Expression of nitric oxide synthase type II in the spinal cord under conditions producing thermal hyperalgesia

Journal of Chemical Neuroanatomy

Volumn 10, Issue 3-4, 1996, Pages 221-229

  Grzybicki, D ^a   Gebhart, G F ^a   Murphy, S ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Cytokine; Immunohistochemistry; In situ hybridization; Nitric oxide; Nociception; Rat

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1BETA; ISOENZYME; MESSENGER RNA; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BLOOD VESSEL; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME INDUCTION; ETIOLOGY; GRAY MATTER; HYPERALGESIA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD; WHITE MATTER;

EID: 0029973411     PISSN: 08910618     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-0618(96)00139-1     Document Type: Conference Paper

References (24)

1. Bredt, D.S., Hwang, P.M., Glatt, C.E., Lowenstein, C., Reed, R.R. and Snyder, S.H. (1991) Cloned and expressed nitric oxide synthase stucturally resembles cytochrome P-450 reductase. Nature 351, 714-718.
2. Dawson, T.M. and Dawson, V.L. (1995) Nitric oxide: actions and pathological roles. Neuroscientist 1, 7-18.
3. Dubner, R. and Ruda, M.A. (1992) Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci. 15, 96-102.
4. Dun, N.J., Dun, S.L., Fortstermann, U. and Tseng, L.F. (1992) Nitric oxide synthase immunoreactivity in rat spinal cord. Neurosci. Lett. 147, 217-220.
5. Glabinski, A.R., Tani, M., Stoler, M.H., Tuohy, V.K. and Ransohoff, R.M. (1995) Regulation and function of central nervous system chemokines. Int. J. Devel. Neuro Science 13, 156-165.
6. Hama, A.T. and Sagen, J. (1994) Induction of spinal NADPH-diaphorase by nerve injury is attenuated by adrenal medullary transplants. Brain Res. 640, 345-351.
7. Kitto, K.F., Haley, J.E. and Wilcox, G.L. (1992) Involvement of nitric oxide in spinally-mediated hyperalgesia in the mouse. Neurosci. Lett. 148, 1-5.
8. MacMicking, J.D., Nathan, C., Hom, G., Chartrain, N., Fletcher, D.S., Trumbauer, M., Stevens, K., Xie, Q., Sokol, K., Hutchinson, N., Chen, H. and Mudgett, J.S. (1995) Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81, 641-650.
9. Meller, S.T. and Gebhart, G.F. (1993) Nitric oxide and nociceptive processing in the spinal cord. Pain 52, 127-136.
10. Meller, S.T., Dykstra, C., and Gebhart, G.F. (1992a) Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-D-aspartate-produced facilitation of the nociceptive tail-flick reflex. Eur. J. Pharm. 214, 93-96.
11. Meller, S.T., Pechman, P.S., Gebhart, G.F. and Maves, T.J. (1992b) Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat. Neurosci. 50, 7-10.
12. Meller, S., Dykstra, C., Grzybicki, D., Murphy, S. and Gebhart, G.F. (1994) The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat. Neuropharmacol. 33, 1471-1478.
13. Montgomery, R.A. and Dallman, M.J. (1991) Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction. J. Immunol. 147, 554-560.
14. Nakane, M., Pollock, J.S., Klinghofer, V., Basha, F., Marsden, P.A., Hokari, A., Ogura, T., Esumi, H., and Carter, G.W. (1995) Functional expression of three isoforms of human nitric oxide synthase in baculovirus-infected insect cells. Biochem. Biophys. Res. Comm. 206, 511-517.
15. Perlman, S., Jacobsen, G. and Moore, S. (1988) Regional localization of virus in the CNS of mice persistently infected with murine coronavirus JHM. Virology 166, 328-338.
16. Rothwell, N.J. and Hopkins, S.J. (1995) Cytokines and the nervous system II: actions and mechanisms of action. Trends Neurosci. 18, 130-136.
17. Solodkin, A., Traub, R.J. and Gebhart, G.F. (1992) Unilateral hindpaw inflammation produces a bilateral increase in NADPH-diaphorase histochemical staining in the rat lumbar spinal cord. Neurosci. 51, 495-499.
18. Steel, J.H., Ternghi, G., Chung, J.M., Na, H.S., Carlton, S.M. and Polak, J.M. (1994) Increased nitric oxide synthase immunoreactivity in dorsal root ganglia in a neuropathic pain model. Neurosci. Lett. 169, 81-84.
19. Sun, N., Grzybicki, D., Castro, R.F., Murphy, S., and Perlman, S. (1995) Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus. Virol. 213, 482-493.
20. Valtschanoff, J.G., Weinberg, R.J. and Rustioni, A. (1992) NADPH diaphorase in the spinal cord of rats. J. Comp. Neurol. 321, 209-222.
21. Vauguri, P. and Farber, J.M. (1994) IFN and virus-inducible expression of an immediate early gene, crg-2/IP-10, and a delayed gene, 1-Aa, in astrocytes and microglia. J. Immunol. 152, 1411-1418.
22. Wei, X., Charles, I.G., Smith, A., Ure, J., Feng, G., Huang, F., Xu, D., Muller, W., Moncada, S. and Liew, F. (1995) Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 375, 408-411.
23. Xie, Q., Cho, H.J., Calaycay, J., Mumford, R.A., Swiderek, K.M., Lee, T.D., Ding, A., Troso, T. and Nathan, C. (1992) Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256, 225-228.
24. Yamamoto, T. and Shimoyama, N. (1995) Role of nitric oxide in the development of thermal hyperesthesia induced by sciatic nerve constriction injury in the rat. Anesthesiol. 82, 1266-1273.