An investigation of the effects of heparin, low molecular weight heparin, protamine, and fentanyl on the balance of pro- and anti-inflammatory cytokines in in-vitro monocyte cultures

Anaesthesia

Volumn 51, Issue 7, 1996, Pages 634-640

  McBride, W T ^a,c   Armstrong, M A ^a   McMurray, T J ^b  

^a Department of Anaesthetics ^*

^b ROYAL VICTORIA HOSPITAL   (United Kingdom)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Analgesics; fentanyl; Blood; heparin, low molecular weight heparin, protamine; Polypeptides; cytokines

Indexed keywords

CYTOKINE; ENOXAPARIN; FENTANYL; FENTANYL CITRATE; HEPARIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; LOW MOLECULAR WEIGHT HEPARIN; PROTAMINE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; HEART SURGERY; HUMAN; HUMAN CELL; MAJOR SURGERY; MONOCYTE;

ANALGESICS, OPIOID; ANTICOAGULANTS; CARDIAC SURGICAL PROCEDURES; CELL CULTURE TECHNIQUES; CYTOKINES; FENTANYL; HEPARIN; HEPARIN ANTAGONISTS; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; INTERLEUKIN-1; MONOCYTES; PROTAMINES; RECEPTORS, INTERLEUKIN-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029977706     PISSN: 00032409     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2044.1996.tb07844.x     Document Type: Article

References (25)

1. KNUDSEN F, ANDERSEN LW. Immunological aspects of cardiopulmonary bypass. Journal of Candiothoracic Anaesthesia 1990; 4: 245-58.
2. GU YJ, VAN OEVEREN W, BOONSTRA PW, DE HAAN J, WILDEVUUR CRH. Leucocyte activation with increased expression of CR3 receptors during cardiopulmonary bypass. Annals of Thoracic Surgery 1992; 53: 839-43.
3. FINN A, REBUCK N, MOAT N. Neutrophil activation during cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery 1992; 104: 1746-8.
4. LAHAT N, ZLOTNICK AY, SHTILLER R, BAR I, MERIN G. Serum levels of IL-1, IL-6 and TNF in patients undergoing coronary artery bypass grafts or cholecystectomy. Clinical and Experimental Immunology 1992; 89: 255-60.
5. JANSEN NJG, VAN OEVEREN W, GU YJ, VAN VLIET MJ, EIJSMAN L, WILDEVUUR CRH. Endotoxin release and tumor necrosis factor formation during cardiopulmonary bypass. Annals of Thoracic Surgery 1992; 54: 744-7.
6. MCBRIDE WT, ARMSTRONG MA, CROCKARD AD, MCMURRAY TJ, REA JM. Cytokine balance and immunosuppressive changes at cardiac surgery: contrasting response between patients and isolated CPB circuits. British Journal of Anaesthesia 1995; 75: 724-33.
7. MCBRIDE WT, ARMSTRONG MA, CROCKARD AD, MCMURRAY TJ. Effect of fentanyl on the immune response using an isolated cardiopulmonary bypass system. British Journal of Anaesthesia 1995; 75: P237-8.
8. CARR DJJ, DECOSTA BR, KIM CH, JACOBSON AE, GUARCELLO V, RICE KC, BLALOCK JE. Opioid receptors on cells of the immune system: evidence for delta and kappa classes. Journal of Endocrinology 1989; 122: 161-8.
9. LANTZ M, THYSELL H, NILSSON E, OLSSON I. On the binding of tumor necrosis factor (TNF) to heparin and the release in-vivo of the TNF-binding protein I by heparin. Journal of Clinical Investigation 1991; 88: 2026-31.
10. JOHN LC, REES GM, KOVACS IB. Different anticoagulants and platelet reactivity in cardiac surgical patients. Annals of Thoracic Surgery 1993; 56: 899-902.
11. KOZA MJ, MESSMORE HL, WALLOCK ME, WALENGA JM, PIFARRE R. Evaluation of a low molecular weight heparin as an anti-coagulant in a model of cardiopulmonary bypass surgery. Thrombosis Research 1993; 70: 67-76.
12. ARMSTRONG MA, CROCKARD AD, HAWKINS SA, GAMBLE L-A, SHAH S, BELL AL. Class II major histocompatibility complex antigen expression on unstimulated and gamma-interferon stimulated monocytes from patients with multiple sclerosis, rheumatoid arthritis and normal controls. Autoimmunity 1991; 9: 261-8.
13. BOYUM A. A one stage procedure for isolation of granulocytes and lymphocytes from human blood. Scandinavian Journal of Clinical Laboratory Investigation 1968; (Suppl. 97): 51-76.
14. ENDRES S, FULLE HJ, SINHA B, STOLL D, DINARELLO CA, GERZER R, WEBER PC. Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1 beta by human mononuclear cells. Immunology 1991; 72: 56-60.
15. HARTMAN DA, OCHALSKI SJ, CARLSON RP. The effects of anti-inflammatory and antiallergic drugs on the release of IL-1 beta and TNF-alpha in the human whole blood assay. Agents and Actions 1993; 39: C70-2.
16. MOLNAR-KIMBER K, YONNO L, HEASLIP R, WEICHMAN B. Modulation of TNF alpha and IL-1 beta from endotoxin-stimulated monocytes by selective PDE isozyme inhibitors. Agents and Actions 1993; 39: 77-9.
17. KAVELAARS A, BALLIEUX RE, HEIJNEN CJ. Differential effects of beta-endorphin on cAMP levels in human peripheral blood mononuclear cells. Brain, Behaviour and Immunity 1990; 4: 171-9.
18. ALEXANDER HR, SHEPPARD BC, JENSEN JC, LANGSTEIN HN, BURESH CM, VENZON D, WALKER EC, FRAKER DL, STOVROFF MC, NORTON JA. Treatment with recombinant human tumor necrosis factor-alpha protects rats against the lethality, hypotension and hypothermia of gram-negative sepsis. Journal of Clinical Investigation 1991; 88: 34-9.
19. KAPLAN E, DINARELLO CA, WAKABAYSHI G, BURKE JF, GELFAND JA. Interleukin-1 pretreatment protects against endotoxin-induced hypotension in rabbits: association with decreased tumor necrosis factor levels. Journal of Infectious Diseases 1993; 167: 244-7.
20. WANIDWORANUN C, STROBER W. Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis. Journal of Immunology 1993; 151: 6853-61.
21. [21 ] TILG H, MIER JW, VOGEL W, AULITZKY WE, WIEDERMANN CJ, VANNIER E, HUBER C, DINARELLO CA. Induction of circulating IL-1 receptor antagonist by interferon treatment. Journal of Immunology 1993; 150: 4687-92.
22. CASSATELLA MA, MEDA L, GASPERINI S, CALZETTI F, BONORA S. Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide stimulated polymorphonuclear leucocytes by delaying mRNA degradation. Journal of Experimental Medicine 1994; 179: 1695-9.
23. DI PADOVA F, POZZI C, TONDRE MJ, TRITAPEPE R. Selective and early increase if IL-1 inhibitors, IL-6 and cortisol after elective surgery. Clinical and Experimental Immunology 1991; 85: 137-42.
24. O'NUALLAIN EM, PURI P, REEN DJ. Early induction of IL-1 receptor antagonist (IL-1ra) in infants and children undergoing surgery. Clinical and experimental Immunology 1993; 93: 218-22.
25. ANAND KJS, HICKEY PR. Halothane-morphine compared with high dose sufentanil for anaesthesia and postoperative analgesia in neonatal cardiac surgery. New England Journal of Medicine 1992; 326: 1-9.