Chronic dexamethasone administration decreases noradrenaline-stimulated, but not serotonin-stimulated, phosphoinositide metabolism in the rat brain

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 353, Issue 6, 1996, Pages 616-620

  Takahashi, Michihiro ^a   Morinobu, Shigeru ^a   Totsuka, Shiroh ^a   Endoh, Masao ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

1 Adrenoceptors; 5 HT2 receptors; Dexamethasone; Glucocorticoids; Phosphoinositide metabolism

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; DEXAMETHASONE; INOSITOL; INOSITOL PHOSPHATE; KETANSERIN; LITHIUM CHLORIDE; NORADRENALIN; PHOSPHATIDYLINOSITIDE; PRAZOSIN; RADIOISOTOPE; SEROTONIN; SEROTONIN 2A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPRESSION; DRUG ANTAGONISM; HIPPOCAMPUS; MALE; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CEREBRAL CORTEX; DEXAMETHASONE; GLUCOCORTICOIDS; HIPPOCAMPUS; MALE; NOREPINEPHRINE; PHOSPHATIDYLINOSITOLS; RATS; RATS, WISTAR; SEROTONIN;

EID: 0029974368     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00167180     Document Type: Article

References (24)

1. 2 serotonin receptors by lithium, sodium and potassium chloride. Life Sci 32:2597-2601
2. Bennett JP, Snyder SH (1975) Serotonin and lysergic acid diethylamide binding in rat brain membranes: relationship to post-synaptic serotonin receptors. Mol Pharmacol 12:373-389
3. Berridge MJ (1984) Inositol triphosphate and diacylglycerol as second messengers. Biochem J 220:345-360
4. Brown E, Kendall DA, Nahorski SR (1984) Inositol phospholipid hydrolysis in rat cerebral cortical slices: I. Receptor characterization. J Neurochem 42:1379-1387
5. Brown GM (1980) Psychiatric and neurologie aspects of endocrine disease. In: Krieger DT, Hughes JC (Eds) Neuroendocrinology. Sinauer, Sunderland, pp 185-193
6. Carroll BJ, Cutis GC, Mendels J (1976) Neuroendocrine regulation in depression. I: Limbic system-adrenocortical dysfunction. Arch Gen Psychiatry 33:1039-1044
7. Duman RS, Strada SJ, Enna SJ (1989) Glucocorticoid administration increases receptor-mediated and forskolin-stimulated cyclic AMP accumulation in rat brain cerebral cortical slices. Brain Res 477:166-171
8. 3H-prazosin to rat brain α-adrenergic receptors. Eur J Pharmacol 55:323-326
9. 1c receptors. Trends Pharmacol Sci 9:89-94
10. Janowsky A, Labarca R, Paul SM (1984) Characterization of neurotransmitter receptor-mediated phosphatidylinositol hydrolysis in the rat hippocampus. Life Sci 35:1953-1961
11. Kawanami T, Morinobu S, Toksuka S, Endoh M (1992) Influence of stress and antidepressant treatment on 5-HT-stimulated phosphoinositide hydrolysis in rat brain. Eur J Pharmacol 216:385-392
12. Kleuss C, Hescheler J, Ewel C, Rosenthal W, Schultz G, Wittig B (1991) Assignment of G-protein subtypes of specific receptors inducing inhibition of calcium currents. Nature 353:43-48
13. Kleuss C, Scherübl H, Hescheler J, Schultz G, Wittig B (1992) Different β-subunits determine G-protein interaction with transmembrane receptors. Nature 358:424-426
14. Kolasa K, Song L, Jope RS (1992) Adrenalectomy increases phosphoinositide hydrolysis induced by norepinephrine or excitatory amino acids in rat hippocampal slices. Brain Res 579:128-133
15. Lipinsky JF, Cohen B, Zubenko GS, Waternaux CM (1987) Adrenoceptors and the pharmacology of affective illness: a unifying theory. Life Sci 40:1947-1963
16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275
17. McEwen BS, De Kloet ER, Rostene W (1986) Adrenal steroid receptors and actions in the nervous system. Physiol Rev 66:1121-1188
18. Mobley PL, Manier DH, Sulser F (1983) Norepinephrine sensitive adenylate cyclase system in rat brain: role of adrenal corticosteroids. J Pharmacol Exp Ther 226:71-77
19. Morinobu S, Kuwayama N, Kawanami T, Okuyama N, Takahashi M, Totsuka S, Endoh M (1992) Influence of the acute stress on agonist-stimulated phosphoinositide hydrolysis in rat cerebral cortex. Prog Neuro-Psychopharmacol & Biol Psychiat 16:561-570
20. Munck A, Guyre P, Holbrook N (1984) Physiological functions of glucocorticoids during stress and their relation to pharmacological actions. Ender Rev 5:25-49
21. Nemeroff CB, Widerlöv E, Bissette G (1984) Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 226:1342-1344
22. Rose RM (1985) Psychoendocrinology. In: Wilson JP, Foster DW (eds) Williams textbook of endocrinology, 7th edn. Saunders, Philadelphia, pp 653-681
23. Scatchard G (1949) The attraction of proteins for small ions molecules. Ann NY Acad Sci 51:660-672
24. Wilckens T (1995) Glucocorticoids and immune function: physiological relevance and pathogenic potential of hormonal dysfunction. TiPS 16:193-197