Evaluation of cytogenetic conversion to Ph- haemopoiesis in long-term bone marrow culture for patients with chronic myeloid leukaemia on conventional hydroxyurea therapy, on pulse high-dose hydroxyurea and on interferon-alpha

British Journal of Haematology

Volumn 93, Issue 4, 1996, Pages 869-877

  Coutinho, L H ^a   Brereton, M L ^b   Santos, A M W ^a   Ryder, W D J ^a   Chang, J ^a   Harrison, C J ^a   Liu Yin, J A ^b   Dexter, T M ^a   Testa, N G ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b MANCHESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

CML; Hydroxyurea; Interferon; LTBMC; Ph cells

Indexed keywords

ALPHA INTERFERON; HYDROXYUREA;

ADOLESCENT; ADULT; AGED; ARTICLE; BONE MARROW CULTURE; CHILD; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOGENETICS; FEMALE; HEMATOPOIESIS; HUMAN; MAJOR CLINICAL STUDY; MALE; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

ADULT; AGED; AGED, 80 AND OVER; BONE MARROW; FEMALE; HEMATOPOIESIS; HUMANS; HYDROXYUREA; INTERFERON-ALPHA; LEUKEMIA, MYELOID, PHILADELPHIA-NEGATIVE; MALE; MIDDLE AGED; TUMOR CELLS, CULTURED;

EID: 0029975376     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.d01-1733.x     Document Type: Review

References (26)

1. Allan, N.C., Richards, S.M. & Shepherd, P.C.A., on behalf of the UK Medical Research Council's Working Parties for Therapeutic Trials in Adult Leukaemia (1995) UK Medical Research Council randomised, multicentre trial of interferon-α1 for chronic myeloid leukaemia: improved survival irrespective of cytogenetic response. Lancet, 345, 1392-1397.
2. Andrews, R.G., Singer, J.W. & Berstein, I.D. (1989) Precursors of colony-forming cells in humans can be distinguished from colony-forming cells by expression of the CD33 and CD34 antigens and light scatter properties. Journal of Experimental Medicine, 169, 1721-1731.
3. Barnett, M.J., Eaves, C.J., Phillips, G.L., Gascoyne, R.D., Hogge, D.E., Horsman, D.E., Humphries, R.K., Klingemann, H-G., Lansdorp, P.M., Nantel, S.H., Reece, D.E., Shepherd, J.D., Spinelli, J.J., Sutherland, H.J. & Eaves, A.C. (1994) Autografting with cultured marrow in chronic myeloid leukemia: results of a pilot study. Blood, 84, 724-732.
4. Barnett, M.J., Eaves, C.J., Phillips, G.L., Kalousek, D.K., Kingemann, H-G., Lansdorp, P.M., Reece, D.E., Shepherd, J.D., Shaw, G.J. & Eaves, A.C. (1989) Successful autografting in chronic myeloid leukaemia after maintenance of marrow in culture. Bone Marrow Transplantion, 4, 345-351.
5. Brandwein, J.M., Dubé, I.D., Laraya, P. & Keating, A. (1992) Maintenance of Philadelphia chromosome positive progenitors in long-term marrow cultures from patients with advanced chronic myeloid leukemia. Leukemia, 6, 556-561.
6. Coulombel, L., Kalousek, D.K., Eaves, C.J., Gupta, C.M. & Eaves, A.C. (1983) Long-term marrow culture reveals chromosomally normal hematopoietic progenitor cells in patients with Philadelphia chromosome-positive chronic myelogenous leukemia. New England Journal of Medicine, 308, 1493-1498.
7. Coutinho, L.H., Gilleece, M.H., De Winter, E.A., Will, A. & Testa, N.G. (1993) Clonal and long-term cultures using human bone marrow. Haematology: a Practical Approach (ed. by N. G. Testa and G. Molineux), pp. 75-106. Oxford University Press.
8. Coutinho, L.H., Testa, N.G., Chang, J., Morgenstern, G., Harrison, C. & Dexter, T.M. (1990) The use of cultured bone marrow cells in autologous transplantation. Bone Marrow Purging and Processing (ed. by S. Gross, A. P. Gee and D. A. Worthington-White), pp. 415-433. A. R. Liss, New York.
9. Dubé. I.D., Eaves, C.J., Kalousek, D.K. & Eaves, A.C. (1981) A method for obtaining high quality chromosome preparations from single haemopoietic colonies on a routine basis. Cancer Genetics and Cytogenetics, 4, 157-168.
10. 1-positive chronic myeloid leukaemia (CML). British Journal of Haematalogy, 56, 633-644.
11. 1-negative progenitors in treated as well as newly diagnosed patients. Blood, 63, 1172-1177.
12. Eaves, A.C., Cashman, J.D., Gaboury, L.A., Kalousek, D.K. & Eaves, C.J. (1986) Unregulated proliferation of primitive chronic myeloid leukemia progenitors in the presence of normal marrow adherent cells. Proceedings of the National Academy of Sciences of the United States of America, 83, 5306-5310.
13. Eaves, C.J., Cashman, J.D., Wolpe, S.D. & Eaves, A.C. (1993) Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1α, an inhibitor of primitive normal hematopoietic cells. Proceedings of National Academy of Sciences of the United States of America, 90, 12015-12019.
14. Gordon, M.Y., Riley, G.P. & Greaves, M.F. (1987) Plastic-adherent progenitor cells in human bone marrow. Experimental Hematology, 15, 772-778.
15. Haut, A., Abbott, W.S., Wintrobe, M.M. & Cartwright, G.E. (1961) Busulphan in the treatment of chronic myelocytic leukemia: the effect of long term intermittent therapy. Blood, 17, 1-19.
16. Hehlmann, R., Heímpel, H., Hasford, J., Kolb, H.J., Pralle, D.K., Hossfeld, D.K., Queisser, W., Loffler, H., Heinze, B., Georgii, A., Wussow, P.V., Bartram, C., Griesshammer, M., Bergmann, L., Essers, U., Falge, C., Hochhaus, A., Queisser, U., Sick, C., Meyer, P., Schmitz, N., Verpoort, K., Einermacher, H., Walther, F., Westerhaussen, M., Kleeberg, U.R., Heilein, A., Käbish, A., Batz., C., Zimmermann, R., Meurer, G., Tichelli, A., Berdel, W.E., Kanz, L., Anger, B., Tigges, F.J., Schmid, L., Brockhaus, W., Zankovich, R., Schlafer, U., Weisserfelsm I., Mainzer, K., Tobler, A., Perker, M., Hohnloser, J., Messener, D., Thiele, J., Buhr, T., Ansari, H., and the German CML Study Group (1993) Randomized comparison of busulphan and hydroxyurea in chronic myelogenous leukemia: prolongation of survival by hydroxyurea. Blood, 82, 398-407.
17. Holyoake, T.L., Freshney, M.G., Sproul, A.M., Richmond, L.J., Alcorn, M.J., Steward, W.P., Fitzsimons, E., Dunlop, D.J., Franklin, I.M. & Pragnell, I.B. (1993) Contrasting effects of rh-MIP-1α and TGF-β1 on chronic myeloid leukemia progenitors in vitro. Stem Cells, 11, 122-128.
18. Kantarjian, H.M., Deisseroth, A., Kurzrock, R., Estrov, Z., & Talpaz, M. (1995) Chronic myelogenous leukemia: a concise update. Blood, 82, 691-703.
19. Kloke, O., Niederle, N., Qiu, J.Y., Wandi, U., Moritz, T., Nagel-Hiemke, M., Hawig, I., Opalka, B., Seeber, S. & Becher, R. (1993) Impact of interferon alpha-induced cytogenetic improvement on survival in chronic myelogenous leukaemia. British Journal of Haematology, 83, 399-403.
20. Kolitz, J.E., Kempin, S.J., Schluger, A., Wong, G.Y., Berman, E., Jhanwar, S., Arlin, Z.A., Gee, T. & Clarkson, B.D. (1992) A phase II pilot trial of high-dose hydroxyurea in chronic myelogenous leukemia. Seminars in Oncology, 19, 27-33.
21. Kuss, B.J., Sage, R.E., Shepherd, K.M., Hardingham, J. & Nicola, M. (1995) High dose hydroxyurea in collection of Philadelphia chromosome-negative stem cells in chronic myeloid leukemia. Leukemia and Lymphoma, 10, 73-78.
22. Molineux, G., Testa, N.G., Massa, G. & Schofield, R. (1985) An analysis of haemopoietic and microenvironmental populations of mouse bone marrow after treatment with busulphan. Biomedical Pharmacotherapy, 40, 215-220.
23. Talpaz, M., Kantarjian, H., Kurzrock, R., Trujillo, J.M. & Gutterman, J.U. (1991) Interferon-alpha produces sustained cytogenetic responses in chronic myelogenous leukemia: Philadelphia chromosome-positive patients. Annals of Internal Medicine, 114, 532-538.
24. The Italian Cooperative Study Group on Chronic Myeloid Leukaemia (1994) Interferon alpha-2α as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. New England Journal of Medicine, 330, 820-825.
25. Udomsakdi, C., Eaves, C.J., Lansdorp, P.M. & Eaves, A.C. (1992a) Phenotypic heterogeneity of primitive leukemic hematopoietic cells in patients with chronic myeloid leukemia. Blood, 80, 2522-2530.
26. Udomsakdi, C., Eaves, C.J., Swolin, B., Reid, D.S., Barnett, M.J. & Eaves, A.C. (1992b) Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level. Proceedings of the National Academy of Sciences of the United States of America, 89, 6192-6196.