MS-271, A novel inhibitor of calmodulin-activated myosin light chain kinase from Streptomyces sp. - II. Solution structure of MS-271: Characteristic features of the 'lasso' structure

Bioorganic and Medicinal Chemistry

Volumn 4, Issue 1, 1996, Pages 121-129

  Katahira, Ritsuko ^a   Yamasaki, Motoo ^a   Matsuda, Yuzuru ^a   Yoshida, Mayumi ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

1H NMR; Distance geometry; Inhibitor; Lasso structure; MLCK; Simulated annealing

Indexed keywords

STREPTOMYCES SP.;

CYCLOPEPTIDE; ENZYME INHIBITOR; MS 271; MYOSIN LIGHT CHAIN KINASE; RP 71955; SIAMYCIN II; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; COMPUTER SIMULATION; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYOSIN-LIGHT-CHAIN KINASE; PEPTIDES; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; STREPTOMYCES;

EID: 0029972742     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/0968-0896(95)00176-X     Document Type: Article

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