Early biosynthetic changes in the diabetic-like retinopathy of galactose-fed rats

Diabetologia

Volumn 39, Issue 6, 1996, Pages 735-738

  Roy, S ^a   Lorenzi, M ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

Basement membranes; Collagen IV; Diabetic retinopathy; Fibronectin; Gene expression

Indexed keywords

COLLAGEN TYPE 4; FIBRONECTIN; GALACTOSE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GALACTOSEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RETINOPATHY;

EID: 0029977817     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00418547     Document Type: Article

References (10)

1. Engerman RL, Kern TS (1995) Retinopathy in animal models of diabetes. Diabetes Metab Rev 11: 109-120
2. Roy S, Maiello M, Lorenzi M (1994) Increased expression of basement membrane collagen in human diabetic retinopathy. J Clin Invest 93: 438-442
3. Robison WG, Kador PF, Kinoshita JH (1983) Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor. Science 221: 1177-1179
4. Das A, Frank RN, Zhang NL, Samadani E (1990) Increases in collagen type IV and laminin in galactose-induced retinal capillary basement membrane thickening - prevention by an aldose reductase inhibitor. Exp Eye Res 50: 269-280
5. Essner E, Lin WL (1988) Immunocytochemical localization of laminin, type IV collagen and fibronectin in rat retinal vessels. Exp Eye Res 47: 317-327
6. Roy S, Cagliero E, Lorenzi M (1996) Fibronectin overexpression in retinal microvessels of diabetic patients. Invest Ophthalmol Vis Sci 37: 258-266
7. Cagliero E, Roth T, Roy S, Lorenzi M (1991) Characteristics and mechanisms of high glucose-induced overexpression of basement membrane components in cultured human endothelial cells. Diabetes 40: 102-110
8. Roy S, Sala R, Cagliero E, Lorenzi M (1990) Overexpression of fibronectin induced by diabetes or high glucose: phenomenon with a memory. Proc Natl Acad Sci USA 87: 404-408
9. Sarthy V (1993) Collagen IV mRNA expression during development of the mouse retina: an in situ hybridization study. Invest Ophthalmol Vis Sci 34: 145-152
10. Mandarino LJ, Sundarraj N, Finlayson J, Hassell JR (1993) Regulation of fibronectin and laminin synthesis by retinal capillary endothelial cells and pericytes in vitro. Exp Eye Res 57: 609-621