TR, Bovill EG. Pregnancy loss and thrombosis with protein C deficiency. Am J Obstet Gynecol 1992;167:968-72.
68. Finazzi G, Barbui T. Different incidence of venous thrombosis in patients with inherited deficiencies of antithrombin III, protein C and protein S. Thromb Haemost 1994;71:15-8.
69. Branch DW, Scott JR, Kochenour NK, Hershgold E. Obstetric complications associated with the lupus anticoagulant. N Engl J Med 1985;313: 1322-6.
70. Khamashta MA, Cuadrado MJ, Mujic F, Taub NA, Hunt BJ, Hughes GRV. The management of thrombosis in the antiphospholipid-antibody syndrome. N Engl J Med 1995;332:993-7.