Accumulation of orally given cadmium in Long-Evans Cinnamon (LEC) rats with an inherently abnormal copper metabolism

Toxicology

Volumn 108, Issue 1-2, 1996, Pages 1-7

  Sugawara, Naoki ^a   Lai, Yu Rong ^a   Sugawara, Chieko ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Biliary excretion; Cadmium; Copper; Long Evans Cinnamon rat; Metallothionein

Indexed keywords

CADMIUM; METALLOTHIONEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; BIOACCUMULATION; CONTROLLED STUDY; COPPER METABOLISM; FEMALE; KIDNEY; LIVER; NONHUMAN; PRIORITY JOURNAL; RAT; WILSON DISEASE;

ANIMALIA; CINNAMOMUM VERUM; TRIXIS;

EID: 0029975042     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(95)03264-G     Document Type: Article

References (24)

1. Bartsch, S.L., Klein, D. and Summer, K.H. (1990) The Cd-chelex assay: a new sensitive method to determine metallothionein containing zinc and cadmium. Arch. Toxicol. 64, 177-180.
2. Bremner, I. and Campbell, J.K. (1980) The influence of dietary copper intake on the toxicity of cadmium. Ann. N. Y. Acad. Sci. 355, 319-332.
3. Bull, P.C., Thomas, G.R., Rommens, J.M., Forbes, J.R. and Cox, D.W. (1993) The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nat. Genet. 5, 327-337.
4. Cherian, M.G., Goyer, R.A. and Delaquerriere-Richardson, L. (1976) Cadmium-metallothionein-induced nephropathy. Toxicol. Appl. Pharmacol. 38, 399-408.
5. Iron, R.D. and Smith, C. (1976) Prevention by copper of cadmium sequestration by metallothionein in liver. Chem.-Biol. Interact. 15, 289-294.
6. Klaassen, C.D. (1978) Effect of metallothionein on hepatic disposition of metals. Am. J. Physiol. 234, E47-E53.
7. Klaassen, C.D. and Kotsonis, F.N. (1977) Biliary excretion of cadmium in the rat, rabbit and dog. Toxicol. Appl. Pharmacol. 41, 101-112.
8. Li, Y., Togashi, Y., Sato, S., Emoto, T., Kang, J.-H., Takeichi, N., Kobayashi, H., Kojima, Y., Une, Y. and Uchino, J. (1991) Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. J. Clin. Invest. 87, 1858-1861.
9. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
10. Mikalsen, A., Daae, H.L., Alexander, J. and Andersen, R.A. (1989) Is metallothionein involved in deposition of cadmium? Gen. Pharmacol. 20, 11-15.
11. Nordberg, G.F., Goyer, R. and Nordberg, M. (1975) Comparative toxicity of cadmium-metallothionein and cadmium chloride on mouse kidney. Arch. Pathol. 99, 192-197.
12. Nucifora, G., Chu, L., Misra, T.K. and Silver, S. (1989) Cadmium resistance from Staphylococcus aureus plasmid pI258 cadA gene results from a cadmium-efflux ATPase. Proc. Natl. Acad. Sci. USA 86, 3544-3548.
13. Ono, T., Takada, S. and Yoshida, M.C. (1994) The WD gene for Wilson's disease links to the hepatitis of LEC rats. Jpn. J. Cancer Res. 85, 771-774.
14. Sasaki, N., Hayashizaki, Y., Muramatsu, M., Matsuda, Y., Ando, Y., Kuramoto, T., Serikawa, T., Azuma, T., Naito, A., Agui, T., Yamashita T., Miyosgi, I., Takeichi, N. and Kasai, N. (1994) The gene responsible for LEC hepatitis, located on rat chromo some 16, is the homolog to the human Wilson disease gene. Biochem. Biophys. Res. Commun. 202, 512-518.
15. Schosinsky, K.H., Lehman, H.D. and Beeler, M.F. (1974) Measurement of ceruloplasmin from its oxidase activity in serum by use of O-dianisidine dihydrochloride. Clin. Chem. 20, 1556-1563.
16. Sugawara, N. and Sugawara, C. (1991a) Absorption of cadmium-metallothionein from the gastrointestinal tract. In. Metallothionein in Biology and Medicine. edits. Klaassen, C.D. and Suzuki, K.T. CRC press pp. 165-170.
17. Sugawara, N., Sugawara, C., Sato, M., Katakura, M., Takahashi, M. and Mori, M. (1991b) Copper metabolism in LEC rats aged 30 and 80 days old: induction of Cu-methallothionein and status of zinc and iron. Res. Commun. Chem. Pathol. Pharmacol. 72, 353-362.
18. Sugawara, N., Li, D., Sugawara, C. and Miyake, H. (1993a) Decrease in biliary excretion of copper in Long-Evans Cinnamon (LEC) rats causing spontaneous hepatitis due to a gross accumulation of hepatic copper. Res. Commun. Chem. Pathol. Pharmacol. 81, 45-52.
19. Sugawara, N., Sugawara, C., Sato, M. and Mori, M. (1993b) Copper metabolism at two satges in the onset of spontaneous hepatitis in new mutant Long-Evans Cinnamon (LEC) rats: induction of hepatic copper-metallothionein and its leakage from hepatocytes. J. Trace Elem. Exp. Med. 6, 15-21.
20. Sugawara, N., Li, D. and Sugawara, C. (1994) Biliary excretion of exogenous cadmium and maganese in Long-Evans Cinnamon (LEC) rats characterized by an inherently gross amount of copper-metallothionein in the liver. Arch. Toxicol. 68, 520-523.
21. 109Cd-labeled metallothionein in rats. Toxicol. Appl. Pharmacol. 33, 258-266.
22. Waalkes, M.P., Harvey, M.J. and Klaassen, C.D. (1984) Relative in vitro affinity of hepatic metallothionein for metals. Toxicol. Lett. 20, 33-39.
23. Yamada, T., Kim J-K., Suzuki, Y., Agui, T., Matsumoto, K. (1993) Reduced efficiency of copper transport from cytosolic to non-cytosolic fractions in LEC mutant rat. Res. Commun. Chem. Pathol. Pharmacol. 81, 234-246.
24. Yamaguchi, Y., Heiny, M.E., Shimizu, N., Aoki, T. and Gitlin, J.D. (1994) Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat. Biochem. J. 301, 1-4.