Effects of aminoguanidine on rat pancreatic islets in culture and on the pancreatic islet blood flow of anaesthetized rats

Biochemical Pharmacology

Volumn 51, Issue 12, 1996, Pages 1711-1717

  Holstad, Maria ^a   Jansson, Leif ^a   Sandler, Stellan ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

aminoguanidine; blood flow; insulin release; nitric oxide; pancreatic islets

Indexed keywords

AMINOGUANIDINE; DNA; GLUCOSE; INSULIN; MICROSPHERE; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; GLUCOSE OXIDATION; INSULIN RELEASE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; RAT;

EID: 0029973369     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00105-0     Document Type: Article

References (45)

1. Corbett JA and McDaniel ML, Does nitric oxide mediate autoimmune destruction of β-cells? Possible therapeutic interventions in IDDM. Diabetes 41: 897-903, 1992.
2. Kolb H and Kolb-Bachofen V, Nitric oxide: a pathogenetic factor in autoimmunity. Immunol Today 13: 157-160, 1992.
3. Lowenstein CJ and Snyder SH, Nitric oxide, a novel biologic messenger. Cell 70: 705-707, 1992.
4. Prince RC and Gunson DE, Rising interest in nitric oxide synthase. Trends Biochem Sci 18: 35-36, 1993.
5. Lukic ML, Stosic-Grujicic S, Ostojic N, Chan WL and Liew FY, Inhibition of nitric oxide generation affects the induction of diabetes by streptozocin in mice. Biochem Biophys Res Commun 178: 913-920, 1991.
6. Kolb H, Kiesel U, Kröncke K-D and Kolb-Bachofen V, Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor. Life Sci 49: PL213-PL-217, 1991.
7. Corbett JA, Tilton RG, Chang K, Hasan KS, Ido Y, Wang JL, Sweetland MA, Lancaster Jr JR, Williamsson JR and McDaniel ML, Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetes vascular dysfunction. Diabetes 41: 552-556, 1992.
8. Misko TP, Moore WM, Kasten TP, Nickols GA, Corbett JA, Tilton RG, McDaniel ML, Williamsson JR and Currie MG, Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur J Pharmacol 233: 119-126, 1993.
9. G-nitro-L-arginine, and aminoguanidine on constitutive and inducible nitric oxide synthase in rat aorta. Biochem Biophys Res Commun 199: 147-154, 1994.
10. Tilton RG, Chang K, Corbett JA, Misko TP, Currie MG, Bora NS, Kaplan HJ and Williamsson JR, Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production. Invest Ophthalmol Vis Sci 35: 3278-3288, 1994.
11. Cross AH, Misko TP, Lin RF, Hickey WF, Trotter JL and Tilton RG, Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. J Clin Invest 93: 2684-2690, 1994.
12. Brownlee M, Vlassara H, Kooney A, Ulrich P and Cerami A, Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Science 232: 1629-1632, 1986.
13. Makita Z, Bucala R, Rayfield EJ, Friedman EA, Kaufman AM, Korbet SM, Barth RH, Winston JA, Fuh H, Manogue KR, Cerami A and Vlassara H, Reactive glycosylation endproducts in diabetic uraemia and treatment of renal failure. Lancet 343: 1519-1522, 1994.
14. Corbett JA, Mikhael A, Shimizu J, Frederick K, Misko TP, McDaniel ML, Kanagawa O and Unanue ER, Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process. Proc Natl Acad Sci USA 90: 8992-8995, 1993.
15. G-monomethyl-L-arginine on the onset of diabetes in the spontaneously diabetic BB rat. Diabetes 44: 360-364, 1995.
16. Holstad M and Sandler S, Aminoguanidine, an inhibitor of nitric oxide formation, fails to protect against insulitis and hyperglycemia induced by multiple low dose streptozotocin injections in mice. Autoimmunity 15: 311-314, 1993.
17. Sandler S and Andersson A, Cryopreservation of mouse pancreatic islets: effects of different glucose concentrations in the post-thaw culture medium on islet recovery. Cryobiology 24: 285-291, 1987.
18. Eizirik DL, Strandell E and Sandler S, Culture of mouse pancreatic islets in different glucose concentrations modifies B cell sensitivity to streptozotocin. Diabetologia 31: 168-174, 1988.
19. Sandler S, Bendtzen K, Eizirik DL, Strandell E, Welsh M and Welsh N, Metabolism and β-cell function of rat pancreatic islets exposed to human interleukin-1β in the presence of a high glucose concentration. Immunol Lett 26: 245-252, 1990.
20. Sandler S, Andersson A and Hellerström C, Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of rat pancreatic islets. Endocrinology 121: 1424-1431, 1987.
21. Heding LG, Determination of total serum insulin (IRI) in insulin-treated patients. Diabetologia 8: 260-266, 1972.
22. Krebs HA and Henseleit K, Untersuchungen über die Harnstoffbildung im Tierkörper. Hoppe-Seylers Z Physiol Chem 210: 33-66, 1932.
23. Hinegardner RT, An improved fluorometric assay for DNA. Anal Biochem 39: 197-201, 1971.
24. Andersson A and Sandler S, Viability tests of cryopreserved endocrine pancreatic cells. Cryobiology 20: 161-168, 1983.
25. Jansson L and Hellerström C, Stimulation by glucose of the blood flow to the pancreatic islets of the rat. Diabetologia 25: 45-50, 1983.
26. Jansson L and Hellerström C, A rapid method of visualizing the pancreatic islets for studies of islet capillary blood flow using non-radioactive microspheres. Acta Physiol Scand 113: 371-374, 1981.
27. Wolff DJ and Lubeskie A, Aminoguanidine is an isoform-selective, mechanism-based inactivator of nitric oxide synthase. Arch Biochem Biophys 316: 290-301, 1995.
28. Laychock SG, Modica ME and Cavanaugh CT, L-arginine stimulates cyclic guanosine 3′,5′-monophosphate formation in rat islets of Langerhans and RINm5F insulinoma cells: evidence for L-arginine: nitric oxide synthase. Endocrinology 129: 3043-3052, 1991.
29. Schmidt HHHW, Warner TD, Ishii K, Sheng H and Murad F, Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. Science 255: 721-723, 1992.
30. Jones PM, Persaud SJ, Bjaaland T, Pearson JD and Howell SL, Nitric oxide is not involved in the initiation of insulin secretion from rat islets of Langerhans. Diabetologia 35: 1020-1027, 1992.
31. Vincent SR, Nitric oxide and arginine-evoked insulin secretion. Science 258: 1376, 1992.
32. Svensson C and Hellerström C, Long-term effects of a high glucose concentration in vitro on the oxidative metabolism and insulin production of isolated rat pancreatic islets. Metabolism 40: 513-518, 1991.
33. Southern C, Schulster D and Green IC, Inhibition of insulin secretion by interleukin-1β and tumour necrosis factor-α via an L-arginine-dependent nitric oxide generating mechanism. FEBS Lett 276: 42-44, 1990.
34. Welsh N, Eizirik DL, Bendtzen K and Sandler S, Interleukin-1β-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Endocrinology 129: 3167-3173, 1991.
35. Tasaka Y, Nakaya F, Matsumoto H and Omori Y, Effects of aminoguanidine on insulin release from pancreatic islets. Endocrine J 41: 309-313, 1994.
36. Zähner D and Malaisse WJ, Effects of advanced glycation products and aminoguanidine upon insulin release. Diab Nutr Metab 5: 43-46, 1992.
37. Hutton JC, Sener A, Herchuelz A, Valverde I, Boscher AC and Malaisse WJ, The stimulus secretion coupling of glucose-induced insulin release, XLII. Effects of extracellular pH on insulin release: their dependency on nutrient concentration. Horm Metab Res 12: 294-299, 1980.
38. Arkhammar P, Berggren P-O and Rorsman P, Direct evidence for opposite effects of D-glucose and D-glyceraldehyde on cytoplasmic pH of mouse pancreatic β-cells. Biosci Rep 6: 355-361, 1986.
39. Palmer RMJ, Ferrige AG and Moncada S, Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524-526, 1987.
40. Jansson L, Whole pancreatic blood flow and islet blood flow in hypovolemic hypotension in rats. Eur Surg Res 24: 291-297, 1992.
41. Hindlycke M and Jansson L, Isovolemic hemodilution and pancreatic islet blood flow in the rat. Int Surg 78: 254-256, 1993.
42. G-nitro-L-arginine causes preferential decrease in pancreatic islet blood flow in normal rats and spontaneously diabetic GK rats. Endocrinology 135: 849-853, 1994.
43. Suscheck C, Fehsel K, Kröncke K-D, Sommer A and Kolb-Bachofen V, Primary culture of rat islet capillary endothelial cells - constitutive and cytokine-inducible macrophagelike nitric oxide synthases are expressed and activities regulated by glucose concentration. Am J Pathol 145: 685-695, 1994.
44. Jansson L and Hellerström C, Glucose-induced changes in pancreatic islet blood flow mediated by central nervous system. Am J Physiol 251: E644-E647, 1986.
45. Eizirik DL, Sandler S, Welsh N, Cetkovic-Cvrlje M, Niemann A, Geller DA, Pipeleers DG, Bendtzen K and Hellerström C. Cytokines supress human islet functions irrespective of their effects on nitric oxide generation. J Clin Invest 93: 1968-1974, 1994.