Dissociation of p75 receptors and nerve growth factor neurotrophic effects: Lack of p75 immunoreactivity in striatum following physical trauma, excitotoxicity and NGF administration

Restorative Neurology and Neuroscience

Volumn 10, Issue 1, 1996, Pages 49-59

  Bartus, Raymond T ^a,c   Dean, Reginald L ^a   Abelleira, Susan ^a   Charles, Vinod ^b   Kordower, Jeffrey H ^b  

^a ALKERMES INC   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Injury; Nerve growth factor; p75; Receptor regulation; Trophic response

Indexed keywords

CHOLINE ACETYLTRANSFERASE; NERVE GROWTH FACTOR;

ANIMAL EXPERIMENT; ARTICLE; BRAIN INJURY; CORPUS STRIATUM; FEMALE; IMMUNOREACTIVITY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029974984     PISSN: 09226028     EISSN: None     Source Type: Journal    
DOI: 10.3233/rnn-1996-10107     Document Type: Article

References (40)

1. Altar, C.A., Nerve growth factor and the neostriatum, Prog. Neuro-Psychopharmacol. Biol. Psychiat., 15 (1991) 157-169.
2. Altar, C.A., Armanini, M., Dugich-Djordjevic, D., Bennett, G.L., Williams, R., Feinglass, S., Anicetti, V., Sinicropi, D. and Bahit, C., Recovery of cholinergic phenotype in the injured rat neostriatum: Roles for endogenous and exogenous nerve growth factor, J. Neurochem., (1992) 2167-2177.
3. LNTR reduces NGF binding to TrkA on PC12 cells, Neuron, 13 (1994) 203-215.
4. Benedetti, M., Levi, A. and Chao, M.S., Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness, Proc. Natl. Acad. Sci. USA, 90 (1993) 7859-7863.
5. Bothwell, M., Keeping track of neurotrophin receptors, Cell, 65 (1991) 915-918.
6. Chao, M.V., Neurotrophin receptors: A window into neuronal differentiation, Neuron, 9 (1992) 583-593.
7. Feinstein, D. and Larhammer, D., Identification of a conserved protein motif in a group of growth factor receptors, FEBS Lett, 272 (1990) 7-11.
8. Friden, P.M., Walus, L.R., Watson P., Doctrow, S.R., Kozarich, J.W., Backman, C., Bergman, U., Hoffer, B., Bloom, F. and Granholm, A.C., Blood-brain barrier penetration and in vivo activity of an NGF conjugate, Science, 259 (1993) 373-377.
9. Friden, P.M., Walus, L.R., Musso, G.F., Taylor, M.A., Malfroy, B. and Starzyk, R.M., Anti-transferrin receptor antibody and antibody-drug conjugate cross blood-brain barrier, Proc. Natl. Acad. Sci USA, 88 (1991) 4771-4775.
10. Frim, D.M., Uhler, T.A., Short, M.P., Ezzedine, Z.D., Klagsbrun, M., Breakefield, X.O. and Isacson, O., Striatal degeneration induced by mitochondrial blockade is prevented by biologically delivered NGF, J. Neurosci. Res., 35 (1993) 452-458.
11. Frim, D.M., Yee, W.M. and Isacson, O., NGF reduces striatal excitotoxic neuronal loss without affecting concurrent neuronal stress, NeuroReport, 4 (1993) 655-658.
12. Gage, F.H., Batchelor, P., Chen, K.S., Chin, C., Higgins, G.A., Koh, S., Deputy, S., Rosenberg, M.B., Fischer, W. and Bjorklund, A., NGF receptor reexpression and NGF-mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum, Neuron, 2 (1989) 1177-1184.
13. Hantzopoulos, P.A., Suri, C., Glass, D.J., Goldfarb, M.P. and Yancopoulos, G.D., The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins, Neuron, 13 (1994) 187-201.
14. Hempstead, B.L., Martin-Zanca, D., Kaplan, D.R., Parada, L.R. and Chao, M.V., High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor, Nature, 350 (1989) 678-683.
15. Hempstead, B.L., Schleifer, L.S. and Chao, M.V., Expression of functional nerve growth factor receptors after gene transfer, Science, 243 (1989) 373-375.
16. Higgins, G.A., Koh, S., Chen, K.S. and Gage, F.H., NGF induction of NGF receptor gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat, Neuron, 3 (1989) 247-56.
17. Holtzman, D.M., Li, Y., Parada, L.F., Kinsman, S., Chen, C-K., Valleta, J.S., Zhou, J., Long, J.B. and Mobley, W.C., p140trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF, Neuron, 9 (1992) 465-478.
18. Ibanez, C.F., Ebendal, T., Barbany, G., Murray-Rust, J., Blundell, T.L. and Persson, H., Similarities and differences in the way neurotrophins interact with the trk receptors in neuronal and nonneuronal cells, Cell, 69 (1992) 329-341.
19. Ip, N., Ibanez, C., Nye, S. et al., Mammalian neurotrophin-4: Structure, chromosomal localization, tissue distribution, and receptor specificity, Proc. Natl. Acad. Sci. USA, 89 (1992) 3060-3064.
20. Jing, S., Tapley, P. and Barbacid, M., Nerve growth factor mediates signal transduction through trk homodimer receptors, Neuron, 9 (1992) 1067-1079.
21. Johnson, E.M., Taniuchi, M., Clark, H.B., Springer, J.E., Koh, S., Tayrien, M.W. and Loy, R., Demonstration of the retrograde transport of NGF receptor in the peripheral and central nervous system, J. Neurosci., 7 (1987) 923-929.
22. Kordower, J.H. and Mufson, E.J., NGF receptor-immunoreactivity in the developing human basal ganglia, J. Comp. Neurol., 327 (1993) 359-374
23. Kordower, J.H., Chen, E.-Y., Sladek, J.R. Jr. and Mufson, E.J., Trk-immunoreactivity in the monkey central nervous system I: Forebrain, J. Comp. Neurol., 349 (1994) 20-35.
24. Kordower, J.H., Charles, V., Baryer, R., Bartus, R.T., Putney, S., Walus, L.R. and Friden, P.M., Intravenous administration of a transferrin receptor antibody-nerve growth factor conjugate prevents the degeneration of cholinergic striatal neurons in a model of Huntington disease, Proc. Natl. Acad. Sci USA, 91 (1994) 9077-9080.
25. Kordower, J.H., Bartus, R.T., Bothwell, M., Schatteman, G. and Gash, D.M., Nerve growth factor receptor immunoreactivity in the nonhuman primate (Cebus apella): Distribution, morphology, and colocalization with cholinergic enzymes, J. Comp. Neurol., 277 (1988) 465-486.
26. Mufson, E.J., Higgins, G.A. and Kordower, J.H., Nerve growth factor receptor-immunoreactivity in the new world monkey (Cebus apella) and human cerebellum, J. Comp. Neurol., 308 (1991) 555-575.
27. Ohmichi, M., Decker, S. and Saltiel, A.R., Nerve growth factor induces the association of 130 Kd phosphoprotein with its receptor in PC12 pheochromocytoma cells, Cell Reg., 2 (1991) 691-697.
28. Parada, L.F., Tsoulfas, P., Tessarollo, L., Blair, J., Reid, S.W. and Soppet, D., The trk family of tyrosine kinases-receptors for NGF-related neurotrophins, Cold Spring Harb. Symp. Quant. Biol., 47 (1992) 43-51.
29. Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, Academic Press (1986).
30. Pioro, E.P. and Cuello, A.C., Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effects of colchicine and correlation with the cholinergic system - I. Forebrain, Neuroscience, 34 (1990) 54-87.
31. Rabizadeh, S., Oh, J., Zhong, L., Yang, J., Bitler, C.M., Butcher, L.L., Bredesen, D.E.,. Induction of apoptosis by the low-affinity NGF receptor, Science, 261 (1993) 345-348.
32. Raivich, G. and Kreutzberg, G.W., The localization and distribution of high affinity βNGF binding sites in the central nervous system in the adult rat. A light microscopic autoradiographic study using (125-1) βNGF, Neuroscience, 20 (1987) 23-36.
33. Richardson, P.M., Vergeissa, V.M.K. and Riopelle, R.J., Distribution of neuronal receptor for nerve growth factor in the rat, J. Neurosci., 6 (1986) 2312-2321.
34. Rodriguez-Tebar, A., Dechant, G., and Barde, Y.-A., Binding of brain-derived neurotrophic factor to the nerve growth factor receptor, Neuron, 4 (1990) 487-492.
35. Schumacher, J.M., Short, M.P., Hyman, B.T., Breakefield, X.O. and Isacson, O., Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids, Neuroscience, 45 (1991) 561-570.
36. Sobreviela, T., Clary, D.O., Reichardt, L.F., Brandabur, M.M., Kordower, J.H., and Mufson, E.J., TrkA immunoreactive profiles in the central nervous system: Colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin, J. Comp. Neurol., 350 (1994) 587-611.
37. Steininger, T.L., Wainer, B.H., Klein, R., Barbacid, M. and Palfrey, H.C., High affinity nerve growth factor receptor (trk) immunoreactivity is localized in cholinergic neurons of the basal forebrain and striatum in the adult rat, Brain Res., 612 (1993) 330-335.
38. Vahlsing, H.L., Varon, S., Hagg, T., Fass-Holmes, B., Dekker, A., Manley, M. and Manthorpe, M., An improved device for continuous intraventricular infusions prevents the introduction of pump-derived toxins and increases the effectiveness of NGF treatments, Exp. Neurol., 105 (1989) 233-243.
39. Weskamp, G., and Reichardt, L.F., Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors, Neuron, 6 (1991) 649-663.
40. Yan, Q. and Johnson Jr., E.M., An immunohistochemical study of the nerve growth factor receptor in developing rats, J. Neurosci., 8 (1988) 3481-3498.