Endothelial dysfunction in the San Juan hypertensive rat: Possible role of the nitric oxide synthase

Journal of Cardiovascular Pharmacology

Volumn 27, Issue 6, 1996, Pages 802-808

  Crespo, María J ^a   Escobales, Nelson ^a   Rodríguez Sargent, Carmen ^b  

^a UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^b VA MEDICAL CENTER   (Puerto Rico)

Author keywords

A23187; Acetylcholine induced relaxation; Age; Endothelium derived relaxing factor; Hypertension; Nitric oxide; San Juan hypertensive rat

Indexed keywords

ACETYLCHOLINE; CALCIMYCIN; ENDOTHELIUM DERIVED RELAXING FACTOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; NORADRENALIN; SUPEROXIDE DISMUTASE;

ADOLESCENT; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM LESION; HYPERTENSION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM; VASCULAR RING; VASODILATATION;

ACETYLCHOLINE; AGE FACTORS; ANIMALS; AORTA; CALCIMYCIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; IONOPHORES; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; RATS; RATS, WISTAR;

EID: 0029975646     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199606000-00006     Document Type: Article

References (30)

1. Rubanyi GM. The role of endothelium in cardiovascular homeostasis and diseases. J Cardiovasc Pharmacol 1993;22 (suppl 4):S1-14.
2. Davies MG, Hagen P. The vascular endothelium. Ann Surg 1993;218:593-609.
3. Furchgott RF, Zawadzki JV. The obligatory role of the endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6.
4. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991;43:109-1422.
5. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthetize nitric oxide from L-arginine. Nature 1988; 333:664-6.
6. Moncada S. The 1991 Ulf von Euler Lecture. The L-arginine:nitric oxide pathway. Acta Physiol Scand 1992;145: 201-27.
7. Pickering GW. Peripheral resistance in persistent hypertension. Clin Sci 1936;2:209-22.
8. Lockette W, Otsuka Y, Carretero OA. The loss of endothelium dependent vascular relaxation in hypertension. Hypertension 1986;8(suppl II):II61-6.
9. Lüscher TF, Vanhoutte PM. Endothelium-dependent contraction to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension 1986;8:344-8.
10. Lüscher TF, Raij L, Vanhoutte PM. Endothelium-dependent responses in normotensive and hypertensive Dahl rats. Hypertension 1987;9:157-63.
11. Hoshino J, Sakamaki T, Nakamura T, et al. Exaggerated vascular response due to endothelial dysfunction and role of the renin-angiotensin system at early stage of renal hypertension in rats. Circ Res 1994;74:130-8.
12. Panza JA, Casino PR, Kilcoyne CM, Quyyumi AA. Role of endothelium-derived nitric oxide in the abnormal endothelium dependent vascular relaxation of patients with essential hypertension. Circulation 1993;87:1468-74.
13. Panza JA, Quyyumi AA, Brush JE Jr, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990;323:22-7.
14. Panza JA, Quyyumi AA, Callahan TS, Epsein SE. Effect of antihypertensive treatment of endothelium-dependent vascular relaxation in patients with essential hypertension. J Am Coll Cardiol 1993;21:1145-51.
15. Lindler I, Kioswski W, Buhler FR, Lüscher TF. Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo: blunted response in essential hypertension. Circulation 1990;81:1762-7.
16. Cockcroft JR, Chowienczyk PJ, Benjamin N, Ritter JM, Phil D. Preserved endothelium-dependent vasodilation in patients with essential hypertension. N Engl J Med 1994;330: 1036-40.
17. Rubanyi GM. Cardiovascular significance of endothelium derived vasoactive factors, 1st ed. Mount Kisco, NY: Futura, 1991.
18. Hypertension prevalence and the status of awareness, treatment, and control in the United States. Final report of the Subcommittee on Definition and Prevalence of the 1984 Joint Committee. Hypertension 1985;7:457-68.
19. SHEP Cooperative Research Group: prevention of stroke by antihypertensive drug treatment in older persons with isolated systemic hypertension. JAMA 1991;265:3255.
20. Dinerman JL, Lowenstein CJ, Snyder SH. Molecular mechanisms of nitric oxide regulation. Circ Res 1993;73:217-22.
21. Rodriguez-Sargent C, Cangiano JL, Fernandez-Repollet E, Estape-Wainwright E, Torres-Negron I, Martinez-Maldonado M. A new model of genetic hypertension in rats with superficial glomeruli. J Hypertens 1988;6(suppl 4):S29-32.
22. Konishi M, Su C. Role of endothelium in dilator responses of spontaneously hypertensive rat arteries. Hypertension 1983; 5:881-6.
23. Voorde JV, Leusen I. Endothelium-dependent relaxation of aortic rings from hypertensive rats. Am J Physiol 1986;250: H711-7.
24. Mayhan WG, Faraci FM, Heistad DD. Impairment of endothelium-dependent responses of cerebral arterioles in chronic hypertension. Am J Physiol 1987;253:H1435-40.
25. Zeiher AM, Drexler H, Saurbier B, Just H. Endothelium-mediated coronary blood flow modulation in humans. J Clin Invest 1993;92:652-62.
26. Vita JA, Treasure CB, Nabel EG, et al. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 1990;81:482-90.
27. Yasue H, Matsuyama K, Okumura K, Morikami Y, Ogawa H. Responses to angiographically normal human coronary arteries to intracoronary injection to acetylcholine by age and segments. Circulation 1990;81:482-90.
28. Rubanyi GM, Kauser K, Graser T. Effect of cilazipril and indomethacin on endothelial dysfunction in the aortas of spontaneously hypertensive rats. J Cardiovasc Pharmacol 1993;22(suppl 5):S23-30.
29. Lee L, Webb C. Endothelium-dependent relaxation and L-arginine metabolism in genetic hypertension. Hypertension 1992;19:435-41.
30. Vallance P, Calver A, Collier J. Vascular endothelium in diabetes and hypertension. J Hypertens 1992;10(suppl I): S25-9.