Unexpected genetic toxicity to rodents of the N′,N′-dimethyl analogues of MNU and ENU

Environmental and Molecular Mutagenesis

Volumn 27, Issue 3, 1996, Pages 202-210

  Tinwell, H ^a   Paton, D ^a   Guttenplan, J B ^b   Ashby, J ^a  

^a ASTRAZENECA   (United Kingdom)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

NH2; ENU; Hydrolysis; Methylation; MNU

Indexed keywords

ETHYLNITROSOUREA; METHYLNITROSOUREA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENOTOXICITY; HYDROLYSIS; MALE; METHYLATION; MICRONUCLEUS TEST; MOUSE; MUTAGENICITY; NONHUMAN; SALMONELLA TYPHIMURIUM;

ALKYLATING AGENTS; ANIMALS; BONE MARROW; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLNITROSOUREA; HALF-LIFE; HYDROLYSIS; MALE; METHYLNITROSOUREA; MICE; MICE, INBRED CBA; MICRONUCLEUS TESTS; MUTAGENS; SALMONELLA TYPHIMURIUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029972813     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1996)27:3<202::AID-EM5>3.0.CO;2-G     Document Type: Article

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