Active site-directed thrombin inhibitors: α-Hydroxyacyl-prolyl-arginals, new orally active stable analogues of D-Phe-Pro-Arg-H

Seminars in Thrombosis and Hemostasis

Volumn 22, Issue 3, 1996, Pages 243-246

  Bajusz, Sandor ^a   Barabas, Eva ^a   Fauszt, Iren ^a   Feher, Andras ^a   Horvath, Gyula ^a   Juhasz, Attila ^a   Szabo, Gabriella A ^a   Szell, Erzsebet ^a  

^a Institute for Drug Research Budapest   (Hungary)

Author keywords

Anticoagulants; Arginals; Fibrinolysis; Thrombin; Thrombosis models

Indexed keywords

DEXTRO PHENYLALANYLPROLYLARGININAL; THROMBIN INHIBITOR; TRIPEPTIDE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; FIBRINOLYSIS; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEQUENCE ANALYSIS; THROMBOSIS;

EID: 0029974209     PISSN: 00946176     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-999014     Document Type: Article

References (6)

1. Bajusz S, E Széll, D Badgy, E Barabás, G Horváth, M Diószegi, Z Fittler, G Szabó, A Juhász, E Tomori, G Szilágyi: Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative: D-MePhe-Pro-Arg-H. J Med Chem 33:1729-1735, 1990.
2. Bajusz S, E Barabás, E Széll, D Bagdy: Peptide aldehyde inhibitors of the fibrinogen-thrombin reaction. In: Walter R, J Meinhofer (eds): Peptides: Chemistry, Structure and Biology. Ann Arbor Publications, Ann Arhor, MI, 1975, pp 603-608.
3. Bajusz S, E Barabás, P Tolnay, E Széll, D Bagdy: Inhibition of thrombin and trypsin by tripeptide aldehydes. Int J Pept Protein Res 12:217-221, 1978.
4. Bajusz S, E Széll, E Barabás, D Badgy: Structure-activity relationships among tripeptide aldehyde inhibitors of plasmin and thrombin. In: Rich DH, E Gross (eds): Peptides. Proceedings of the 7th American Peptide Symposium, 1981. Pierce Chemical Co., Rockford, IL, 1981, pp 417-420.
5. 4. Thromb Haemostas 67:325-330, 1992.
6. Badgy D, E Barabás, AG Szabo, S Bajusz, E Széll: In vivo anticoagulant and antiplatelet effect of D-Phe-Pro-Arg-H and D-MePhe-Pro-Arg-H. Thromb Haemostas 67:357-365, 1992.