Experimental models of chronic lower extremity arterial occlusive disease: Lessons for drug development

Vascular Medicine

Volumn 1, Issue 1, 1996, Pages 43-49

  Nicholson, C D ^a  

^a NV ORGANON   (Netherlands)

Author keywords

animal models; blood flow; muscle metabolism; oxygen tension; peripheral vascular disease; physical training

Indexed keywords

ANIMAL MODEL; ATHEROSCLEROSIS; CONFERENCE PAPER; INTERMITTENT CLAUDICATION; LIMB ISCHEMIA; NONHUMAN; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; RAT; TRAINING; AEROBIC METABOLISM; ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; BLOOD RHEOLOGY; CHRONIC LOWER EXTREMITY ARTERIAL OCCLUSIVE DISEASE; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFICACY; EXERCISE; FEMORAL ARTERY; GANGRENE; GASTROCNEMIUS MUSCLE; HINDLIMB; PERIPHERAL OCCLUSIVE ARTERY DISEASE; SKELETAL MUSCLE; SMOKING CESSATION;

ANTICOAGULANT AGENT; CALCIUM ANTAGONIST; POTASSIUM CHANNEL; VASODILATOR AGENT;

EID: 0029974604     PISSN: 1358863X     EISSN: None     Source Type: Journal    
DOI: 10.1177/1358863X9600100108     Document Type: Conference Paper

References (58)

1. Dormandy JA, Murray GD. The fate of the claudicant - a prospective study of 1969 claudicants. Eur J Vasc Surg 1991; 5: 131-33.
2. Bell PRF. Peripheral arterial disease. Haemost Thromb 1994; 2: 1275-90.
3. Verhaeghe R, Bounameaux H. Peripheral arterial occlusion: thromboembolism and antithrombotic therapy. In: Fuster V, Verstraete M, eds. Thrombosis in cardiovascular disorders. Philadelphia, PA: Harcourt Brace, 1992.
4. Radack K, Wyderski RJ. Conservative management of intermittent claudication. Am Intern Med 1990; 113: 135-46.
5. Creager MA. Can claudication be treated medically? J Vasc Med Biol 1989; 1: 269-70.
6. Larsen OA, Lassen NA. Effect of daily muscular exercise in patients with intermittent claudication. Lancet 1996; ii: 1093-96.
7. Popendiker K, Boksay J, Bollman V. Zur Pharmakologie des neuen peripheren Gefässdilatators 3,7-Dimethyl-1-(5-oxohexyl)-xanthin. Arzneimittelforschung 1971; 21: 1160-71.
8. Muller R. Hemorrheology and peripheral vascular disease - a new therapeutic approach. J Med 1981; 12: 209-36.
9. Jukna JJ, Nicholson CD. The effect of denbufylline on the viscosity of rat whole blood and on the deformability (filterability) of rat blood cell suspensions. Naunyn-Schmiederbergs Arch Pharmacol 1987; 335: 445-48.
10. PACK Claudication Substudy Investigators. Randomized placebo-controlled, double-blind trial of ketanserin in claudicants. Circulation 1989; 80: 1544-48.
11. Belkin M, Wright JG, Hobson RW. Iloprost infusion decreases skeletal muscle ischemia-reperfusion injury. J Vasc Surg 1990; 11: 77-83.
12. Blebea J, Cambria RA, Defouw D, Feinberg RN, Hobson II RW, Duran WN. Iloprost attenuates the increased permeability in skeletal muscle after ischemia and reperfusion. The value and limitation of iloprost infusion in decreasing skeletal muscle necrosis. J Vasc Surg 1990; 12: 657-66.
13. Mohan C, Marini C, Gennaro M, Ascer E. The value and limitation of iloprost infusion in decreasing skeletal muscle necrosis. J Vasc Surg 1992; 16: 268-73.
14. 124 clearance. J Clin Invest 1964; 43: 1805-12.
15. 2 as guidelines in experimental and clinical drug evaluation. Angiology 1981; 32: 686-98.
16. O'Donnell TF Jr, Clowes GHA, Browse NL, Ryan NT, Blackburn GL. A metabolic approach to the evaluation of peripheral vascular disease. Surg Gynecol obstet 1977; 144: 51-57.
17. Pernow B, Saltin B, Wharen J, Cronestrand R, Ekeström S. Leg blood flow and muscle metabolism in occlusive arterial disease of the leg before and after reconstructive surgery. Clin Sci 1975; 49: 265-75.
18. + channels in cardiovascular medicine. From basic science to clinical practice. Berlin: Springer-Verlag, 1993: 305-19.
19. Angersbach D, Jukna JJ, Nicholson CD, Ochlich P, Wilke R. The effect of acute and chronic femoral artery ligation on rat calf muscle oxygen tension, blood flow, metabolism and function. Int J Microcirc Clin Exp 1987; 7: 15-30.
20. Mathien GM, Terjung RL. Influence of training following bilateral stenosis of the femoral artery in rats. Am Physiol Soc 1986; 250: H1050-H1059.
21. Mathien GM, Terjung RL. Muscle blood flow in trained rats with peripheral arterial insufficiency. Am Physiol Soc 1990; 258: H759-H765.
22. Corsico N, Nardone A, Lucreziotti MR et al. Effect of propionyl-1-carnitine in a rat model of peripheral arteriopathy: a functional, histologic, and NMR spectroscopic study. Cardiovasc Drugs Ther 1993; 7: 241-51.
23. Schoop W. Theoretische Grundlagen der Trainingstherapie bei claudicatio intermittens. Vasa 1973; 2: 169-71.
24. Zetterquist S. The effect of active training on the nutritive blood flow in exercise ischemic legs. Scand J Clin Lab Invest 1970; 25: 101-11.
25. Pernow B. Metabolic aspects of reconstructive surgery and physical training in intermittent claudication. In: Carlson LA, Paoletti R, Simoni CR, Weber C, eds. IV. International conference on atherosclerosis. New York: Raven Press, 1978: 387-91.
26. Nicholson CD, Angersbach D, Wilke R. The effect of physical training on rat calf muscle, oxygen tension, blood flow, metabolism and function in an animal model of chronic occlusive peripheral vascular disease. Int J Sports Med 1992; 13: 60-64.
27. Lorentsen E, Landmark K. The acute effects of nifedipine on calf and forefoot blood flow in patients with peripheral arterial insufficiency. Angiology 1983; 34: 46-52.
28. Lowe GD. Vasodilators: minoxidil and drugs used in peripheral vascular and cerebral disorders. Br Med J 1983; 286: 1262-64.
29. Strandness DE Jr. Ineffectiveness of isoxuprine on intermittent claudication. JAMA 1970; 213: 86-88.
30. 2+ antagonists or hydralazine, in an animal model of occlusive arterial disease. Naunyn Schmiederbergs Arch Pharmacol 1988; 337: 341-46.
31. 31P-NMR spectroscopy. J Vasc Med Biol 1992; 4: 14-22.
32. 2-Electroden. Pflügers Arch 1966; 291: 82-86.
33. Lund N, Ödman S, Lewis DH. Skeletal muscle oxygen pressure fields in rats, a study of the normal state and the effects of local anaesthetics, local trauma and haemorrhage. Acta Anaesthesiol Scand 1980; 24: 155-60.
34. Nicholson CD, Schmitt RM, Wilke R. The effect of acute and chronic femoral artery ligation on the blood flow through the gastrocnemius muscle of the rat examined using laser Doppler flowmetry and xenon-133 clearance. Int J Microcirc Clin Exp 1985; 4: 157-71.
35. Nilsson EN, Tenland T, Öberg Å. A new instrument for continuous measurement of tissue blood flow by light heating spectroscopy. IEEE Trans Biomed Eng 1980; 27: 12-19.
36. Steinhagen C, Hirche HJ, Nestle HW, Bovenkamp U, Hosselmann I. The interstitial pH of the working gastrocnemius muscle of the dog. Pflügers Arch 1976; 367: 151-56.
37. Burmester HBC, Aulton K, Horsfield G. Evaluation of a rapid method for the determination of plasma fibrinogen. J Clin Pathol 1970; 23: 43-46.
38. Bergmeyer HU. Glycerinaldehyde-3-phosphat-dehydrogenase. Methoden der enzymatischen Analyse. 2. Auflage, Band I. Verlag Chemie, Weinheim, 1970: 425.
39. Harris RC, Hultman E, Jordesjö L-O. Glycogen, glycolytic intermediates and high energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Scand J Clin Lab Invest 1974; 33: 109-20.
40. Reichmann H, Srihari T, Pette D. Ipsi- and contralateral fibre transformations by cross-reinnervation. A principle of symmetry. Pflügers Arch 1983; 397: 202-208.
41. Thulesius O. Haemodynamic studies on experimental obstruction of the femoral artery in the cat. Acta Physiol Scand 1962; 57 (suppl 199).
42. Sanne H, Sivertsson R. The effect of exercise on the development of collateral circulation after experimental occlusion of the femoral artery in the cat. Acta Physiol Scand 1968; 73: 257-63.
43. Conrad MC, Anderson JL, Garrett JB. Chronic collateral growth after femoral artery occlusion in the dog. J Appl Physiol 1971; 31: 550-55.
44. Hall JA, Dixson GH, Barnard RJ, Pritikin N. Effects of diet and exercise on peripheral vascular disease. Physician Sports Med 1982; 10: 90-101.
45. Sorlie D, Straume B, Grimsgaard C, Johnsrud NK. Arterial collateral vessels in legs with obliterative arteriosclerosis. Scand J Clin Lab Invest 1978; 38: 361-67.
46. Challiss RAJ, Heyes DJ, Radda GK. An investigation of arterial insufficiency in the rat hindlimb correlation of skeletal muscle blood flow and glucose utilization in vivo. Biochem J 1986; 240: 395-401.
47. Dormandy JA, Hoare E, Colley J, Arrowsmith DE, Dormandy TL. Clinical, haemodynamic, rheological and biochemical findings in 126 patients with intermittent claudication. Br Med J 1973; 4: 576-81.
48. Ehrly AM. New pathophysiological concept of ischaemic diseases: microcirculatory blood maldistribution (MBM). Bibl Anat 1981; 20: 456-60.
49. Holm J, Björntorp P, Scherstén T. Metabolic activity in human skeletal muscle. Effect of arterial reconstructive surgery. Scand J Clin Lab Invest 1975; 35: 81-86.
50. Bylund A-C, Hammarsten J, Holm J, Schertén T. Enzyme activities in skeletal muscle from patients with peripheral arterial insufficiency. Eur J Clin Invest 1976; 6: 425-29.
51. Holm J, Dahllöf A-G, Scherstén T. Metabolic activity of skeletal muscle in patients with peripheral arterial insufficiency. Effect of arterial reconstructive surgery. Scand J Clin Lab Invest 1975; 35: 81-86.
52. Sundberg C-J. Exercise and training during graded leg ischaemia in healthy man - with special reference to effects on skeletal muscle. Acta Physiol Scand 1994; 150 (suppl 615).
53. Sahlin K, Edström L, Sjöholm H, Hultman E. Effects of lactic acid accumulation and ATP decrease in muscle tension and relaxation. Am J Physiol 1981; 240: C121-C126.
54. Elander A, Idström J-P, Schersten T, Bylund-Fellenius A-C. Metabolic adaptation to reduced muscle blood flow. I. Enzyme and metabolic alterations. Am J Physiol 1985; 249: E63-E69.
55. + channel openers and 'natural' cardioprotection. Trends Pharmacol Sci 1992; 13: 269-72.
56. Lamping KA, Gross GJ. Comparative effects of a new nicotinamide nitrate derivative, nicorandil (SG 75), with nifedipine and nitroglycerin on true collateral blood flow following an acute coronary occlusion in dogs. J Cardiovasc Pharmacol 1984; 6: 601-608.
57. Hirata Y, Umemura K, Kondoh K, Uematsu T, Nakashima M. Experimental intimal thickening studies using the photochemically induced thrombosis model in the guinea-pig femoral artery. Atherosclerosis 1994; 107: 117-24.
58. Katsuragawa M, Fujuware H, Kawamura A et al. An animal model of coronary thrombosis and thrombolysis - comparisons of vascular damage and thrombus formation in the coronary and femoral arteries after balloon angioplasty. Jpn Circ J 1993; 57: 1000-1006.