Clinical results of hypoxic cell radiosensitisation from hyperbaric oxygen to accelerated radiotherapy, carbogen and nicotinamide

British Journal of Cancer

Volumn 74, Issue SUPPL. XXVII, 1996, Pages

  Saunders, M ^a   Dische, S ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

CHART; Nicotinamide; Radiosensitisers; Radiotherapy

Indexed keywords

CARBOGEN; NICOTINAMIDE; CARBON DIOXIDE; OXYGEN; RADIOSENSITIZING AGENT;

CANCER RADIOTHERAPY; CELL PROLIFERATION; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; HUMAN; HYPERBARIC OXYGEN; HYPOXIC CELL; META ANALYSIS; PRIORITY JOURNAL; RADIOSENSITIZATION; RANDOMIZED CONTROLLED TRIAL; BLOOD TRANSFUSION; CELL HYPOXIA; NEOPLASM; REVIEW;

BLOOD TRANSFUSION; CARBON DIOXIDE; CELL HYPOXIA; HUMANS; HYPERBARIC OXYGENATION; NEOPLASMS; NIACINAMIDE; OXYGEN; RADIATION-SENSITIZING AGENTS;

EID: 0029976702     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (48)

1. ADAMS GE AND DEWEY DL. (1963). Hydrated electrons and radiobiological sensitization. Biochem. Biophys. Res. Commun., 12, 473-477.
2. ADAMS GE AND STRATFORD IJ. (1995). Exploitation of hypoxia for cancer therapy, MRC Radiobiology Unit. In Progress in Radio-Oncology V. Kogelnik HD. (ed.) pp.461-468. Monduzzi Editore, International Proceedings Division: Bologna, Italy.
3. AWWAD HK, ABD EL MONEIM H, ABD EL BAKI H, OMAR S, EL MERZABANI M AND FARAG H. (1983). The topical use of misonidazole. In 13th International Cancer Congress, Part D, pp. 303-316. Alan R Liss Inc: New York.
4. BALMUKHANOV SB, BEISEBAEV AA, AITKOOLOVO ZI, MUSTAPHIN JS, PHILIPPENKO VI, RISHMUHAMEDOVA, RS AISAROVA AM AND ABDRAHMANOV JN. (1989). Intratumoural and parametrial infusion of metronidazole in the radiotherapy of uterine cervix cancer: preliminary report. Int. J. Radiat. Oncol. Biol. Phys., 16, 1061-1063.
5. BROWN JM. (1979). Evidence of acutely hypoxic cells in mouse tumours and a possible method of re-oxygenation. Br. J. Radiol., 52, 650-656.
6. BUSH RS, JENKIN RDT, ALT WEC, BEALE FA, BEAN H, DEMBO AJ AND PRINGLE JF. (1978). Definitive evidence for hypoxic cells influencing cure in cancer therapy. Br. J. Cancer 37 (suppl. III), 302-306.
7. CHASSAGNE D, SANCHO-GARNIER H, CHARREAU I, ESCHWEGE F AND MALAISE EP. (1991). Progress report of a phase II and a phase III trial with etanidazole (SR-2508): a multi-centre European study. Radiother. Oncol., suppl. 20, 121-127.
8. CHURCHILL-DAVIDSON I, SANGER C AND THOMLINSON RH. (1955). High-pressure oxygen and radiotherapy. Lancet, 1, 1091-1095.
9. CHURCHILL-DAVIDSON I, FOSTER CA, WIERNIK G, COLLINS CD, PIZZEY NCD, SKEGGS DBL AND PURSER PR. (1966). The place of oxygen in radiotherapy. Br. J. Radiol., 39, 321-331.
10. DISCHE S. (1978). Hyperbaric oxygen. The Medical Research Council trials and their clinical significance. Br. J. Radiol., 51, 888-894.
11. DISCHE S. (1991a). Radiotherapy and anaemia the clinical experience. Radiother. Oncol., suppl. 20, 35-40.
12. DISCHE S. (1991b). What have we learnt from the work with hyperbaric oxygen? Radiother. Oncol., suppl. 20, 71-74.
13. DISCHE S, GRAY AJ AND ZANELLI GD. (1976). Clinical testing of the radiosensitizer Ro 07-0582. II. Radiosensitization of normal and hypoxic skin. Clin. Radiol., 27, 159-166.
14. DISCHE S, ROJAS A, RUGG T, HONG A AND MICHAEL BD. (1992). Carbogen breathing: a system for use in man. Br. J. Radiol., 65, 87-90.
15. DISCHE S, SAUNDERS MI, DUNPHY EP, BENNETT MH, DES ROCHERS C, STRATFORD MRL, MINCHINTON AI AND ORCHARD RA. (1986). Concentrations achieved in human tumours after administration of misonidazole, SR-2508 and RO 03-8799. Int. J. Radiat. Oncol. Biol. Phys., 12, 1109-1111.
16. DISCHE S, MACHIN D AND CHASSAGNE D. (1993). A trial of Ro 03-8799 (pimonidazole) in carcinoma of the uterine cervix: an interim report from the Medical Research Council Working Party on advanced carcinoma of the cervix. Radiother. Oncol., 26, 93-103.
17. EVANS R, KIMLER BF, MORANTZ RA, VATS TS, GEMER LS, LISTON V AND LOWE N. (1990). A phase I/II study of the use of Fluosol as an adjuvant to radiation therapy in the treatment of primary high-grade brain tumours. Int. J. Radiat. Oncol. Biol. Phys. 19, 415-420.
18. GARCIA-ANGULO AH. (1988). Radiosensitizer metronidazole plus standard radiotherapy for advanced cervical carcinoma. In Hyperthermic Oncology Vol. 1, Sugahara T. (ed.) pp. 633-636. Taylor and Francis: London, Philadelphia.
19. HAUSTERMANS K, VAN DER KOGEL AJ, VANACKER B AND VAN DER SCHEUREN E. (1994). Influence of combined use of nicotinamide and carbogen on rat spinal cord tolerance. Radiother. Oncol., 31, 123-128.
20. HORSMAN MR, CHAPLIN DJ AND BROWN JM. (1989). Tumour radiosensitization by nicotinamide: a result of improved perfusion and oxygenation. Radiat. Res., 118, 139-150.
21. HORSMAN MR, HOYER M, HONESS D, BROWN JMM AND OVERGAARD J. (1993). Nicotinamide pharmacokinetics in humans and mice: a comparative assessment and the implications for radiotherapy. Radiother.Oncol., 27, 131-139.
22. KJELLEN E, JOINER MC, COLLIER JM JOHNS H AND ROJAS AM. (1991). A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated x-ray treatments. Radiother. Oncol., 22, 81-91.
23. LAVEY RS AND DEMPSEY WH. (1993). Erythropoietin increases haemoglobin in cancer patients during radiation therapy. Int. J. Radiat. Oncol. Biol. Phys., 20, 1147-1152.
24. LAWRENCE VM, WARD R, DENNIS I AND BLEEHEN NM. (1994). A Pilot Study of Nicotinamide and Carbogen Breathing in Man. ARCON, Second Workshop 3-5 March 1994. Gray Laboratory, Mount Vernon Hospital.
25. LEE DJ, PAJAK TF, MARCHIAL VA, FU K, ROTMAN M, COOPER JS, ORTIZ HG, BEITLER JJ, ABRAMS RA, CURRAN WJ, COLEMAN CN AND WASSERMAN TH. (1995). Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole (SR-2508) with radiotherapy alone for locally advanced head and neck carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 32, 567-576.
26. LUSTIG R, LOWE N, PROSNITZ L, SPAULDING M, COHEN M, STITT J AND BRANNON R. (1990). Fluosol and oxygen breathing as an adjuvant to radiation therapy in the treatment of locally advanced non-small cell carcinoma of the lung: results of a phase I/II study. Int. J. Radiat. Oncol. Biol. Phys., 15, 97-102.
27. OVERGAARD J. (1994). Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumours. Oncol. Res., 509-518.
28. OVERGAARD J. (1995). Modification of hypoxia - from Gottwald Schwarz to nicotinamide: have we learned the lesson? Danish Cancer Society. In Progress in Radio-Oncology V. Kogelnik HD (ed.) pp. 469-475. Monduzzi Editore, International Proceedings Division: Bologna, Italy.
29. OVERGAARD J, HANSEN HS, ANDERSEN AP, HJELM-HANSEN M, JORGENSEN K, BASTHOLT L, BERTHELSEN A, HAMMER R AND PEDERSEN M. (1989). Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: report from the Dahanca 2 study. Int. J. Radiat. Oncol. Biol. Phys., 16, 1065-1068.
30. OVERGAARD J, SAND HANSEN H, OVERGAARD M, JORGENSON K, BASTHOLT L, BERTHELSEN A AND PEDERSEN M. (1991). The Danish Head and Neck Cancer study group (Dahanca) randomized trials with hypoxic radio-sensitizers in carcinoma of the larynx and pharynx. In Radiation Research. A Twentieth-Century Perspective. Volume II. Dewey WC, Edington M, Fry RJM, Hall EJ and Whitmore GF. (eds), pp. 573-577. Congress Proceedings, ICRR: Toronto.
31. RIDER WD, KERSESTECI AG AND HAWKINS NV. (1969). A trial of 'orthobaric oxygen' as an adjunct of radiotherapy of bladder cancer. In Proceedings of Radiological Society of North America. 5th Scientific Assembly. Chicago.
32. ROJAS A. (1992). ARCON: accelerated radiotherapy with carbogen and nicotinamide. Br. J. Radiol., suppl. 24, 174-178.
33. ROJAS A, CARL U AND REGHEBI K. (1990). Effect of normobaric oxygen on tumour radiosensitivity: fractionated studies. Int. J. Radiat. Oncol. Biol. Phys., 18, 547-553.
34. ROJAS A, HODGKISS RJ, STRATFORD MRL, DENNIS MF AND JOHNS H. (1993a). Pharmacokinetics of varying doses of nicotinamide and tumour radiosensitization with carbogen and nicotinamide: clinical considerations. Br. J. Cancer, 65, 1115-1126.
35. ROJAS A, DENEKAMP J AND JOINER MC. (1993b). ARCON: accelerated radiotherapy with carbogen and nicotinamide. In Bioreductive Drugs, Sensitizers, Oxygen and Radiotherapy. Dobrowsky W. (ed.) pp. 101-104. University Faculty Press: Vienna.
36. ROSE C, LUSTIG R, McINTOSH N AND TEICHER B. (1986). A clinical trial of Fluosol DA 20% in advanced squamous cell carcinoma of the head and neck. Int. J. Radiat. Oncol. Biol. Phys., 12, 1325-1327.
37. RUBIN P, HANLEY J, KEYS HM, MARCIAL V AND BRADY L. (1979). Carbogen breathing during radiation therapy. Int. J. Radiat. Oncol. Biol. Phys., 5, 1963-1970.
38. SAUNDERS MI, DISCHE S, ANDERSON P AND FLOCKHART IR. (1978). The neurotoxicity of misonidazole and its relationship to dose, half-life and concentration in the serum. Br. J. Cancer, 37 (suppl. III), 268-270.
39. SAUNDERS MI AND HOSKIN PJ. (1995). Accelerated radiotherapy carbogen and nicotinamide from mice to man. In Progress in Radio-Oncology V. Kogelnik HD (ed.) pp. 477-483. Monduzzi Editore, International Proceedings Division: Bologna, Italy.
40. SOTAK CH, HEES PS, HUANG HN, HUNG MH, KRESPAN CG AND REYNOLDS S. (1993). A new perfluorocarbon for use in Fluosol-19 magnetic resonance imaging and spectroscopy. Magn. Res. Imaging, 29, 188-195.
41. STRATFORD MRL, ROJAS AM, HALL DW, DENNIS MF, DISCHE S, JOINER MC AND HODGKISS RJ. (1992). Pharmacokinetics of nicotinamide and its effect on blood pressure, pulse and body temperature in normal human volunteers. Radiother. Oncol., 25, 37-42.
42. STRATFORD MRL, DENNIS MF, HOSKIN PJ, SAUNDERS MI, HODGKISS RJ AND ROJAS AM. (1996). Nicotinamide pharmacokinetics in normal volunteers and patients undergoing palliative radiotherapy. Acta Oncol. 35, 213-219.
43. THOMLINSON RH, DISCHE S, GRAY AJ AND ERRINGTON LM. (1976). Clinical testing of the radiosensitizer Ro 07-0582 III. Response of tumours. Clin. Radiol., 27, 167-174.
44. URTASON RC, BAND P, CHAPMAN JD, FELDSTEIN, ML, MIELKE B AND FRYER C. (1976). Radiation and high dose metronidazole in supratentorial glioblastomas. N. Engl. J. Med., 294, 1364-1367.
45. URTASON R, FIELDSTEIN ML, PARTINGTON J, TANASICHUK HJ, MILLER JDR, RUSSELL DB, AGBOOLA O AND MIELKE B. (1982). Radiation and nitroimidazoles in supratentorial high grade gliomas - a second clinical trial. Br. J. Cancer, 46, 101-108.
46. VAN DER MAAZEN RWM, THIJSSEN, HOM, KAANDERS JHAM, DE KOSTER A, KEYSER A, PRICK MJJ, GROTENHUIS JA, WESSELING P AND VAN DER KOGEL AJ. (1995). Conventional radiotherapy combined with carbogen breathing and nicotinamide for malignant gliomas. Radiother. Oncol., 35, 118-122.
47. WEISSBERG JB, SON YH, PAPAC RJ, SASAKI C, FISCHER DB, LAWRENCE R, ROCKWELL S, SARTORELLI AC AND FISCHER JJ. (1989). Randomized clinical trial of mitomycin-C as an adjuvant to radiotherapy in head and neck cancer. Int. J. Radiat. Oncol. Biol. Phys., 17, 3-9.
48. ZACKRISSON B, FRANZEN L, HENRIKSSON R, LITTBRAND B, STRATFORD M, DENNIS M, ROJAS A AND DENEKAMP J. (1994). Acute effects of accelerated radiotherapy in combination with carbogen breathing and nicotinamide (ARCON). Acta Oncol., 33, 377-381.