A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains

EMBO Journal

Volumn 15, Issue 12, 1996, Pages 3105-3116

  Goppelt, Andreas ^a   Stelzer, Gertraud ^a   Lottspeich, Friedrich ^b   Meisterernst, Michael ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Basal transcription; Co factor 2; DNA binding proteins; Negative; Transcriptional regulation; Transcriptional repression

Indexed keywords

DNA BINDING PROTEIN; HISTONE; TATA BINDING PROTEIN;

ARTICLE; CLONE; COMPLEX FORMATION; GENE REPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; REPRESSOR GENE; TRANSCRIPTION REGULATION;

EID: 0029977801     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00673.x     Document Type: Article

References (58)

1. Arents,G. and Moudrianakis,E.N. (1995) The histone fold: a ubiquitous architectural motif utilized in DNA compaction and protein dimerization. Proc. Natl Acad. Sci. USA, 92, 11170-11174.
2. Arents,G., Burlingame,R.W., Wang,B.-C., Love,W.E. and Moudrianakis,E.N. (1991) The nucleosomal core histone octamer at 3.1 Å resolution: a tripartite protein assembly and a left-handed superhelix. Proc. Natl Acad. Sci. USA, 88, 10148-10152.
3. Auble,D.T., Hansen,K.E., Mueller,C.G., Lane,W.S., Thorner,J. and Hahn,S. (1994) Mot1, a global repressor of RNA polymerase II transcription, inhibits TBP binding to DNA by an ATP-dependent mechanism. Genes Dev., 8, 1920-1934.
4. Austin,R.L. and Biggin,M.D. (1995) A domain of the even-skipped protein represses transcription by preventing TFIID binding to a promoter: repression by cooperative blocking. Mol. Cell. Biol., 15, 4683-4693.
5. Baeuerle,P. and Baltimore,D. (1988) A specific inhibitor of the NF-κB transcription factor. Science, 242, 540-545.
6. Bagby,S., Kim,S., Maldonado,E., Tong,K.I., Reinberg,D. and Ikura,M. (1995) Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein. Cell, 82, 857-867.
7. Baxevanis,A.D., Arents,G., Moundrianakis,E.N. and Landsman,D. (1995) A variety of DNA-binding and multimeric proteins contain the histone fold motif. Nucleic Acids Res., 23, 2685-2691.
8. Benezra,R., Davis,R.L., Lockshon,D., Turner,D.L. and Weintraub,H. (1990) The protein Id, a negative regulator of helix-loop-helix DNA binding protein. Cell, 61, 49-59.
9. Buratowski,S., Hahn,S., Guarente,L. and Sharp,P.A. (1989) Five intermediate complexes in transcription by RNA polymerase II. Cell, 56, 549-561.
10. Chen,J.D. and Evans,R.M. (1995) A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature, 377, 454-457.
11. Conaway,R.C. and Conaway,J.W. (1993) General initiation factors for RNA polymerase II. Annu. Rev. Biochem., 62, 161-190.
12. DeJong,J. and Roeder,R.G. (1993) A single cDNA, hTFIIA/α, encodes both the p35 and p19 subunits of human TFIIA. Genes Dev., 7, 2220-2234.
13. Dynlacht,B.D., Hoey,T. and Tjian,R. (1991) Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation. Cell, 66, 563-576.
14. Ge,H. and Roeder,R.G. (1994) Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Cell, 78, 513-523.
15. Han,K. and Manley,J.L. (1993) Transcriptional repression by the Drosophila even-skipped protein, definition of a minimal repression domain. Genes Dev., 7, 491-503.
16. Halle,J.-P., Stelzer,G., Goppelt,A. and Meisterernst,M. (1995) Activation of transcription by recombinant upstream stimulatory factor 1 is mediated by a novel positive cofactor. J. Biol. Chem., 270, 21307-21311.
17. Horikoshi,M., Carey,M.F., Kakidani,H. and Roeder,R.G. (1988) Mechanism of action of a yeast activator: direct effect of GAL4 derivatives on mammalian TFIID-promoter interactions. Cell, 54, 665-669.
18. Horikoshi,M., Bertuccioli,C., Takada,R., Wang,J., Yamamoto,T. and Roeder,R.G. (1992) Transcription factor TFIID induces DNA bending upon binding to the TATA element. Proc. Natl Acad. Sci. USA, 89, 1060-1064.
19. Hörlein,A.J., Näär,A.M., Heinzel,T., Torchia,J., Gloss,B., Kurokawa,R., Ryan,A., Kamei,Y., Söderström,M., Glass,C.K. and Rosenfeld,M.G. (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature, 377, 397-404.
20. Inostroza,J.A., Mermelstein,F.H., Ilho,H., Lane,W.S. and Reinberg,D. (1992) Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. Cell, 70, 477-489.
21. Kaiser,K., Stelzer,G. and Meisterernst,M. (1995) The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation. EMBO J., 14, 3520-3527.
22. Kato,H., Horikoshi,M. and Roeder,R.G. (1991) Repression of HIV-1 transcription by a cellular protein. Science, 251, 1476-1479.
23. Kim,T.K., Zhao,Y., Bernstein,R. and Roeder,R.G. (1995) TATA-binding protein residues implicated in a functional interplay between negative cofactor NC2 (Dr1) and general factors TFIIA and TFIIB. J. Biol. Chem., 270, 10976-10981.
24. Kim,Y.-J., Björklund,S., Li,Y., Sayre,M.H. and Kornberg,R. (1994) A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell, 77, 599-608.
25. Kokubo,T., Gong,D.W., Wooton,J.C., Horikoshi,M., Roeder,R.G. and Nakatani,Y. (1994) Molecular cloning of Drosophila TFIID subunits. Nature, 367, 484-487.
26. Koleske,A.J. and Young,R.A. (1994) An RNA polymerase II holoenzyme responsive to activators. Nature, 368, 466-469.
27. Kraus,V.B., Inostroza,J.A., Yeung,K., Reinberg,D. and Nevins,J.R. (1994) Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A. Proc. Natl Acad. Sci. USA, 91, 6279-6282.
28. Kretzschmar,M., Stelzer,G., Roeder,R.G. and Meisterernst,M. (1994a) RNA polymerase II cofactor PC2 facilitates activation of transcription by Gal-AH in vitro. Mol. Cell. Biol., 14, 3927-3937.
29. Kretzschmar,M., Kaiser,K., Lottspeich,F. and Meisterernst,M. (1994b) A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators. Cell, 78, 525-534.
30. Kurokawa,R., Söderström,M., Hörlein,A., Halachmi,S., Brown,M., Rosenfeld,M.G. and Glass,C.K. (1995) Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature, 377, 451-454.
31. Lee,S. and Hahn,S. (1995) Model for binding of transcription factor TFIIB to the TBP-DNA complex. Nature, 376, 609-612.
32. Lewin,B. (1994) Chromatin and gene expression; constant questions. but changing answers. Cell, 79, 397-406.
33. Licht,J.D., Hanna-Rose,W., Teddy,J.C., English,M.A., Ro,M., Grossel,M., Shaknovich,R. and Hansen,U.M. (1994) Mapping and mutagenesis of the amino-terminal transcriptional repression domain of the Drosophila Krüppel protein. Mol. Cell. Biol., 14, 4057-4066.
34. Majumder,S., Miranda,M. and DePamphilis,M.L. (1993) Analysis of gene expression in mouse preimplantation embryos demonstrates that the primary role of enhancers is to relieve repression of promoters. EMBO J., 12, 1131-1140.
35. Martinez-Balbas,M.A., Dey,A., Rabindran,S.K., Ozato,K. and Wu,C. (1995) Displacement of sequence-specific transcription factors from mitotic chromatin. Cell, 83, 29-38.
36. Meisterernst,M. and Roeder,R.G. (1991) Family of proteins that interact with TFIID and regulate promoter activity. Cell, 67, 557-567.
37. Meisterernst,M., Roy,A.L., Lieu,H.M. and Roeder,R.G. (1991) Activation of class II gene transcription by regulatory factors is potentiated by a novel activity. Cell, 66, 981-993.
38. Mengus,G., May,M., Jacq,X., Staub,A., Tora,L., Chambon,P. and Davidson,I. (1995) Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. EMBO J., 14, 1520-1531.
39. Nikolov,D.B., Chen,H., Halay,E.D., Usheva,A.A., Hisatake,K., Lee,D.K., Roeder,R.G. and Burley,S.K. (1995) Crystal structure of a TFIIB-TBP-TATA-element ternary complex. Nature, 377, 119-128.
40. Ossipow,V., Tassan,J.-P., Nigg,E.A. and Schibler,U. (1995) A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation. Cell, 83, 137-146.
41. Ozer,J., Moore,P.A., Bolden,A.H., Lee,A., Rosen,C.A. and Lieberman, P.M. (1994) Molecular cloning of the small (γ) subunit of human TFIIA reveals functions critical for activated transcription. Genes Dev., 8, 2324-2335.
42. Pruss,D., Hayes,J.J. and Wolffe,A.P. (1995) Nucleosomal anatomy - where are the histones? BioEssays, 17, 161-170.
43. Roeder,R.G. (1991) The complexity of eukaryotic transcription initiation: regulation of pre-initiation complex assembly. Trends Biochem. Sci., 16, 402-408.
44. Sauer,F., Fondell,J.D., Ohkuma,Y., Roeder,R.G. and Jäckle,H. (1995) Control of transcription by Krüppel through interactions with TFIIB and TFIIEβ. Nature, 375, 162-164.
45. Shi,Y., Seto,E., Chang,L.-S. and Shenk,T. (1991) Transcriptional repression by YYI, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein. Cell, 67, 377-388.
46. Sinha,S., Maity,S.N., Lu,J. and de Crombrugghe,B. (1995) Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Proc. Natl Acad. Sci. USA, 92, 1624-1628.
47. Starr,D.B., Hoopes,B.C. and Hawley,D.K. (1995) DNA bending is an important component of site-specific recognition by the TATA binding protein. J. Mol. Biol., 250, 434-446.
48. Stelzer,G., Goppelt,A., Lottspeich,F. and Meisterernst,M. (1994) Repression of basal transcription by HMG2 is counteracted by TFIIH-associated factors in an ATP-dependent process. Mol. Cell. Biol., 14, 4712-4721.
49. Sun,X., Ma,D., Sheldon,M., Yeung,K. and Reinberg,D. (1994) Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription. Genes Dev., 8, 2336-2348.
50. Tzamarias,D. and Struhl,K. (1994) Functional dissection of the yeast Cyc8-Tup1 transcriptional co-repressor complex. Nature, 369, 758-761.
51. Verrijzer,C.P., Chen,J.-L., Yokomori,K. and Tjian,R. (1995) Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II. Cell, 81, 1115-1125.
52. White,R.J., Khoo,B.C., Inostroza,J.A. Reinberg,D. and Jackson,S.P. (1994) Differential regulation of RNA polymerases I, II, and III by the TBP-binding repressor Dr1. Science, 266, 448-450.
53. Wolffe,A.P. (1994) Transcription: in tune with the histones. Cell, 77, 13-16.
54. Workman,J.L., Roeder,R.G. and Kingston,R.E. (1990) An upstream transcription factor USF (MLTF), facilitates the formation of preinitiation complexes during in vitro chromatin assembly. EMBO J., 9, 1299-1308.
55. Xing,Y., Fikes,J.D. and Guarente,L. (1993) Mutations in yeast HAP2/HAP3 define a hybrid CCAAT box binding domain. EMBO J., 12, 4647-4655.
56. Yeung,K.C., Inostroza,J.A., Mermelstein,F.H., Kannabiran,C. and Reinberg,D. (1994) Structure-function analysis of the TBP-binding protein Dr1 reveals a mechanism for repression of class II gene transcription. Genes Dev., 8, 2097-2109.
57. Yokomori,K., Zeidler,M.P., Chen,J.-J., Verrijzer,C.P., Mlodzik,M. and Tjian,R. (1994) Drosophila TFIIA directs cooperative DNA binding with TBP and mediates transcriptional activation. Genes Dev., 8, 2313-2323.
58. Zawel,L. and Reinberg,D. (1995) Common themes in assembly and function of eukaryotic transcription complexes. Annu. Rev. Biochem., 64, 533-561.