Hydrolytic cleavage of pyroglutamyl-peptide bond. II. effects of amino acid residue neighboring the pglu moiety

Biological and Pharmaceutical Bulletin

Volumn 19, Issue 5, 1996, Pages 768-770

  Saito, Susumu ^a   Ohki, Kazuhiro ^a   Sakura, Naoki ^a   Hashimoto, Tadashi ^a  

^a HOKURIKU UNIVERSITY   (Japan)

Author keywords

Cleavage reaction; Hydrochloric acid; Hydrolysis; Pyroglutamyl peptide; Pyroglutamyl peptide bond; Trifluoromethanesulfonic acid

Indexed keywords

AMINO ACID DERIVATIVE; FLUOROFORM; HYDROCHLORIC ACID; PROTEIN HYDROLYSATE; PYROGLUTAMIC ACID; SULFONIC ACID DERIVATIVE;

ARTICLE; HALF LIFE TIME; HYDROLYSIS; PEPTIDE SYNTHESIS; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION;

EID: 0029977825     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.19.768     Document Type: Article

References (4)

1. Part I: Hashimoto T., Ohki K., Sakura N., Chem. Pharm. Bull., 43, 2068-2074 (1995).
2. Amino acids and their derivatives except for those of glycine are of L-configuration unless otherwise indicated. The abbreviations for amino acids and peptides are in accordance with the rules of the IUPAC-IUB Commission on Biochemical Nomenclature in Eur. J. Biochem., 138, 9-37 (1984). Other abbrevaiations used are: MeCN, acetonitrile; TFA, trifluoroacetic acid; RP-HPLC, reversed-phase high-performance liquid chromatography.
3. Part of this work was reported as a preliminary communication: Saito S., Ohki K., Sakura N., Hashimoto T., "Peptides Chemistry 1995," ed. by Nishi N., Protein Research Foundation, Osaka, 1996, pp. 85-88.
4. Blombäck B., "Methods in Enzymology," Vol. 11, ed. by Hirs C.H.W., Academic Press, New York, 1967, pp. 398-411.