Aspects of the neoplasms observed in patients with constitutional autosomal trisomy

Cancer Genetics and Cytogenetics

Volumn 87, Issue 1, 1996, Pages 63-70

  Satge, Daniel ^a   Van Den Berghe, Herman ^b  

^a Service d'Anatomie Pathologique   (France)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CARCINOGENESIS; CHILDHOOD CANCER; EMBRYONAL CARCINOMA; GENETIC ANALYSIS; GERM CELL TUMOR; HUMAN; LEUKEMIA; LYMPHOMA; PARTIAL TRISOMY 9; PRIORITY JOURNAL; TRISOMY 13; TRISOMY 8;

EID: 0029977563     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-4608(95)00249-9     Document Type: Article

References (164)

1. Hecht F (1987): Risks of hematologic malignancy with constitutional chromosome abnormalities. Cancer Genet Cytogenet 24:375-377.
2. Isaacs, H Jr (1991): Etiologic factors, in: Tumors of the Newborn and Infant. Mosby Year Book, St. Louis, MO, pp. 6-12.
3. Satge, D (1989): Cytogenetic anomalies in neonatal and fetal solid tumors. First European Workshop on Cytogenetics and Molecular Genetics, October 13-15, 1988. Dijon, France. Cancer Genet Cytogenet 38:168(44).
4. Pascasio FM, Jesalva PS, Cruz EP, Alikpala S (1967): Extra large chromosome in adrenocortical carcinoma. Lancet I: 1107.
5. Nakamura Y, Nakashima H, Fukuda S, Hashimoto T, Maruyama M (1985): Bilateral cystic nephroblastomas and multiple malformations with trisomy 8 mosaicism. Hum Pathol 16:754-756.
6. Niss, R., Passarge E. (1976): Trisomy 8 restricted to cultured fibroblasts. J Med Genet 13:229-234.
7. Gafter U, Shabtai F, Kahn Y, Halbrecht I, Djaldetti M (1976): Aplastic anemia followed by leukemia in congenital trisomy 8 mosaicism. Clin Genet 9:134-142.
8. Riccardi VM, Humbert JR, Peakman D. (1978): Acute leukemia associated with trisomy 8 mosaicism and familial translocation 46, XY,t (7;20) (p13;p12). Am J Med Genet 2:5-21.
9. Cornaglia Ferraris P, Ghio R, Barabino A, Perlino GF, Maggio A, Parodi MT, Massimo L (1981): Diminished in vitro colony forming capacity of bone marrow cells in a case of chromosome 8 trisomy (mosaicism): criteria for "high risk" preleukemia syndrome. Boll Ist Sieroter Milan 60:15-21.
10. Palmer CG, Provisor AJ, Weaver DD, Hodes ME, Heerema N (1983): Juvenile chronic granulocytic leukemia in a patient with trisomy 8, neurofibromatosis and prolonged Epstein-Barr virus infection. J Pediatr 102:888-892.
11. Casali M, Maserati E, Giani S, Locatelli F, Angioni A, Balloni P, Miano C, Rosati D, Pasquali F (1992): Trisomia 8 constituzionale a mosaico e neoplasie. 7th Congresso Nazionale Federazione Italiana per lo studio delle malattie ereditarie. November 25-28, 1991, Genova, Italy, Pathologica 85:163.
12. Kapaun P., Kabisch H, Held KR, Walter TA, Hegewisch S, Zander AR (1993): Atypical chronic myelogenous leukemia in a patient with trisomy 8 mosaicism syndrome Ann Hematol 66:57-58.
13. Mastrangelo R, Tornesello A, Mastrangelo S, Zollino M, Neri G (1995): Constitutional trisomy 8 mosaicism evolving to primary myelodysplastic syndrome: a new subset of biologically related patients? Am J Hematol 48:67-68.
14. Hasle H, Clausen N, Pedersen B, Bendix-Hansen K (1995): Myelodysplastic syndrome in a child with constitutional trisomy 8 mosaicism and normal phenotype. Cancer Genet Cytogenet 79:79-81.
15. Toyofuku T, Mochizuki I, Kusama S (1987): Mediastinal germ cell tumor in trisomy 8. Eur J Respir Dis 70:245-249.
16. Lessick M, Israel J, Szego K, Wong P (1990): Leiomyosarcoma in a patient with trisomy 8 mosaicism. J Med Genet 27:643-644
17. Mace SE, McIntyre MN, Turk KB, Johnson WE (1978): The trisomy 9 syndrome: multiple congenital anomalies and unusual pathological findings. J Pediatr 92:446-448.
18. Djernes BW, Soukup SW, Bove KE, Wong KY (1976): Congenital leukemia associated with mosaic trisomy 9. J Pediatr 88:596-597.
19. Alimena G, DeCuia MR, Diverio D, Mancini M, Montefusco E (1987): Leukemias and constitutional chromosome pathology. Hematologica 72 (suppl 6):37-41.
20. Olson JM, Hamilton A, Breslow NE (1995): Non lip constitutional chromosome abnormalities in Wilms' tumor patients. Med Pediatr Oncol 24:305-309.
21. Keshgegian AA, Chatten J (1979): Nodular renal blastema in trisomy 13. Arch Pathol Lab Med 103:73-75.
22. Feingold M, Gheradi GJ, Simons C (1971): Familial neuroblastoma and trisomy 13. Amer J Dis Child 121:451.
23. Moerman P, Fryns J-P, Van Der Steen K, Kleczkowska A, Lauweryns J (1988): The pathology of trisomy 13 syndrome. Hum Genet 80:349-356
24. Mittelbach M, Szekely P (1935): Ein Fall von Neuroblastom des Nebennierenmarkes mit mehreren Missbildungen. Frankfurt Zeitsch Pathol 47:517-521.
25. Miller RW, Fraumeni JF Jr., Hill JA (1968): Neuroblastoma: epidémiologic approach to its origin. Amer J Dis Child 115:253-261.
26. Nevin NC, Dodge JA, Allen IV. (1971): Two cases of trisomy D associated with adrenal tumours. J Med Genet 9:119-122.
27. Gilbert LA, Dudley AW, Meisner L, Viseskul C, DeVenecia G (1977): New neurological findings in trisomy 13. Arch Pathol Lab Med 101:540-544.
28. Schade H, Schoeller L, Schultze KW (1962): D-Trisomie (Pätau-Syndrom) mit kongenitaler myeloischer Leukämie. Med Welt 5:2690-2692.
29. Dische MR, Garnder HA (1978): Mixed teratoid tumors of the liver and neck in trisomy 13. Am J Clin Pathol. 69:631-637.
30. Marsden HB, Birch JM, Swindell R (1981): Germ cell tumours of childhood: a review of 137 cases. J Clin Pathol. 34:879-883.
31. Isaacs H, Jr (1987): Congenital and neonatal malignant tumors. A 28 year experience at children's hospital of Los Angeles. Am J Pediat Hematol Oncol 9:121-129.
32. Hashida Y, Jaffe R, Yunis EJ (1983): Pancreatic pathology in trisomy 13: specificity of the morphologic lesion. Pediatr Pathol 1:169-178.
33. Maniglia AJ, Wolff D, Herques AJ (1970): Congenital deafness in 13-15 trisomy syndrome. Arch Otolaryng 92:181-188.
34. Miller RW, Fraumeni JF Jr, Manning MD (1964): Association of Wilms' tumor with aniridia, hemihypertrophy and other congenital malformations. N Engl J Med 270:922-927.
35. Geiser CF, Schindler AM (1969): Long survival in a male with 18-trisomy syndrome and Wilms' tumor Pediatrics 44:111-116.
36. Karayalcin G, Shanske A, Honigman R (1981): Wilms' tumor in a 13-year-old girl with trisomy 18. Am J Dis child 135:665-667.
37. Bove KE, Koffler H, McAdams AJ (1969): Nodular renal blastema. Definition and possible significance. Cancer 24:323-332.
38. Shanklin DR, Sotelo-Avila C (1969): In situ tumors in fetuses, newborns and young infants. Biol. Neonat 14:286-316.
39. Levert G, Gagne F (1970): Micro-nodules d'aspect blastémateux du cortex rénal chez le jeune enfant. Union Med Canada 99:1822-1824.
40. Robinson MG, McCorquodale MM (1981): Trisomy 18 and neurogenic neoplasia. J Pediatr 99:428-429.
41. Dasouki M, Barr M Jr (1987): Trisomy 18 and hepatic neoplasia. Am J Med Genet 27:203-205.
42. Mamlok V, Nichols M, Lockhart L, Mamlok R (1989): Trisomy 18 and hepatoblastoma. Am J Med Genet 33:125-126.
43. Tanaka K, Uemoto S, Asonuma K, Katayama T, Utsunomiya H, Akiyama Y, Sasaki MS, Ozawa K (1992): Hepatoblastoma in a 2-year-old girl with trisomy 18. Eur J Pediatr Surg 2:298-300.
44. Coerdt W, Rehder H, Gausmann I, Johannisson R, Gropp A (1985): quantitative histology of human fetal testes in chromosomal disease. Pediatr Pathol 3:245-259.
45. Bruch JF: Hôpital Robert Debré, Laboratoire de Biologie du Développement Paris. Personal communication.
46. Kinoshita M, Nakamura Y, Nakano R, Morimatsu M, Fukuda S, Nishimi Y, Hashimoto T (1989): Thirty-one autopsy cases of trisomy 18:clinical features and pathological findings. Pediatr Pathol 9:445-457.
47. Flenker H (1972): Connatal endocardial myxoma: case report and pathogenesis. Virchows Arch Path Anat A 356:353-358.
48. Anderson KR, Fiddler GI, Lie JT (1977): Congenital papillary tumor of the tricuspid valve. An unusual cause of right ventricular outflow obstruction in a neonate with trisomy E Mayo Clin Proc 52:665-669.
49. Rehder H (1982): Fetalpathologie im Rahmen pränataler Diagnostik. Verh Dtsch Ges Pathol 66:58-74.
50. Rosenfield RL, Breibart S, Isaacs H Jr, Klevit HD, Mellman WJ (1962): Trisomy of chromosomes 13-15 and 17-18: its association with infantile arteriosclerosis. Am J Med Sci 244:763-778.
51. Fabia J, Drolette M (1970): Malformations and leukemia in children with Down's syndrome. Pediatrics 45:60-70.
52. Saleun J-P, Ali D, Leroy J-P, Baret M, Balouet G, Castel Y (1975): Leucoblastose transitoire et dysembryoplasie rénale chez un trisomique 21. Ann Pediat 22:543-550.
53. Windham GC, Bjerkedal T, Langmark F (1985): A population-based study of cancer incidence in twins and in children with congenital malformations or low birth weight, Norway, 1967-1980. Am J Epidemiol 121:49-56.
54. Miller RW (1970): Neoplasia and Down's syndrome. Ann NY Acad Sci 171:637-644.
55. Hosoi H, Sawada T, Nakajima T, Kuroda H, Saida T, Sugimoto T, Tokiwa K, Ogita S (1989): A case of mosaic Down's syndrome concomitant with ganglioneuroma. J Pediatr Surg 24:210-211.
56. Taktikos A (1964): Association of retinoblastoma with mental defect and other pathological manifestations. Br J Ophtalmol 48:495-498.
57. Day RW, Wright SW, Koons A, Quigley M (1963): XXX 21-Trisomy and retinoblastoma. Lancet 11:154-155.
58. Jensen RD, Miller RW (1971): Retinoblastoma: epidemiologic characteristics. N E J Med 285:307-311.
59. Rethoré M-O, Saraux H, Prieur M, Dutrillaux B, Meer J-J, Lejeune J (1972): Syndrome 48, XXY, + 21 et retinoblastome. Arch Franc Pediatr 29:533-538.
60. Cernea P, Teodorescu F, Angheloni T (1973): Retinoblastome à mosaïcisme chromosomien 46XX/47XX G+. Ann Oculist 206:607-611.
61. Bentley D (1975): A case of Down's syndrome complicated by retinoblastoma and celiac disease. Pediatrics 56:131-133.
62. Wilson MG, Ebbin AJ, Towner JW, Spencer WH (1977): Chromosomal anomalies in patients with retinoblastoma. Clin Genet 12:1-8.
63. Jackson EW, Turner JH, Klauber MR, Norris FD (1968): Down's syndrome: variation of leukemia occurrence in institutionalized populations. J Chron Dis 21:247-253.
64. Slavc I, Urban C, Haas OA, Kroisel PM, Köller U (1991): Acute megakaryocytic leukemia in children. Clinical, immunologic and cytogenetic findings in two patients. Cancer 68:2266-2272.
65. Holland WW, Dool R, Carter CO (1962): The mortality from leukaemia and other cancers among patients with Down's syndrome (mongols) and among their parents. Br J Cancer 16:177-186.
66. Barber R, Spiers P (1964): Oxford survey of childhood cancers: Progress report II. Monthly Bull Minist Health London 23:46-52.
67. Miller RW (1969): Childhood cancer and congenital defects. A study of U.S. death certificates during the period 1960-1966. Pediat Res 3:389-397.
68. McCormick DP, Meyer WJ, Nesbit ME (1971): Coexistence of Hodgkin's disease and Down's syndrome. Am J Dis Child 122:71-73.
69. Oshimura M, Ohyashiki K, Tonomura A, Terada H (1981): A 14q+ chromosome in a malignant lymphoma in a patient with Down's syndrome. Cancer Genet Cytogenet 4:245-250.
70. Scholl T, Stein Z, Hansen H (1982): Leukemia and other cancers, anomalies and infections as causes of death in Down's syndrome in the United States during 1976. Dev Med Child Neurol 24:817-829.
71. Baird PA, Sadovnick AD (1988): Causes of death to age 30 in Down syndrome. Am J Hum Genet 43:239-248.
72. Wang N, Leung J, Warrier RP, Schorin M, Kirkpatrick D, Nowak MJ, Strand R (1987): Nonrandom chromosomal aberrations and clonal chromosomal evolution in acute leukemia associated with Down's syndrome. Cancer Genet Cytogenet 28:155-162.
73. Lorenzana AN, Schorin MA (1989): Non-Hodgkin's lymphoma in a neonate with Down's syndrome. Am J Pediatr Hematol Oncol 11:186-190.
74. Narod SA, Stiller C, Lenoir GM (1991): An estimate of the heritable fraction of childhood cancer. Br J Cancer 63:993-999.
75. Lorber BJ, Freeman SB, Hassold T, Ragab AH, Vega RA, Cockwell AE, Jacobs PA, Radford M, Doyle J, Dube ID, Zipursky A (1992): Characterization and molecular analysis of nondisjunction in 18 cases of trisomy 21 and leukemia. Genes Chrom Cancer 4:222-227.
76. Gurjal A, Rao S, Gladstone B, Nair CN, Pai SK, Kurkure PA, Advani SH (1993): Down's syndrome with Hodgkin's disease. Indian Pediat 30:684-687.
77. Iselius L, Jacobs P, Morton N (1990): Leukaemia and transient leukaemia in Down syndrome. Hum Genet 85:477-485.
78. Powers LW, Register MK (1991): Down syndrome and acute leukemia: epidemiological and genetic relationships. Lab Med 22:630-636.
79. Foucar K, Friedman K, Llewellyn A, McConnell T, Aisenbrey G, Argubright K, Ballinger L (1992): Prenatal diagnosis of transient myeloproliferative disorder via percutaneous umbilical blood sampling. Report of two cases in fetuses affected by Down's syndrome. Am J Clin Pathol 97:584-590.
80. Matsaniotis N, Karpouzas J, Economou-Mavrou C (1967): Hypothyroidism and seminoma in association with Down's syndrome. J Pediatr 70:810-812.
81. Li FP, Fraumeni JF Jr (1972): Testicular cancers in children: Epidemiologic characteristics. J Nat Cancer Inst 48:1575-1581.
82. Buffe D (1973): Fetoproteins and children's tumors. Gann Monograph on Cancer Res 14:117-128.
83. Oster J, Mikkelsen M, Nielsen A (1975): Mortality and life-table in Down's syndrome. Acta Paediatr Scand 64:322-326.
84. Sakashita S, Koyanagi T, Tsuji I, Arikado K, Matsuno T (1980): Congenital anomalies in children with testicular germ cell tumor. J Urol 124:889-891.
85. Kamidono S, Takada K, Ishigami J, Furumoto M, Urano Y (1985): Giant seminoma of undescended testis in Down syndrome. Urology 25:637-640.
86. Braun DL, Green MD, Rausen AR, David R, Wolman SR, Greco MA, Muggia FM (1985): Down's syndrome and testicular cancer: a possible association. Am J Pediat, Hematol Oncol 7:208-211.
87. Sasagawa I, Kazama T, Umeda K, Kohno T, Katayama T, Miwa A (1986): Down's syndrome associated with seminoma. Urol Int 41:238-240.
88. Sasagawa I, Nakada T, Hashimoto T, Ishigooka M, Izumiya K, Kubota Y, Tomaru M (1993): Hormone profiles and contralateral testicular histology in Down's syndrome with unilateral testicular tumor. Arch Androl 30:93-98.
89. Dexeus FH, Logothetis CJ, Chong C, Sella A, Ogden S (1988): Genetic abnormalities in men with germ cell tumors. J Urol 140:80-84.
90. Mann JR, Pearson D, Barrett A, Raafat F, Barnes JM, Wallendszus KR (1989): Results of the United Kingdom children's cancer study group's malignant germ cell tumor studies. Cancer 63:1657-1667.
91. Frey P, Fliegel C, Herzog B (1989): Testicular tumours in infancy and childhood. A review of 10 germ cell tumours and 10 non germ cell tumours. Z Kinderchir 45:229-234.
92. Jacobsen GK, Henriques UV (1992): A fetal testis with intratubular germ cell neoplasia (ITGCN). Modern Pathol 5:547-549.
93. Gesmundo R, Bevilacqua A, Gandini R, Maiullari E, Moro G (1988): Su di un caso di disgerminoma ovarico in syndrome di Down. Min Ginecol 40:277-280.
94. Ganick DJ, Gilbert EF, Opitz JM (1979): Teratomas in children and young adults. Med Pediat Oncol 6:235-242.
95. Linder D, Hecht F, Kaiser McCaw B, Campbell JR (1975): Origin of etragonadal teratomas and endodermal sinus tumours. Nature 254:597-598.
96. Vandooren M, Boulard P, Jobart P, Chantcpic G (1959): Un cas de tératome rétropéritonéal volumineux du nourrisson. Mem Acad Chir 85:304-307.
97. Bowen B, Ros PR, McCarthy MJ, Olmsted WW, Hjermstad BM (1987): Gastrointestinal teratomas: CT and US appearance with pathologic correlation, radiology 162:431-433.
98. Fountzilas G, Betsis D, Nikopoulos A, Zaramboukas T, Dimitriadis A, Tourkantonis A (1994): Extragonadal choriocarcinoma in a patient with Down syndrome. Am J Clin Oncol 17:452-455.
99. Komiya K, Iwamoto H, Misugi K (1975): A case of cerebellar tumor associated with Down's syndrome. Congenital Anomalies 15:212-213.
100. Nakato H, Kuwabara S, Maesako N, Inomata H, Ishimoto F, Hashida K, Kubota T (1982): A case of Down's syndrome complicated by teratoma of the third ventricle of the brain. Noshinkei 34:145-150.
101. Yamasaki S, Hamazaki Y (1985): A case of brain tumor associated with Down's syndrome. Arch Jpn Chir 54:305-313.
102. Hozeku Y, Okada A, Kanehisa Y, Nagamatsu K (1987): Down syndrome associated with radio-sensitive brain tumor. A case report. Neurol Med 26:86-89.
103. Fujita T, Yamada K, Saitoh H, Itoh S, Nakai O (1992): Intracranial germinoma and Down's syndrome. Neurol Med Chir (Tokyo) 32:163-165.
104. Oshita N, Yamashita K, Gotou K, Nagata I, Ueda H, Mitani T (1993): A case of endodermal sinus tumor in the basal ganglia associated with Down's syndrome. No Shinkei Geka 21:345-349.
105. Butterworth T, Strean LP, Beerman H, Wood MG (1964): Syringoma and mongolism. Arch Dermatol 90:483-487.
106. Turner JH (1962): The mongoloid phenotype: its incidence, etiology and association with leukemia and other neoplastic disease. Thesis, Ann Arbor Michigan, pp. 82-84.
107. Fraumeni JF Jr, Miller RW, Hill JA (1968): Primary carcinoma of the liver in childhood: an epidémiologic study. J Natl Cancer Inst 40:1087-1099.
108. Kuni CC (1973): Extra-adrenal pheochromocytoma with metastasis in Down's syndrome. J Pediatr 83:835-836.
109. Jancar MP, Jancar J (1976): Cancer and mental retardation. Bristol Med-Chir J 92:3-7.
110. Ammann J, Schärli A (1977): Congenital duodenal membrane as cause for hiatus hernia, stricture of the oesophagus, and stricture carcinoma in an adult with Down's syndrome. Prog Pediatr Surg 10:33-34.
111. Nakano J, Muto M, Arikawa K, Hirota T, Asagami C (1993): Acral lentiginous melanoma associated with Down's syndrome. J Dermatol 20:59-60.
112. Kopec AV, Levine N (1979): Generalized connective tissue nevi and ichthyosis in Down's syndrome. Arch, Dermatol. 115:623-624.
113. Morgan JR (1989): A case of Down's syndrome, insulinoma and anorexia. J Ment Def Res 33:185-187.
114. Morayati SJ, Wagner CW (1990): Down's syndrome with pituitary adenoma. A case report. Del Med Jrl 62:1363-1365.
115. Hori A, Walter GF, Haas J, Becker H (1992): Down syndrome complicated by brain tumors: case report and review of the literature. Brain Dev 14:396-400.
116. Zagzag D, Miller DC, Cangiarella J, Allen JC, Greco MA (1992): Brainstem glioma after radiation therapy for acute myeloblastic leukemia in a child with Down syndrome. Cancer 70:1188-1193.
117. Wilimas J, Barrett G, Pratt C (1977): Osteosarcoma in 2 very young children. Clin Pediatr 16:548-551.
118. Borja A, Ninane J, Delloye C, Vermylen C, Cornu G, Denayer P (1991): Osteosarcoma in a child with Down syndrome. Treatment with systemic chemotherapy and "ex-vivo" treatment of the bone. 23rd meeting SIOP Sept 30-Oct 4, 1991. Rhodes Med Pediatr Oncol 19:361 (No 85).
119. Bridge JA, Neff JR, Borek DA, Hackbarth DA (1990): Primary skeletal Ewing's sarcoma in Down syndrome. Cancer Genet Cytogenet 47:61-68.
120. Casorzo L, Fessia L, Sapino A, Ponzio G, Bussolati G (1989): Extraskeletal Ewing's tumor with translocation t(11;22) in a patient with Down syndrome. Cancer Genet Cytogenet 37: 79-84.
121. Foley JF, Lemon HM, (1968): Down's syndrome associated with an intracranial rhabdomyosarcoma and relative hypopituitarism. Nebraska State Med J 53:384-388.
122. Singh RVP, Suys S, Yeh JS, Campbell DA, Broome JC (1993): Spinal intramedullary cavernous angioma in a patient with Down's syndrome. Clin Neurol Neurosurg 95:55-58.
123. Martin S, Pitcher D, Tschen J, Wolf JE (1980): Reactive angioendotheliomatosis J Am Acad Dermatol 2:117-123.
124. Claros P, Viscasillas S, Claros A Sr, Claros A Jr (1985): Lymphangioma of the larynx as a cause of progressive dyspnea. Int J Pediatr Otorhinolaryngol 9:263-268.
125. Griffiths GC (1962): Primary tumours of the heart. Clin Radiol 13:183-194.
126. Irwin GAL, Mehta GB, Neil EE, Cancroft E (1977): Massive retroperitoneal lipoma in a mongoloid child. Clin Pediatr 16:195-196.
127. Smith CW, Murray GF, Wilcox BR (1976): Intramural esophageal hamartoma. An unusual cause of progressive stricture in a child. J Thorac Cardiovasc Surg 72:315-318.
128. Everett C, Volberg F, Ulshen M, Murray G (1980): Intramural esophageal hamartoma: a report of two cases and review of the literature. Gastrointest Radiol 5:317-319.
129. Rose JS, Kassner EG, Jurgens KH, Farman J (1975): Congenital oesophageal strictures due to cartilaginous rings Br J Radiol 48:16-18.
130. Stewart A, Webb J, Hewitt D (1958): A survey of childhood malignancies. Brit Med J 1:1495-1508.
131. Jonakin WL, Hensley MF (1983): Optic glioma and Down's syndrome. J Am Osteopath Assoc 82:806.
132. Deaton JG (1973): The mortality rate and causes of death among institutionalised mongols in Texas. J Ment Defic Res 17:117-122.
133. Fukushima Y, Kuroki Y (1985): Down's syndrome, pediatric Mook, 38, in Baba K, Kobayashi N (eds). Clinical Findings. Kanahara Press (Tokyo), pp. 1-17.
134. Carter CO (1958): A life-table for mongols with the causes of death. J Ment Defic Res 2:64-74.
135. Potter EL (1961): Pathology of the fetus and infant. Year Book Med Publ, St. Louis, MO, p. 199.
136. Beckwith JB (1982): Histopathological aspects of renal tumors in children, pp 1-14 in Renal Tumors: Proceedings of the First International Symposium on Kidney Tumors. Alan R. Liss, New York.
137. Beckwith JB (1993): Precursor lesions of Wilms tumor: clinical and biological implications. Med Pediatr Oncol 21:158-168.
138. Barson AJ (1978): Congenital neoplasia: the Society's experience. Arch Dis Child 53:436.
139. Warkany J (1975): Trisomy 13-15 D1 and Turner syndrome, in congenital malformations. Year Book Med Publ, St. Louis, MO, pp. 296-303, 1123-1136.
140. Zipursky A, Poon A, Doyle J (1992): Leukemia in Down syndrome: a review. Pediatr Hematol Oncol 9:139-149.
141. Beckwith JB, Perrin EV (1963): In situ neuroblastomas: a contribution to the natural history of neural crest tumors. Am J Pathol 43:1089-1104.
142. Weinstein HJ (1978): Congenital leukaemia and the neonatal myeloproliferative disorders associated with Down's syndrome. Clin Haematol 7:147-154.
143. Ruchelli ED, Uri A, Dimmick JE, Bove KE, Huff DS, Duncan LM, Jennings JB, Witzleben CL (1991): Severe perinatal liver disease and Down syndrome: an apparent relationship. Hum Pathol 22:1274-1280.
144. Fujinaga M, Shepard, TH, Fitzsimmons J (1990): Trisomy 13 in the fetus. Teratology 41:233-238.
145. Opitz JM, Gilbert-Barness EF (1990): Reflections on the pathogenesis of Down syndrome. Am J Med Genet Suppl 7:38-51.
146. Suda J, Eguchi M, Ozawa T, Furukawa T, Hayashi Y, Kojima S, Maeda H, Tadokoro K, Sato Y, Miura Y, Ohara A, Suda T (1988): Platelet peroxidase-positive blast cells in transient myeloproliferative disorder with Down's syndrome Br J Haematol 68:181-187.
147. Abe K, Kajii T, Niikawa N (1989): Disomic homozygosity in 21-Trisomic cells: a mechanism responsible for transient myeloproliferative syndrome. Hum Genet 82:313-316.
148. Ghosh K (1992): Transient abnormal myelopoiesis in Down's syndrome. Are some of them truly leukaemic? Leuk Res 16:545-546.
149. Mertens F, Sallerfors B, Heim S, Johansson B, Kristoffersson U, Malm C, Mitelman F (1991): Trisomy 13 as a primary chromosome aberration in acute leukemia. Cancer Genet Cytogenet 56:39-44.
150. Prigogina EL, Puchkova GP, Mayakova SA (1988): Nonrandom chromosomal abnormalities in acute lymphoblastic leukemia of childhood. Cancer Genet Cytogenet 32:183-203.
151. Timmons CF, McGavran L, Unterkircher L, Beckwith JB, Wilson HL (1989): Hyperdiploidy including trisomy 8 in a cystic partially differentiated nephroblastoma. Cancer Genet Cytogenet 41:79-85.
152. Surti U, Hoffner L, Chakravarti A, Ferrell RE (1990): Genetics and biology of human ovarian teratomas, I cytogenetic analysis and mechanism of origin Am J Hum Genet 47:635-643.
153. Sansone R, Pierluigi M, Carobbi S, Cominetti M, Strigini P (1990): Disomic homozygosity and leukemia in Down's syndrome. Hum Genet 85:386.
154. Epstein CJ (1988): Specificity versus nonspecificity in the pathogenesis of aneuploid phenotypes Am J Med Genet 29:161-165.
155. Vogels A, De Smet L, van den Berghe H, Fryns JP (1994): Thrombocytopenia and cleft hand in monosomy 21. Genet Couns 5:67-71.
156. Christensen RD (1989): Hematopoiesis in the fetus and neonate. Pediatr Res 26:531-535.
157. Thilaganathan B, Tsakonas D, Nicolaides K (1993): Abnormal fetal immunological development in Down's syndrome Br J Obstet Gynaecol 100:60-62.
158. Hannan MA, Waghray M, Sigut D, Ozand PT (1992): Increased radiosensitivity of cell lines derived from a Down's syndrome patient with ocular telangiectasia. J Child Neurol 7(suppl):S83-S87.
159. O'Brien RL, Poon P, Kline E, Parker JW (1971): Susceptibility of chromosomes from patients with Down's syndrome to 7, 12, dimethylbenzanthracene induced aberrations in vitro. Int J Cancer 8:202-210.
160. Higurashi M, Tada A, Miyahara S, Hirayama M (1976): Chromosome damage in Down's syndrome induced by chickenpox infection. Pediatr Res 10:189-192.
161. Todaro GJ, Martin GM (1967): Increased susceptibility of Down's syndrome fibroblasts to transformation by SV 40. Proc Soc Exp Biol Med 124:1232-1236.
162. Knudson AG (1971): Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820-823.
163. Matsunaga E (1979): Hereditary retinoblastoma: host resistance and age at onset. J Natl Cancer Inst 63:933-939.
164. Bolande RP, Vekemans MJJ (1983): Genetic models of carcinogenesis. Hum Pathol 14:658-662.