Synthesis and structure-activity relationships of 2-substituted D-tryptophan-containing peptidic endothelin receptor antagonists: Importance of the C-2 substituent of the D-tryptophan residue for endothelin A and B receptor subtype selectivity

Journal of Medicinal Chemistry

Volumn 39, Issue 12, 1996, Pages 2313-2330

  Fukami, Takehiro ^a   Yamakawa, Takeru ^a   Niiyama, Kenji ^a   Kojima, Hisaki ^a   Amano, Yuuka ^a   Kanda, Fuyuko ^a   Ozaki, Satoshi ^a   Fukuroda, Takahiro ^a   Ihara, Masaki ^a   Yano, Mitsuo ^a   Ishikawa, Kiyofumi ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; RECEPTOR SUBTYPE; TRYPTOPHAN;

ANIMAL TISSUE; ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ISCHEMIA; NONHUMAN; STRUCTURE ACTIVITY RELATION; SWINE; VASOCONSTRICTION;

ANIMALS; DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PIPERIDINES; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SWINE; TRYPTOPHAN; VASODILATOR AGENTS;

EID: 0029974211     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9600914     Document Type: Article

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