Effects of dimethylformamide on in vivo fatigue and metabolism in rat skeletal muscle measured by 31p-nmr

Journal of Pharmacological and Toxicological Methods

Volumn 35, Issue 3, 1996, Pages 139-143

  Le Tallec, Nathalie ^a   Lacroix, Pierre ^b   De Certaines, Jacques D ^b   Chagneau, Francis ^b   Levasseur, René ^b   Le Rumeur, Elisabeth ^b  

^a Faculté de Médecine   (France)

^b NONE

Author keywords

31p magnetic resonance spectroscopy; Contraction; Dimethylformamide; Skeletal muscle; Solvent

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; DRUG VEHICLE; INDUSTRIAL TOXIC SUBSTANCE; N,N DIMETHYLFORMAMIDE; PHOSPHATE; SOLVENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PH; CONTROLLED STUDY; ENERGY METABOLISM; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MUSCLE FATIGUE; MUSCLE METABOLISM; MUSCLE TONE; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; RAT; SKELETAL MUSCLE;

ANIMALS; DIMETHYLFORMAMIDE; ENERGY METABOLISM; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MUSCLE CONTRACTION; MUSCLE FATIGUE; MUSCLE, SKELETAL; PHOSPHOCREATINE; PHOSPHORIC ACID ESTERS; PHOSPHORUS; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0029975250     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/1056-8719(96)00024-X     Document Type: Article

References (16)

1. Burges RA, Blackburn KJ, Spilker BA (1969) Effects of Dimethylsulfoxide, Dimethylformamide and Dimethylacetamide on myocardial contractility and enzyme activity. Life Sci 23:1325-1335.
2. Chance B, Leigh JS, McCully K, Nioka S, Clark BJ, Maris JM, Graham T (1986) Control of oxidative metabolism and oxygen delivery in human skeletal muscle: a steady-state analysis of the work/energy cost transfer function. Proc Natl Acad Sci USA 83:9458-9462.
3. 31P-NMR. Muscle & Nerve 16:91-98.
4. de Motta GE, Cordoba F, de Leon M, del Castillo J (1982) Inhibitory action of high Formamide concentrations on Excitation-Contraction coupling in skeletal muscle. J Neurose Res 7:163-178.
5. Fabiato A, Fabiato F (1978) Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiac and skeletal muscle. J Physiol 276:233-255.
6. Gescher A (1993) Metabolism of N,N-Dimethylformamide: key to the understanding of its toxicity. Chem Res Toxicol 6:245-251.
7. Kennedy GL (1986) Biological effects of acetamide, formamide, and their monomethyl and dimethyl derivatives. Crit Rev Toxicol 17: 129-182.
8. Kennedy GL, Sherman H (1986) Acute and subchronic toxicity of Dimethylformamide and Dimethylacetamide following various routes of administration. Drug Chem Toxicol 9(2):147-170.
9. Kushmerick M, Meyer R (1985) Chemical changes in rat leg muscle by phosphorus nuclear magnetic resonance. Am J Physiol 248:C542-C549.
10. Massmann W (1956) Toxicological investigations on Dimethylformamide. Brit J Industr Med 13:51-54.
11. Mathew T, Karunanithy R, Yee MH, Pharm BS, Natarajan PN (1980) Hepatotoxicity of Dimethylformamide at and above the levels used in some Aflatoxin studies. Lab Invest 42(2):257-262.
12. Mraz J, Cross H, Gescher A, Threadgill MD, Flek J (1989) Differences between rodents and humans in the metabolic toxification of N,N-Dimethylformamide. Toxicol Appl Pharmacol 98:507-516.
13. Potter HP (1973) Dimethylformamide-induced abdominal pain and liver injury. Arch Envir Health 27:340-341.
14. Scailteur V, Lauwerys RR (1987) Dimethylformamide (DMF) hepatotoxicity. Toxicology 43:231-238.
15. Spilker B (1970) Inotropic actions of dipolar aprotic solvents. J Pharmacol Exp Ther 175(2):361-367.
16. Wilkie DR (1986) Muscular fatigue: effects of hydrogen ions and inorganic phosphate. Fed Proc 45:2921-2923.