Differential effects of gonadectomy on the thymocyte phenotypic profile in male and female rats

Pharmacology Biochemistry and Behavior

Volumn 54, Issue 1, 1996, Pages 269-276

  Leposavic G ^a   Karapetrovic B ^a   Obradovic S ^a   Vidic Dankovic B ^a   Kosec, D ^a  

^a Immunology Research Center Belgrade   (Yugoslavia)

Author keywords

sex steroids; sexual dimorphism; sexual maturation; thymic cellularity; thymocyte phenotypic characteristics

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MEMBRANE ANTIGEN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GONADECTOMY; LYMPHOCYTE SUBPOPULATION; MALE; NONHUMAN; ORCHIECTOMY; ORGAN WEIGHT; OVARIECTOMY; PHENOTYPE; PREPUBERTY; PRIORITY JOURNAL; PUBERTY; RAT; SEX DIFFERENCE; SEXUAL MATURATION; THYMOCYTE; THYMUS;

EID: 0029975104     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)02165-5     Document Type: Conference Paper

References (55)

1. Aarow, S.; Fraser, P. A.; Jackson, J. M.; Larson, M.; Glass, J. Sex ratio and sibship size in juvenile rheumatoid arthritis. Arthritis Rheum. 28:753-759; 1985.
2. Aboudkhil, S.; Bureau, J. P.; Garrelly, L.; Vago, P. Effects of castration, depo-testosterone and cyproterone acetate on lymphocyte T subsets in mouse thymus and spleen. Scand. J. Immunol. 34:647-653; 1991.
3. Anderson, S. J.; Perlmutter, R. M. A signaling pathway governing early thymocyte maturation. Immunol. Today 16:99-105; 1995.
4. Ansar Ahmed, S.; Penhale, W. J.; Talal, N. Sex hormones, immune responses and autoimmune diseases. Mechanisms of sex hormone action. Am. J. Pathol. 121:531-551; 1985.
5. Arrenbrecht, S.; Sorkin, E. Growth hormone-induced T-cell differentiation. Eur. J. Immunol. 3:601-608; 1973.
6. Barr, I. G.; Khalid, B. A. K.; Pearce, P.; Toh, B. H.; Bartlett, R.; Scollay, G.; Funder, J. W. Dihydrotestosterone and estradiol deplete corticosensitive thymocytes lacking in receptors for these hormones. J. Immunol. 128:2825-2832; 1982.
7. Blazovec, A. A.; Orsini, M. W. Ontogenic aspects of sexual dimorphism and the primary immune response to sheep erythrocytes in hamsters from puberty to senescence. Int. Arch. Allergy Appl. Immunol. 50:55-63; 1976.
8. Butterworth, M.; McClellan, B.; Allansmith, M. Influence of sex on immunoglobulin levels. Nature 214:1224-1225; 1967.
9. Cordier, A. C. Ultrastructure of the thymus in "nude" mice. J. Ultrastruct. Res. 47:26-40; 1974.
10. Crispe, I. N.; Shimonkewitz, R. P.; Hussman, L. A.; Kimura, J.; Allson, J. P. Expression of T-cell antigen receptor β-chain on subsets of mouse thymocytes. Analysis of three color flow cytometry. J. Immunol. 139:3585-3588; 1987.
11. Eden, S. Age and sex-related differences in episodic growth hormone secretion in the rat. Endocrinology 105:555-563; 1979.
12. Evagelaton, M.; Webster, A. D. B.; Farrant, J. Effects of 17β-estradiol on function of lymphocytes from normal donors and patients with common variable immunodeficiency (CVID). Clin. Exp. Immunol. 98:203-209; 1994.
13. Felten, D.; Felten, S.; Bellinger, D.; Carlson, S.; Ackerman, K. D.; Madden, K. S.; Olschowka, J. A.; Livant, S. Noradrenergic sympathetic neural interactions with the immune system: Structure and function. Immunol. Rev. 100:225-243; 1987.
14. Fujii-Hanamoto, H.; Seiki, K.; Sakabe, K.; Ogawa, H. Progestin receptor in the thymus of ovariectomized immature rats. J. Endocrinol. 107:223-229; 1985.
15. Fujii-Hanamoto, H.; Grossman, C. J.; Roselle, G. A.; Mendenhall, C. L.; Seiki, K. Nuclear progestin receptor in rat thymic tissue. Thymus 15:31-45; 1990.
16. Gagnerault, M. C.; Touraine, P.; Savino, W.; Kelly, P. A.; Dardenne, M. Expression of prolactin receptor in murine lymphoid cells in normal and autoimmune situations. J. Immunol. 150: 5673-5681; 1993.
17. Giguere, V.; Meunier, H.; Veilleux, R.; Labrie, F. Direct effect of sex steroids on prolactin release at the anterior pituitary level: Interactions with dopamine, thyrotropin-releasing hormone, and isobutyl-methylxanthine. Endocrinology 111:857-864; 1982.
18. Graff, R. J.; Lappe, M. A.; Snell, G. D. The influence of the gonads and adrenal glands on the immune response to skin grafts. Transplantation 7:105-111; 1969.
19. Grossman, C. J.; Nathan, P.; Taylor, B. B.; Sholiton, L. J. Rat thymic dihydrotestosterone receptor: Preparation, location and physicochemical properties. Steroids 34:539-553; 1979.
20. Grossman, C. J.; Sholiton, L. J.; Blaha, G. C.; Nathan, P. Rat thymic estrogen receptor II. Physiological properties. J. Steroid. Biochem. 11:1241-1246; 1979.
21. Grossman, C. J. Interactions between the gonadal steroids and the immune system. Science 227:257-261; 1985.
22. Grossman, C. J. Are there underlying immune-neuroendocrine interactions responsible for immunological sexual dimorphism. Prog. Neuroendocrimmunol. 3:75-82; 1990.
23. Gulino, A.; Screpanti, I.; Pasqualini, J. R. Estrogen and antiestrogen effects on different lymphoid cell populations in the developing fetal thymocytes of guinea pig. Endocrinology 113:1754-1761; 1983.
24. Gulino, A.; Screpanti, I.; Torrisi, M. R.; Frati, L. Estrogen receptors and estrogen sensitivity of fetal thymocytes are restricted to blast lymphoid cells. Endocrinology 117:47-54; 1985.
25. Homo-Delarche, F.; Fitzpatrick, F.; Christeff, N.; Nunez, E. A.; Bach, J. F.; Dardenne, M. Sex steroids, glucocorticoids, stress and autoimmunity. J. Steroid. Biochem. 10:619-627; 1991.
26. Inman, R. D. Immunologic sex differences and the female predominance in systemic lupus erythematosus. Arthritis Rheum. 21: 849-852; 1978.
27. Kawashima, I.; Sakabe, K.; Seiki, K.; Fujii-Hanamoto, H.; Akatsuka, A.; Tsukamoto, H. Localization of sex steroid receptor cells, with special reference to thymulin (FTS)-producing cells in female rat thymus. Thymus 18:79-93; 1991.
28. Kendall, M. D. Functional anatomy of the thymic microenvironment. J. Anat. 177:1-29; 1991.
29. Khosla, S.; Ovalle, W. K. Morphology and distribution of cystic cavities in the normal murine thymus. Cell. Tissue Res. 246:531-542; 1986.
30. Kiess, W.; Holtmann, H.; Butenandt, O.; Eife, R. Modulation of lymphoproliferation by human growth hormone. Eur. J. Pediatr. 140:47-53; 1983.
31. Kovacs, W. J.; Olsen, N. J. Androgen receptors in human thymocytes. J. Immunol. 139:490-493; 1987.
32. Leposavić, G.; Mićić, M. Testosterone binding sites in the rat thymus during late embryonal and postnatal period. Thymus 20: 77-89; 1992.
33. Leposavić, G.; Karapetrović, B.; Budeč, M.; Kosec, D. Sex differences in the phenotypic characteristics of the rat thymocytes. Acta Vet. 45:215-220; 1995.
34. Leposavić, G.; Karapetrovi, B.; Mićić, M.; Kosec, D. Prepubertal castration alters the phenotypic profile of adult rat thymocytes. Neuroimmunomodulation 2:100-107; 1995.
35. 2-adrenergic receptor in the thymus and presence of sexual dimorphism during ontogeny. Prog. Neuroendocrimmunol. 3:103-115; 1990.
36. Martin, A.; Alonso, L.; Gomez del Moral, M.; Zapata, A. G. Morphometrical changes in the rat thymic lymphoid cells after treatment with two different doses of estradiol benzoate. Histol. Histopathol. 9:281-286; 1994.
37. Matsumoto, K.; Yoshikai, Y.; Moroi, Y.; Asano, T.; Ando, T.; Nomoto, K. Two differential pathways from double-negative to double-positive thymocytes. Immunology 72:20-26; 1991.
38. Montgomery, D. W.; Shen, G. K.; Ulrich, E. D.; Steiner, L. L.; Parrish, P. R.; Zukoski, C. F. Human thymocytes express a prolactin-like messenger ribonucleic acid and synthesize bioactive prolactin-like proteins. Endocrinology 131:3019-3026; 1992.
39. Nikolić-Žugić, J. Phenotypic and functional stages in theintrathymic development of αβ T-cells. Immunol. Today 12:65-70; 1991.
40. Olsen, N. J.; Watson, M. B.; Henderson, G. S.; Kovacs, W. J. Androgen deprivation induces phenotypic and functional changes in the thymus of adult male mice. Endocrinology 129:2471-2476; 1991.
41. Olsen, N. J.; Watson, M. B.; Kovacs, W. J. Studies of immunological function in mice with defective androgen action. Distinction between alterations in immune function due to hormonal insensitivity and alterations due to other genetic factors. Immunology 73:52-57; 1991.
42. Olsen, N. J.; Zhou, P.; Ong, H.; Kovacs, W. J. Testosterone induces expression of transforming growth factor beta in the murine thymus. J. Steroid. Biochem. Mol. Biol. 45:327-332; 1993.
43. Olsen, N. J.; Viselli, S. M.; Shults, K.; Stelzer, G.; Kovacs, W. J. Induction of immature thymocyte proliferation by castration of normal male mice. Endocrinology 134:107-113; 1994.
44. Palmer, D. B.; Hayday, A.; Owen, M. J. Is TCR β expression an essential event in early thymocyte development? Immunol. Today 9:460-461; 1993.
45. Pearce, P.; Khalid, B. A. K.; Funder, J. W. Androgens and thethymus. Endocrinology 109:1073-1079; 1981.
46. Penit, C.; Vasseur, F. Sequential events in thymocyte differentiation and thymus regeneration revealed by a combination of bromodeoxyuridine DNA labeling and antimitotic drug treatment. J. Immunol. 140:3315-3327; 1988.
47. Reinherz, E. L.; Schlossman, S. F. The differentiation and function of human T-lymphocytes. Cell 19:821-827; 1980.
48. Roehm, N.; Herron, L.; Cambien, J.; Di Guislo, D.; Masicins, K.; Kappler, J.; Marrack, P. The major histocompatibility complex-restricted antigen receptor on T-cells: Distribution on thymus and peripheral T-cells. Cell 38:577-383; 1984.
49. Roubinian, J. R.; Talal, N.; Siiteri, P. R.; Sadakin, J. A. Sex hormones modulation of autoimmunity in NZB/NZW mice. Arthritis Rheum. 22:1162-1169; 1979.
50. Sakabe, K.; Kawashima, I.; Urano, R.; Seiki, K.; Itoh, T. Effects of sex steroids on the proliferation of thymic epithelial cells in a culture model: A role of protein kinase C. Immunol. Cell. Biol. 72:193-199; 1994.
51. Screpanti, I.; Morrone, S.; Meco, D.; Santoni, A.; Gulino, A.; Paolini, R.; Crisanti, A.; Mathieson, B. J.; Frati, L. Steroid sensitivity of thymocyte subpopulations during intrathymic differentiation. J. Immunol. 142:3378-3383; 1989.
52. Stumpf, W. E.; Madhabananda, S. Autoradiographic localization of estrogen, androgen, progestin and glucocorticoid receptors in "target" tissues and "non target" tissues. In: Pasqualini, J. R., ed. Receptor and mechanisms of action of steroid hormones. New York: Marcel Dekker Inc.; 1976:41-48.
53. Thompson, E. B. Apoptosis and steroid hormones. Mol. Endocrinol. 8:665-673; 1994.
54. Utsuyama, M.; Hirokawa, K. Hypertrophy of the thymus andrestoration of immune functions in mice and rats by gonadectomy. Mech. Ageing Dev. 47:175-185; 1989.
55. Vacchio, M.; Papandopoulos, V.; Ashwell, J. D. Steroid production in the thymus: Implications for thymocyte selection. J. Exp. Med. 179:1835-1846; 1994.