Synthesis of highly functionalized γ-lactam derivatives for use as conformational constraints in peptides

Tetrahedron Letters

Volumn 37, Issue 14, 1996, Pages 2471-2474

  Martín Martínez, Mercedes ^a   García López, Ma Teresa ^a   Herranz, Rosario ^a   González Muñiz, Rosario ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA LACTAM DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0029975052     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00296-1     Document Type: Article

References (21)

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16. 7 position of these 7-benzyl derivatives was established by means of n.O.e. experiments.
17. 4: C, 66.26; H, 7.02; N, 8.13. Found: C, 65.97; H, 7.21; N, 8.06.
18. 3 in MeOH (7 mL) at room temperature for the time indicated in Table 2. After evaporation of the solvents, the resulting residue was purified on a silica gel column using EtOAc-hexane (1:1) as eluent.
19. 5: C, 63.81; H, 7.50; N, 7.44. Found: C, 64.01; H, 7.18; N, 7.21.
20. Altman, J.; Ben-Ishai, D. Tetrahedron: Asymmetry 1993, 4, 91-100.
21. Schmidt, U.; Rield, B.; Haas, G.; Griesser, H.; Vetter, A.; Weinbrenner, S. Synthesis 1993, 216-220.