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Crystal structure of the soluble human 55kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation
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Nagata S, Goldstein P: The Fas death factor. Science 1995, 267:1449-1456.
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Nagata, S.1
Goldstein, P.2
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0029025441
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Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
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Fisher GH, Rosenberg FJ, Straus SE, Dale JK, Middleton LA, Lin AY, Strober W, Lenardo MJ, Puck JM: Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 1995, 81:935-946.
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Fisher, G.H.1
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0029006893
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Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity
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Rieux-Laucat F, Le Deist F, Hivroz C, Roberts IAG, Debatin KM, Fischer A, de Villartay JP: Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 1995, 268:1347-1349.
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Rieux-Laucat, F.1
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Fischer, A.6
De Villartay, J.P.7
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How B and T cells talk to each other
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Clark EA, Ledbettter JA: How B and T cells talk to each other. Nature 1994, 367:425-428.
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Clark, E.A.1
Ledbettter, J.A.2
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0028124428
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A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
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Rothe M, Wong SC, Henzel WJ, Goeddel DV: A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 1994, 78:681-692. Reports the initial characterization of TRAF1 and TRAF2 and describes the binding specificities of these two proteins for TNFR2. The authors show that TNFR2 mutants that fail to signal also fail to bind TRAF2 and that TRAF1 interacts with TNFR2 only in the presence of TRAF2.
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Rothe, M.1
Wong, S.C.2
Henzel, W.J.3
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0027943499
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A novel RING finger protein interacts with the cytoplasmic domain of CD40
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Hu HM, O'Rourke K, Boguski MS, Dixit VM: A novel RING finger protein interacts with the cytoplasmic domain of CD40. J Biol Chem 1994, 269:30069-30072. First report of the cloning of an intracellular CD40-specific binding protein, CD40bp, identical to CRAF1.
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Hu, H.M.1
O'Rourke, K.2
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Dixit, V.M.4
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Involvement of CRAF1, a relative of TRAF, in CD40 signaling
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Cheng G, Cleary AM, Ye Z, Hong DI, Lederman S, Baltimore D: Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science 1995, 267:1494-1498. Reports the cloning of CRAF1 by yeast two hybrid screening using CD40 and demonstrates specificity of binding relative to Fas or TNFR2.
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Science
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Cheng, G.1
Cleary, A.M.2
Ye, Z.3
Hong, D.I.4
Lederman, S.5
Baltimore, D.6
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15
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0028878977
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The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family
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Mosialos G, Birkenbach M, Yalamanchili R, Van Arsdale T, Ware C, Kieff E: The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 1995, 80:389-399. Reports the cloning of LAP1, or CRAF1, by yeast two hybird screening using Epstein-Barr virus LMP1. The authors identify a weak association between RAF1 and both TNFR2 and Fas.
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Mosialos, G.1
Birkenbach, M.2
Yalamanchili, R.3
Van Arsdale, T.4
Ware, C.5
Kieff, E.6
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16
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0028809176
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A novel member of the TRAF family of putative signal transducing proteins binds to the cytoplasmic domain of CD40
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Sato T, Irie S, Reed JC: A novel member of the TRAF family of putative signal transducing proteins binds to the cytoplasmic domain of CD40. FEBS Lett 1995, 358:113-118. Reports the cloning of CAP-1, or CRAF1, by yeast two hybrid screening using CD40. Demonstrates capacity for CRAF1 homodimerization.
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Sato, T.1
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Reed, J.C.3
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0029026548
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FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
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Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM: FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995, 81:505-512. Reports the cloning of FADD by yeast two hybird screening using Fas. Demonstrates that overexpression of FADD and even some FADD mutants unable to bind Fas lead to apoptosis.
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Chinnaiyan, A.M.1
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Tewari, M.3
Dixit, V.M.4
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0029054725
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RIP: A novel protein containing a death domain that interacts with Fas/Apo-1 (CD95) in yeast and causes cell death
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Stanger BZ, Leder P, Lee T, Kim E, Seed B: RIP: a novel protein containing a death domain that interacts with Fas/Apo-1 (CD95) in yeast and causes cell death. Cell 1995, 81:513-523. Reports the cloning of RIP by yeast two hybrid screening using Fas. Demonstrates binding specificity and apoptotic induction of RIP.
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Stanger, B.Z.1
Leder, P.2
Lee, T.3
Kim, E.4
Seed, B.5
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19
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0029007855
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The TNF receptor 1-associated protein TRADD signals cell death and NF-κ B activation
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Hsu H, Xiong J, Goeddel DV: The TNF receptor 1-associated protein TRADD signals cell death and NF-κ B activation. Cell 1995, 81:495-504. Reports the cloning of TRADD by yeast two hybrid screening using TNFR1. Distinguishes the ability of TRADD to induce apoptosis from the ability to activate NFκB.
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Hsu, H.1
Xiong, J.2
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0029066512
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FAP-1: A protein tyrosine phosphatase that associates with Fas
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Sato T, Irie S, Kitada S, Reed JC: FAP-1: a protein tyrosine phosphatase that associates with Fas. Science 1995, 268:411-415.
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Science
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Sato, T.1
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Reed, J.C.4
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0028941699
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Defective expression of hematopoletic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis
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Su X, Zhou T, Wang Z, Yang P, Jope RS, Mountz JD: Defective expression of hematopoletic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis. Immunity 1995, 2:353-362. Describes the essential role of hematopoietic cell protein tyrosine phosphatase in Fas signaling.
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Immunity
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Su, X.1
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Wang, Z.3
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Mountz, J.D.6
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22
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0028964917
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Fas-induced apoptosis is mediated via a ceramide-initiated Ras signaling pathway
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Gulbins E, Bissonnette R, Mahboubi A, Martin S, Nishioka W, Brunner T, Baier G, Baier-Bitterlich G, Byrd C, Lang F, Kolesnick R, Altman A, Green D: Fas-induced apoptosis is mediated via a ceramide-initiated Ras signaling pathway. Immunity 1995, 2:341-351. Describes the involvement of ceramide production and Ras activation in Fas signaling.
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Immunity
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Gulbins, E.1
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The B7 and CD28 receptor families
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June CH, Bluestone JA, Nadler LM, Thompson CB: The B7 and CD28 receptor families. Immunol Today 1994, 15:321-331.
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Immunol Today
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June, C.H.1
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Thompson, C.B.4
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24
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0029163387
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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL
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Boise LH, Minn AJ, Noel PJ, June CH, Accavitti MA, Lindsten T, Thompson CB: CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL. Immunity 1995, 3:87-98. The authors demonstrate that CD28 signaling has an antiapoptotic effect specifically on T cells activated through the T-cell receptor and argue that this effect is explained by induction of Bc-xL gene expression.
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Immunity
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Boise, L.H.1
Minn, A.J.2
Noel, P.J.3
June, C.H.4
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Lindsten, T.6
Thompson, C.B.7
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25
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0028870051
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CTLA4 mediates antigen-specific apoptosis of human T cells
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Gnbben JG, Freeman GJ, Boussiotis VA, Renner P, Jellis CL, Greenfield E, Barber M, Restivo VA, Ke X, Gray GS, Nadler LM: CTLA4 mediates antigen-specific apoptosis of human T cells. Proc Natl Acad Sci U S A 1995, 92:811-815. The authors demonstrate that CTLA4 signaling is able to promote apoptosis in activated T cells. As with CD28 signaling, the CTLA4 pathway is dependent on T-cell receptor occupancy, thus promoting clonal specificity of the response. The authors demonstrate that the apoptotic signal is not induced by either of the two known ligands for CTLA4 and hypothesize the existence of additional ligands.
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Proc Natl Acad Sci U S A
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Jellis, C.L.5
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Barber, M.7
Restivo, V.A.8
Ke, X.9
Gray, G.S.10
Nadler, L.M.11
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26
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0028485743
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The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice
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Singer GG, Abbas AK: The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1994, 1:365-371.
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Immunity
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Singer, G.G.1
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27
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0028920079
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Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells
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Rothstein TL, Wang JKM, Panka DJ, Foote LC, Wang Z, Stanger B, Cui H, Ju S, Marshak-Rothstein A: Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature 1995, 374:163-165.
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Nature
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Rothstein, T.L.1
Wang, J.K.M.2
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Foote, L.C.4
Wang, Z.5
Stanger, B.6
Cui, H.7
Ju, S.8
Marshak-Rothstein, A.9
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28
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0029076561
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CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells
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Rathmell JC, Cooke MP, Ho WY, Grein J, Townsend SE, Davis MM, Goodnow CC: CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. Nature 1995, 376:181-183. Identifies the role of Fas-mediated apoptosis in clonal deletion of anergic B cells in vivo.
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Nature
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Rathmell, J.C.1
Cooke, M.P.2
Ho, W.Y.3
Grein, J.4
Townsend, S.E.5
Davis, M.M.6
Goodnow, C.C.7
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