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Lucarotti ME, Hamilton JA, Farndon JR: Somatostatin and primary hyperparathyroidism. Br J Surg 1994, 81(suppl 8):1141-1143. This work examines the efficacy of the somatostatin analogue octreotide in the management of primary hyperparathyroidism. Twenty one patients were admitted before parathyroid surgery and were treated for 6 days with subcutaneous octreotide at 100 μ g twice daily. Fasting blood samples were taken for determination of serum levels of calcium and parathyroid hormone, and urinary calcium excretion was measured every 24 hours before and after treatment. A significant decrease in urinary calcium was demonstrated, but the reduction in serum calcium was not statistically significant and there was no change in serum parathyroid hormone concentration. Octreotide may provide therapy for patients with hyperparathyroidism and for those who have undergone successful neck exploration or who are unfit for operation. It may also ameliorate hypercalciuria and reduce stone formation.
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Frank Raue K, Raue F, Ziegler R: Therapy of metastatic medullary thyroid gland carcinoma with the somatostatin analogue octreotide. Med Klin 1995, 90(suppl 2):63-66. In seven patients with metastasizing medullary thyroid carcinoma, the antisecretory and antiproliferative effects of somatostatin were evaluated in a prospective study. Treatment with octreotide in daily doses between 100 and 1000 μ g resulted in a remission lasting up to 12 months in two of seven patients. A decrease of tumor marker levels was observed in two patients; improvement of diarrhea and a remission of a lymph node metastasis in one of these. This minor therapeutic effect may be due to the relatively low density of receptors or with a low affinity of the receptors expressed in medullary thyroid carcinoma to octreotide.
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