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Volumn 12, Issue 2, 1996, Pages 125-134

Neurotoxic effect of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-pyridinium (HP+), a major metabolite of haloperidol, in the dopaminergic system in vitro and in vivo

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; CATECHOLAMINE; DOPAMINE; FREE RADICAL; HALOPERIDOL; NEUROLEPTIC AGENT; NEUROTOXIN; REDUCED HALOPERIDOL;

EID: 0029973802     PISSN: 01688561     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (11)

References (30)
  • 1
    • 0027430025 scopus 로고
    • Detection of a neurotoxic quaternary pyridinium metabolites in the liver of haloperidol-treated rats
    • Ablordeppey SY and Borne RF (1993) Detection of a neurotoxic quaternary pyridinium metabolites in the liver of haloperidol-treated rats. Pharmacol. Biochem. Behav. 46:739-744.
    • (1993) Pharmacol. Biochem. Behav. , vol.46 , pp. 739-744
    • Ablordeppey, S.Y.1    Borne, R.F.2
  • 2
    • 3342958560 scopus 로고
    • Neuronal transport of amines in vitro
    • (eds: Boulton AA, Baker GB and Baker JM) New Jersey: Humana Press
    • Baker GB and Dyck LE (1985) Neuronal transport of amines in vitro. In: Neuromethods: Neurochemistry II - Amines and their metabolites (eds: Boulton AA, Baker GB and Baker JM) New Jersey: Humana Press, pp457-534.
    • (1985) Neuromethods: Neurochemistry II - Amines and Their Metabolites , pp. 457-534
    • Baker, G.B.1    Dyck, L.E.2
  • 3
    • 0000209202 scopus 로고
    • Drugs and the treatment of psychiatric disorders
    • (eds: Gilman GA, Goodman LS, Rall TW and Murad F), New York: Macmillan
    • Baldessarini RJ (1985) Drugs and the treatment of psychiatric disorders. In: Pharmacological Basis of Therapeutics 7th edition (eds: Gilman GA, Goodman LS, Rall TW and Murad F), New York: Macmillan. pp. 385-445.
    • (1985) Pharmacological Basis of Therapeutics 7th Edition , pp. 385-445
    • Baldessarini, R.J.1
  • 4
    • 0028092822 scopus 로고
    • 1-Methyl-4-phenylpyridinium-like neurotoxicity of pyridinium metabolite derived from haloperidol: Cell culture and neurotransmitter uptake studies
    • Bloomquist J, King E, Wright A, Mytilineou C, Kimura K, Castagnoli K and Castagnoli NJr (1994) 1-Methyl-4-phenylpyridinium-like neurotoxicity of pyridinium metabolite derived from haloperidol: cell culture and neurotransmitter uptake studies. J. Pharmacol Exp. Ther. 270:822-830.
    • (1994) J. Pharmacol Exp. Ther. , vol.270 , pp. 822-830
    • Bloomquist, J.1    King, E.2    Wright, A.3    Mytilineou, C.4    Kimura, K.5    Castagnoli, K.6    Castagnoli Jr., N.7
  • 5
    • 0014142188 scopus 로고
    • Local glial reaction in the CNS of albino-rats in response to the administration of a neuroleptic drug (Butyrophenone)
    • Dom R (1967) Local glial reaction in the CNS of albino-rats in response to the administration of a neuroleptic drug (Butyrophenone). Acta Neurol. Belg. 67:755-762.
    • (1967) Acta Neurol. Belg. , vol.67 , pp. 755-762
    • Dom, R.1
  • 6
    • 0026066622 scopus 로고
    • Dehydration is the first step in the bioactivation of haloperidol to its pyridinium metabolite
    • Fang J and Gorrod JW (1991) Dehydration is the first step in the bioactivation of haloperidol to its pyridinium metabolite. Toxicol. Lett. 59:117-123.
    • (1991) Toxicol. Lett. , vol.59 , pp. 117-123
    • Fang, J.1    Gorrod, J.W.2
  • 7
    • 0027325176 scopus 로고
    • High-performance liquid chromatographic method for the detection and quantitation of haloperidol and seven of its metabolites in microsomal preparations
    • Fang J and Gorrod JW (1993) High-performance liquid chromatographic method for the detection and quantitation of haloperidol and seven of its metabolites in microsomal preparations. J. Chromatogr. 614:267-273.
    • (1993) J. Chromatogr. , vol.614 , pp. 267-273
    • Fang, J.1    Gorrod, J.W.2
  • 9
    • 0026714911 scopus 로고
    • Comparison of MPTP and amphetamines as dopaminergic neurotoxins
    • Fuller RW (1992) Comparison of MPTP and amphetamines as dopaminergic neurotoxins. Annals N.Y. Sci. 684: 87-95.
    • (1992) Annals N.Y. Sci. , vol.684 , pp. 87-95
    • Fuller, R.W.1
  • 10
    • 3342913432 scopus 로고
    • Extra-hepatic metabolism of drugs
    • (ed: Gorrod JW and Beckett AH) London: Taylor and Francis Ltd.
    • Gorrod JW (1978) Extra-hepatic metabolism of drugs, in: Drug Metabolism in Man. (ed: Gorrod JW and Beckett AH) London: Taylor and Francis Ltd. pp 157-174..
    • (1978) Drug Metabolism in Man , pp. 157-174
    • Gorrod, J.W.1
  • 11
    • 0027178379 scopus 로고
    • On the metabolism of haloperidol
    • Gorrod JW and Fang J (1993) On the metabolism of haloperidol. Xenobiotica 23:495-508.
    • (1993) Xenobiotica , vol.23 , pp. 495-508
    • Gorrod, J.W.1    Fang, J.2
  • 12
    • 0025070432 scopus 로고
    • Extrapyramidal symptoms in neuroleptic recipients
    • Basel, Birkhauser Verlag
    • Grohmann R, Koch R and Schmidt LG (1990) Extrapyramidal symptoms in neuroleptic recipients. In: Adverse Drug Reactions, Basel, Birkhauser Verlag, pp 71-82.
    • (1990) Adverse Drug Reactions , pp. 71-82
    • Grohmann, R.1    Koch, R.2    Schmidt, L.G.3
  • 13
    • 0026738182 scopus 로고
    • Determination of the pyridinium metabolite derived from haloperidol in brain tissue, plasma and urine by high-performance liquid chromatography with fluorescence detection
    • Igarashi K and Castagnoli NJr (1992) Determination of the pyridinium metabolite derived from haloperidol in brain tissue, plasma and urine by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. 579:277-283.
    • (1992) J. Chromatogr. , vol.579 , pp. 277-283
    • Igarashi, K.1    Castagnoli Jr., N.2
  • 14
    • 0000340348 scopus 로고
    • Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity
    • Javitch JA, D'Amato RJ, Strittmatter SM and Snyder SH (1985) Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc. Natl. Acad. Sci. USA 82:2173-2177.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 2173-2177
    • Javitch, J.A.1    D'Amato, R.J.2    Strittmatter, S.M.3    Snyder, S.H.4
  • 15
    • 0015548670 scopus 로고
    • Synaptic changes in the rabbit pallidum following long-term haloperidol administration. Folia
    • Koizumi J and Shiraishi H (1973) Synaptic changes in the rabbit pallidum following long-term haloperidol administration. Folia. Psychiatr. Neurol. Jpn. 27: 51-57.
    • (1973) Psychiatr. Neurol. Jpn. , vol.27 , pp. 51-57
    • Koizumi, J.1    Shiraishi, H.2
  • 16
    • 0023911192 scopus 로고
    • MPTP toxicity: Implications for research in Parkinson's disease
    • Kopin IJ, Markey SP (1988) MPTP toxicity: Implications for research in Parkinson's disease. Ann. Rev. Neurosci. 11:81-96.
    • (1988) Ann. Rev. Neurosci. , vol.11 , pp. 81-96
    • Kopin, I.J.1    Markey, S.P.2
  • 17
    • 0029042951 scopus 로고
    • Striatal dopamine participates in glutamate induced hydroxyl radical generation
    • Lancelot E, Callebert J, Plotkine M and Boulu RG (1995) Striatal dopamine participates in glutamate induced hydroxyl radical generation. NeuroReport 6:1033-1036.
    • (1995) NeuroReport , vol.6 , pp. 1033-1036
    • Lancelot, E.1    Callebert, J.2    Plotkine, M.3    Boulu, R.G.4
  • 18
    • 0020576386 scopus 로고
    • Selective presynaptic cholinergic neurotoxicity following intrahippocampal AF64A injections in rats
    • Mantione CR, Zigmond MJ and Fisher A and Hanin I (1983) Selective presynaptic cholinergic neurotoxicity following intrahippocampal AF64A injections in rats. J. Neurochem. 41:251-255.
    • (1983) J. Neurochem. , vol.41 , pp. 251-255
    • Mantione, C.R.1    Zigmond, M.J.2    Fisher, A.3    Hanin, I.4
  • 19
    • 0024400088 scopus 로고
    • Regional, reversible ultrastructural changes in rat brain with chronic neuroleptic treatment
    • Meshul CK and Casey DE (1989) Regional, reversible ultrastructural changes in rat brain with chronic neuroleptic treatment. Brain Res. 489:338-346.
    • (1989) Brain Res. , vol.489 , pp. 338-346
    • Meshul, C.K.1    Casey, D.E.2
  • 20
    • 0002037734 scopus 로고
    • Xenobiotic metabolism by brain monooxygenases and other cerebral enzymes
    • Mesnil M, Testa B and Jenner P (1984) Xenobiotic metabolism by brain monooxygenases and other cerebral enzymes. Adv. Drug Res. 13:195-207.
    • (1984) Adv. Drug Res. , vol.13 , pp. 195-207
    • Mesnil, M.1    Testa, B.2    Jenner, P.3
  • 21
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunological Methods 65:55-63.
    • (1983) J. Immunological Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 22
    • 0027354025 scopus 로고
    • N-Methylated tetrahydroisoquinolines as dopaminergic neurotoxins
    • Naoi M, Dostert P, Yoshida M and Nagatsu T (1993) N-Methylated tetrahydroisoquinolines as dopaminergic neurotoxins. Adv. Neurol. 60: 212-217.
    • (1993) Adv. Neurol. , vol.60 , pp. 212-217
    • Naoi, M.1    Dostert, P.2    Yoshida, M.3    Nagatsu, T.4
  • 23
    • 0021810979 scopus 로고
    • Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenylpyridi ne, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,23,6-tetrahydropyridine
    • Nicklas WJ, Vyas I and Heillila RE (1985) Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenylpyridi ne, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,23,6-tetrahydropyridine. Life Sci. 36:2503-2508.
    • (1985) Life Sci. , vol.36 , pp. 2503-2508
    • Nicklas, W.J.1    Vyas, I.2    Heillila, R.E.3
  • 24
    • 0022447784 scopus 로고
    • Energy-driven uptake of N-methyl-4 phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP
    • Ramsay RR, Dadgar J, Trevor A and Singer TP (1986) Energy-driven uptake of N-methyl-4 phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP. Life Sci. 39:581-588.
    • (1986) Life Sci. , vol.39 , pp. 581-588
    • Ramsay, R.R.1    Dadgar, J.2    Trevor, A.3    Singer, T.P.4
  • 25
    • 3342958559 scopus 로고
    • +, a pyridinium metabolite of haloperidol: A microdialysis study
    • (eds: Rollema H Westerink BHC and Drjfhout WJ) Groningen, Netherlands,. Univ. Groningen Press
    • +, a pyridinium metabolite of haloperidol: a microdialysis study. In: Mechanism of drug action, (eds: Rollema H Westerink BHC and Drjfhout WJ) Groningen, Netherlands,. Univ. Groningen Press pp 367-369.
    • (1991) Mechanism of Drug Action , pp. 367-369
    • Rollema, H.1    Subramanyam, B.2    Skolnik, M.3    D'Engelbronner, J.4    Castagnoli Jr., N.5
  • 27
    • 0025021896 scopus 로고
    • Intermittent and continuous haloperidol regimens produce different types of oral dyskinesias in rat
    • See RE and Ellison G (1990) Intermittent and continuous haloperidol regimens produce different types of oral dyskinesias in rat. Psychopharmacol. 100:404-412.
    • (1990) Psychopharmacol. , vol.100 , pp. 404-412
    • See, R.E.1    Ellison, G.2
  • 28
  • 29
    • 0025966719 scopus 로고
    • Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metabolite
    • Subramanyam B, Woolf T and Castagnoli NJr (1991) Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metabolite. Chem. Res. Tox. 4:123-128.
    • (1991) Chem. Res. Tox. , vol.4 , pp. 123-128
    • Subramanyam, B.1    Woolf, T.2    Castagnoli Jr., N.3
  • 30
    • 0025365202 scopus 로고
    • Spontaneous orofacial movements induced in rodents by very long-term neuroleptic drug administration: Phenomenology, and putative relationship to tardive dyskinesia
    • Weddington JL (1990) Spontaneous orofacial movements induced in rodents by very long-term neuroleptic drug administration: phenomenology, and putative relationship to tardive dyskinesia. Psychopharmacol. 101:431-447.
    • (1990) Psychopharmacol. , vol.101 , pp. 431-447
    • Weddington, J.L.1


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