Dexamethasone attenuates hypoglycemia in ten day old rats treated with TNF alpha

Research Communications in Molecular Pathology and Pharmacology

Volumn 92, Issue 2, 1996, Pages 149-154

  Battelino, Tadej ^a   Goto, Masakatsu ^a   Zeller, W Patrick ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOSE; GLUCOSE TRANSPORTER; INSULIN; LACTIC ACID; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GLUCONEOGENESIS; HYPOGLYCEMIA; INTRAPERITONEAL DRUG ADMINISTRATION; LACTIC ACIDEMIA; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SEPTIC SHOCK; TISSUE DISTRIBUTION;

ANIMALS; BLOOD GLUCOSE; DEXAMETHASONE; DRUG INTERACTIONS; FEMALE; GLUCOCORTICOIDS; GLUCOSE TRANSPORTER TYPE 1; HYPOGLYCEMIA; INSULIN; LACTATES; LACTIC ACID; MICE; MONOSACCHARIDE TRANSPORT PROTEINS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029975257     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Evans D.A., Jacobs D.O. and Wilmore D.W. (1989) Tumor necrosis factor enhances glucose uptake by peripheral tissues. Am.J.Physiol. 257: R1182-R1189.
2. Girardin E., Gran G.E., Dayer J.M., Roux-Lombard P., and The J5 study group. (1988) Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura. N.Engl.J.Med 319: 397-400.
3. Goto M., Zeller W.P.,and Hurley R.M. (1990) Dexamethasone and indomethacin treatment during endotoxicosis in the suckling rat. Circ Shock 32: 113-122.
4. Goto M, Zeller W.P. and Lichtenberg R.C. (1994) Decreased gluconeogenesis and increased glucose disposal without hyperinsulinemia in 10-day-old rats with endotoxic shock. Metabolism 43: 1248-1254.
5. Gould G.W., and Bell G. (1990). Facilitative glucose transporters: an expanding family. Trend Biochem.Sci. 15: 18-23.
6. 100 septic shock following steroid/antibiotic therapy. J.Surg.Res. 28: 150-170.
7. Kutteh W.H., Rainey W.E., and Carr B.R. (1991) Glucocorticoids inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by human fetal Kupffer cells. J.Clin.Endocr.Metab. 73: 296-301.
8. Leake R.D., Fiser R.H., and Oh W. (1981) Rapid glucose disappearance in infants with infection. Clin.Pediatr. 20: 397-401.
9. McCallum R.E., Scale T.W.,and Stith R.D. (1983) Influence of endotoxin treatment on dexamethasone induction of hepatic phosphoenolpyruvate carboxykinase. Infect. Immun. 39: 213-219.
10. Meszaros K., Lang C.H., Bagby G.J., and Spitzer JJ. (1987) Contribution of different organs to increased glucose consumption after endotoxin administration. J.Biol.Chem. 262: 10965-10970.
11. Postic C., Leturque A., Printz .RL., Maulard P., Loizeau M., Granner D.K., and Girard J. (1994) Development and regulation of glucose transporter and hexokinase expression in rat. Am.J.Physiol. 266, E548-E559.
12. Tracey K.J., Beutler B., Lowry S.F., Merryweather J., Wolfe S., Milsark I.W., Hariri R.J., Fahey T.J., Zentella A., Albert J.D., Shires G.T., and Cerami A. (1986) Shock and tissue injury induced by recombinant human cachectin. Science 1986; 234: 470-474.
13. Tsujimoto M., and Adachi H. (1988) Effects of steroid hormones on the cytotoxic activity of tumor necrosis factor. J.Biochem. 103: 393-395.
14. Vary T.C., Drnevich D., Jurasinski C., and Brennan W.A. Jr.: (1995) Mechanisms regulating skeletal muscle glucose metabolism in sepsis. Shock 3:403-410.
15. Waage A., Halstensen A.,and Espevik T. (1987) Studies on the inhibition of glycogenolysis by D-galactosamine in rat liver hepatocytes. Lancet 14: 355-357.
16. Yeung C.Y. (1970) Hypoglycemia in neonatal sepsis J.Pediatr. 77: 812-817.
17. Zeller W.P., The S.M., Sweet M., Goto M., Gottschalk M.E., Hurley R.H., Filkins J.P., and Hofmann C. (1991) Altered glucose transporter mRNA abundance in a rat model of endotoxic shock. Biochem.Biophys.Res.Commun. 176:535-540.