LY290181, an inhibitor of diabetes-induced vascular dysfunction, blocks protein kinase C-stimulated transcriptional activation through inhibition of transcription factor binding to a phorbol response element

Diabetes

Volumn 45, Issue 5, 1996, Pages 642-650

  Birch, Kimberly A ^a   Heath, William F ^a   Hermeling, Ronald N ^a   Johnston, Cecile M ^a   Stramm, Larry ^a   Dell, Colin ^a   Smith, Colin ^a   Williamson, Joseph R ^b   Reifel Miller, Anne ^a  

^a ELI LILLY AND COMPANY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 CYANO 5,6 DIHYDRO 4 (4 TRIFLUOROMETHYLPHENYL) 4H NAPHTHO[1,2 B]PYRAN; 2 AMINO 4 (3 NITROPHENYL) 4H NAPHTHO[1,2 B]PYRAN 3 CARBONITRILE; 2 AMINO 4 (3 PYRIDYL) 4H NAPHTHO[1,2 B]PYRAN 3 CARBONITRILE; CHLORAMPHENICOL ACETYLTRANSFERASE; DNA; GLUCOSE; LY 270283; NUCLEAR PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; PLASMINOGEN ACTIVATOR; PROTEIN KINASE C; PYRAN DERIVATIVE; THYMIDINE KINASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UROKINASE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BINDING AFFINITY; CATTLE; CELL GROWTH; CONTROLLED STUDY; DIABETES MELLITUS; DNA BINDING; DOSE RESPONSE; GENE EXPRESSION; GRANULATION TISSUE; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPORTER GENE; RETINA; RETINA CAPILLARY; SCIATIC NERVE; VASCULAR DISEASE;

ANIMALS; BASE SEQUENCE; CAPILLARIES; CATTLE; CELLS, CULTURED; CHLORAMPHENICOL O-ACETYLTRANSFERASE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC ANGIOPATHIES; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FIBROBLASTS; HUMANS; MALE; MOLECULAR SEQUENCE DATA; NAPHTHALENES; OLIGODEOXYRIBONUCLEOTIDES; PHORBOL 12,13-DIBUTYRATE; PROMOTER REGIONS (GENETICS); PROTEIN KINASE C; PYRANS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; RETINAL VESSELS; SKIN; TETRADECANOYLPHORBOL ACETATE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; URINARY PLASMINOGEN ACTIVATOR;

EID: 0029974507     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.5.642     Document Type: Article

References (68)

1. Kreisberg JI: Biology of disease: Hyperglycemia and microangiopathy: direct regulation by glucose of microvascular cells. Lab Invest 67:416-426, 1992
2. King GL, Shiba T, Oliver J, Inoguchi T, Bursell SE: Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus. Annu Rev Med 45 179-188, 1994
3. Giannini C, Dyck PJ: Ultrastructural morphometric abnormalities of sural nerve endoneurial microvessels in diabetes mellitus. Ann Neurol 36:408-415, 1994
4. The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus N Engl J Med 329:977-986, 1993
5. Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, King GL: Preferential elevation of protein kinase C isoform bII and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci USA 89:11059-11063, 1992
6. Shiba T, Inoguchi T, Sportsman JR, Heath WF, Bursell S, King GL: Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol 265:E783-E793, 1993
7. Willaims B, Schrier RW: Characterization of glucose-induced in situ protein kinase C activity in cultured vascular smooth muscle cells. Diabetes 41:1464-1472, 1992
8. Struder RK, Craven PA, DeRubertis FR: Hole for protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high-glucose medium. Diabetes 42:118-126, 1993
9. Inoguchi T, Xia P, Kunisaki M, Higashi S, Feener EP, King GL: Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues. Am J Physiol 267:E369-E379, 1994
10. Kunisaki M, Bursell SE, Umeda F, Nawata H, King GL: Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels Diabetes 43:1372-1377, 1994
11. Lee TS, Saltsman KA, Ohashi H, King GL: Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications. Proc Natl Acad Sci USA 86:5141-5145, 1989
12. Tanaka Y, Kasluwagi A, Ogawa T, Abe N, Asashina T, Ikebuchi M, Takagi Y, Shigeta Y: Effect of verapamil on cardiac protein kinase C activity in rats Eur J Pharmacol 200:353-356, 1991
13. Craven PA, DeRubertis FR: Protein kinase C is activated in glomeruli from streptozotocin diabetic rats, possible mediation by glucose J Clin Invest 83:1667-1675, 1989
14. Wolf BA, Williamson JR, Eason RA, Chang K, Sherman WR, Turk J: Diacylglyeerol accumulation and microvascular abnormalities induced by elevated glucose levels. J Clin Invest 87:31-38, 1991
15. Tesfamariam B, Brown ML, Cohen RA: Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C. J Clin Invest 87:1643-1648, 1991
16. Pugliese G, Tilton R, Williamson JR: Glucose-induced metabolic imbalances in the pathogenesis of diabetic vascular disease. Diabetes Metab Rev 7:35-59, 1991
17. Karin M: The AP-1 complex and its role in transcriptional control by protein kinase C. In Molecular Aspects of Cellular Regulation Cohen P, Foulkes JG, Eds. New York, Elsevier, 1991, p. 235-253
18. Nerlov C, Rorth P, Blasi F, Johnsen M: Essential AP-1 and PEA3 binding elements in the human urokinase enhancer display cell-type specific activity. Oncogene 6:1583-1592, 1991
19. Gutman A, Wasylyk B: The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites. EMBO J 9:2241-2246, 1990
20. Buzney SM, Massicotte SJ, Hetu N, Zetter BR: Retinal vascular endothelial cells and pericytes: differential growth characteristics in vitro. Invest Ophthalmol Visual Sci 24:470-483, 1983
21. Voyta JC, Via DP, Butterfield CE, Zetter BR: Identification and isolation of endothelial cells based on their increased uptake of acetylated low-density lipoprotein J Cell Biol 99:2034-2040, 1984
22. Verheijen JH, Mullaart E, Chang GTG, Kluft C, Wijngaards G: A simple, sensitive spectrophotometric assay for extrinsic (tissue-type) plasminogen activator applicable to measurements in plasma. Thromb Haemostasis 48:266-269, 1982
23. Borenfreund E, Puerner J: A simple quantitative procedure using monolayer cultures for cytotoxicity assays. J Tissue Cult Methods 9:7, 1984
24. Manetta JV, Lai M-HT, Osborne HE, Dee A, Margolin N, Sportsman JR, Vlahos CJ, Yan SB, Heath WF: Design and implementation of a novel method for the detection of HIV-1 protease inhibitors. Anal Biochem 202:10-15, 1992
25. Lundberg C, Gerdin B: The inflammatory reaction in an experimental model of open wounds in the rat: the effect of arachidonic acid metabolites. Eur J Pharmacol 97:224-238, 1984
26. Williamson JR, Ostrow E, Eades D, Chang K, Allison W, Kilo C, Sherman WR: Glucose-induced microvascular functional changes in nondiabetic rats are stereospecific and are prevented by an aldose reductase inhibitor. J Clin Invest 85:1167-1172, 1990
27. Lowry OH, Passoneau JV: A Flexible System of Enzymatic Analysis. Orlando, FL, Academic, 1972
28. Tilton RG, Chang K, Hasan KS, Smith SR, Petrash JM, Misko TP, Moore WM, Currie MG, Corbett JA, McDaniel ML, Williamson JR: Prevention of diabetic vascular dysfunction by guanidines: inhibition of nitric oxide synthase versus advanced glycation end-product formation. Diabetes 42:221-232, 1993
29. Cassady A, Stacey KJ, Nimmo KA, Murphy KM, von der Ahe D, Pearson D, Botteri FM, Nagamine Y, Hume DA: Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5′ non-coding sequences that are conserved between mouse and pig. Nucleic Acids Res 19:6839-6847, 1991
30. Angel P, Baumann I, Stein B, Delius H, Rahmsdorf HJ, Herrlich P: 12-O-Tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5′-flanking region Mol Cell Biol 7:2256-2266, 1987
31. Wigler M, Pellicer A, Silverstein S, Axel R, Urlaub G, Chasin L: DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc Natl Acad Sci USA 76:1373-1376, 1979
32. Gorman, CM, Moffat LF, Howard BH: Recombinant genomes which express chloramphemcol acetyltransferase in mammalian cells. Mol Cell Biol 2:1044-1051, 1982
33. Dignam JD, Lebovitz RM, Roeder RG: Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489, 1983
34. Osborn L, Kunkel S, Nabel GJ: Tumor necrosis factor αand interleukin 1 stimulate the human immunodeficiency virus enhancer by activating the nuclear factor kB. Proc Natl Acad Sci USA 86:2336-2340, 1989
35. Carthew RW, Chodosh LA, Sharp PA: An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter. Cell 43:439-448, 1985
36. Anderson TW: An introduction to Muitivariate Analysis. New York, Wiley, 1958
37. Lehmann EL: Nonparametrics: Statistical Methods Based on Ranks. San Francisco, Holden-Day, 1975
38. Blom G: Statistical Estimates and Transformed Beta Variables. New York, Wiley, 1958
39. Vassalli JD, Belin D: Amiloride selectively inhibits the urokinase-type plasminogen activator. FEBS Lett 214:187-191, 1987
40. Verde P, Boast S, Franze A, Robbiati F, Blasi F: An upstream enhancer and a negative element in the 5′ flanking region of the human urokinase plasminogen activator gene. Nucleic Acids Res 16:10699-10716, 1988
41. Rorth P, Nerlov C, Blasi F, Johnsen M: Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor or phorbol-ester. Nucleic Acids Res 18:5009-5017, 1990
42. Nerlov C, De Cesare D, Pergola F, Caracciolo A, Blasi F, Johnsen M, Verde P: A regulatory element that mediates co-operation between a PEA3-AP-1 element and an AP-1 site is required for phorbol-ester induction of urokinase enhancer activity in HepG2 hepatoma cells. EMBO J 11:4573-4582, 1992
43. Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P, Karin M: Phorbol-ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729-739, 1987
44. Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR: Phosphorylation of c-jun mediated by MAP kinase. Nature 353:670-674, 1991
45. Hai T, Curran T: Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci USA 88:3720-3724, 1991
46. Kerppola TK, Curran T: Selective DNA binding by a variety of bZIP proteins. Mol Cell Biol 13:5479-5489, 1993
47. Kerppola TK, Curran T: Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun. Oncogene 9:675-684, 1993
48. Stein B, Baldwin AS Jr, Ballard DW, Greene WC, Angel P, Herrlich P: Cross-coupling of the NF-κB p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J 12 3879-3891, 1993
49. Rymaszewski Z, Szymanski PT, Abplanalp WA, Myatt L, Di Salvo J, Cohen RM: Human retinal vascular cells differ from umbilical cells in synthetic functions and their response to glucose. Proc Soc Exp Biol Med 199:183-191, 1992
50. Nordt TK, Klassen KJ, Schneider DJ, Sobel BE. Augmentation of synthesis of plasminogen activator inhibitor-1 in arterial endothelial cells by glucose and its implications for local fibrinolysis. Arterioscler Thromb 13:1822-1828, 1993
51. Maiello M, Boeri D, Podesta F, Cagliero E, Vichi M, Odetti P, Adezati L, Lorenzi M: Increased expression of tissue plasminogen activator and its inhibitor and reduced fibrinolytic potential of human endothelial cells cultured in elevated glucose. Diabetes 41:1009-1015, 1992
52. Laug WE, Weinblatt ME, Jones PA. Endothelial cells degrade extracellular matrix proteins produced in vitro. Thromb Haemostasis 54:498-502, 1985
53. Partridge CA, Horvath CJ, Del Vecchio PJ, Phillips PG, Malik AB: Contribution of extracellular matrix in tumor necrosis factor-induced increase in endothelial permeability. Am J Physiol 263:L627-L633, 1992
54. Partridge CA, Jeffrey JJ, Malik AB: A 96 kDa gelatinase induced by TNF-α contributes to increased microvascular endothelial permeability. Am J Physiol 265:L438-L447, 1993
55. Lynch JJ, Ferro TJ, Blumenstock FA, Brockenauer AM, Malik AB Increased endothelial albumin permeability mediated by protein kinase C activation. J Clin Invest 85:1991-1998, 1990
56. Goldfarb RH, Ziche M, Murano G, Liotta LA. Plasminogen activators (urokinase) mediate neovascularization: possible role in tumor angiogenesis. Semin Thromb Hemostasis 12:337-338, 1986
57. Berman M, Winthrop S, Ausprunk D, Rose J, Langer R, Gage J. Plasminogen activator (urokinase) causes vascularization of the cornea. Invest Ophthalmol Visual Sci 22:191-199, 1982
58. Mignatti P, Tsuboi R, Robbins E, Rifkin DB. In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases J Cell Biol 108:671-682, 1989
59. Montesano R, Pepper MS, Mohle-Steinlein V, Rusau W, Wagner EF, Orci L: Increased proteolytic activity is responsible for aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene. Cell 62:435-445, 1990
60. Montesano R, Orci L: Tumor-promoting phorbol-esters induce angiogenesis in vitro. Cell 42:469-477, 1985
61. Pepper MS, Belin D, Montesano R, Orci L, Vassalli D: Transforming growth factor beta modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. J Cell Biol 111:743-755, 1990
62. Wernert N, Raes MB, Lassalle P, Dehouch MP, Gosselin B, Vandenbunder B, Stehelin D: c-ets1 protooncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans Am J Pathol 140:119-127, 1992
63. Ziyadeh FN: Mediators of hyperglycemia and the pathogenesis of matrix accumulation in diabetic renal disease Miner Electrolyte Metab 21:292-302, 1995
64. Pfeiffer A, Schatz H: Diabetic microvascular complications and growth factors Exp Clin Endocrinol Diabetes 103:7-14, 1995
65. Cosio FG, Wilmer WA: Effects of high glucose concentration on c-fos: role of protein kinase C. Kidney Int 48:S12-S17, 1995
66. Kreisberg JI, Radnik RA, Ayo SH, Garoni J, Saikumar P. High glucose elevates c-fos and c-jun transcripts and proteins in mesangial cell cultures. Kidney Int 46:105-112, 1994
67. Cagliero E, Roth T, Roy S, Maiello M, Lorenzi M: Expression of genes related to the extracellular matrix in human endothelial cells: differential modulation by elevated glucose concentration, phorbol-esters, and cAMP. J Biol Chem 266:14244-14250, 1991
68. Peterson MG, Baichwal VR: Transcription factor based therapeutics, drugs of the future? Trends Biotechnol 11:11-18, 1993