Medullary vasomotor activity and hypoxic sympathoexcitation in pentobarbital-anesthetized rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 270, Issue 2 39-2, 1996, Pages

  Sun, Miao Kun ^a   Reis, Donald J ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

chemoreflexes; hypoxia; medullary vasomotor neurons; pressor response

Indexed keywords

ADRENERGIC ACTIVITY; ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HYPOXIA; MALE; MICROINJECTION; NONHUMAN; PATHOPHYSIOLOGY; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; SYMPATHETIC NERVE; VASOMOTOR REFLEX;

EID: 0029972736     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1996.270.2.r348     Document Type: Article

References (30)

1. Brown, D. L., and P. G. Guyenet. Electrophysiological study of cardiovascular neurons in the rostral ventrolateral medulla in rats. Circ. Res. 56: 359-369, 1985.
2. Cochrane, K. L., R. A. Buchholz, T. K. Keeton, and M. A. Nathan. Hypotensive effects of lesions of the rostral ventrolateral medulla in rats is anesthetic-dependent J. Auton. Nerv. Syst. 22: 181-187, 1988.
3. Cochrane, K. L., and M. A. Nathan. Cardiovascular effects of lesion of the rostral ventrolateral medulla and the nucleus reticularis parvocellularis in rats. J. Auton. Nerv. Syst. 43: 69-82, 1993.
4. Cochrane, K. L., and M. A. Nathan. Presser systems involved in the maintenance of arterial pressure after lesions of the rostral ventrolateral medulla. J. Auton. Nerv. Syst. 46: 9-18, 1993.
5. Dampney, R. A. L. The subretrofacial vasomotor nucleus anatomical, chemical and pharmacological properties and role in cardiovascular regulation. Prog. Neurobiol. 42: 197-227, 1994
6. Franks, N. P., and W. R. Lieb. Molecular and cellular mechanism of general anaesthesia. Nature Lond. 367: 607-614, 1994
7. Guyton, A. C. Blood pressure control-special role of the kidneys and body fluids. Science Wash. DC 252: 1813-1816, 1991.
8. Hess, R., and K. Murata. Effects of glutamate and GABA on specific response properties of neurones in the visual cortex. Exp Brain Res. 21: 285-297, 1974.
9. Hilton, S. M., and J. M. Marshall. The pattern of cardiovascular response to carotid chemoreceptor stimulation in the cat. J Physiol. Lond. 326: 495-513, 1982.
10. Koshiya, N., D. Huangfu, and P. G. Guyenet. Ventrolateral medulla and sympathetic chemoreflex in the rat. Brain Res. 609 63-84, 1993.
11. Nicholson, C. Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity. Brain Res. 333: 325-329, 1985.
12. Reis, D. J., E. V. Golanov, D. A. Ruggiero, and M.-K. Sun. Sympatho-excitatory neurons of the rostral ventrolateral medulla are oxygen sensors and essential elements in the tonic and reflex control of the systemic and cerebral circulation. J. Hyper tens. 12, Suppl.: S159-S180, 1994.
13. Ross, C. A., D. A. Ruggiero, T. H. Job, D. H. Park, and D. J. Reis. Rostral ventrolateral medulla: selective projections to the thoracic autonomic cell column from the region containing C1 adrenaline neurons. J. Comp. Neurol. 228: 168-185, 1984.
14. Ross, C. A., D. A. Ruggiero, D. H. Park, T. H. Job, A. F. Sved, J. Fernandez-Pardal, J. M. Saavedra, and D. J. Reis. Tonic vasomotor control by the rostral ventrolateral medulla: effect of electrical or chemical stimulation of the area containing C1 adrenaline neurons on arterial pressure, heart rate, and plasma catecholamines and vasopressm. J. Neurosci. 4: 474-494, 1984.
15. Spyer, K. M. Annual Review Prize Lecture: central nervous mechanisms contributing to cardiovascular control. J. Physiol. Lond. 474: 1-19, 1994.
16. Stith, R. D., and K. J. Domer. Pressor and endocrine responses to lesions of canine rostral ventrolateral medulla. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H2520-H2526, 1994.
17. Sun, M.-K., and P. G. Guyenet. GABA-mediated baroreceptor inhibition of reticulospinal neurons. Am. J. Physiol. 249 (Regulatory Integrative Comp. Physiol. 18): R672-R680, 1985.
18. Sun, M.-K., and P. G. Guyenet. Arterial baroreceptor and vagal inputs to sympathoexcitatory neurons in rat medulla Am. J. Physiol. 252 (Regulatory Integrative Comp. Physiol. 21 ): R699-R709, 1987.
19. Sun, M.-K., I. T. Jeske, and D. J. Reis. Cyanide excites medullary sympathoexcitatory neurons in rats. Am. J. Physiol. 262 (Regulatory Integrative Comp. Physiol. 31): R182-R189, 1992.
20. Sun, M.-K., and D. J. Reis. Differential responses of barosensitive neurons of rostral ventrolateral medulla to hypoxia in rats. Brain Res. 609: 333-337, 1993.
21. Sun, M.-K., and D. J. Reis. Hypoxia selectively excites vasomotor neurons of rostral ventrolateral medulla in rats. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol. 35): R245-R256, 1994.
22. Sun, M.-K., and D. J. Reis. Intrathecal kynurenate but not benextramine blocks hypoxic sympathoexcitation in chemodenervated anesthetized rats. J. Auton. Nerv. Syst. 47: 141-150, 1994.
23. Sun, M.-K., and D. J. Reis. Central neural mechanisms mediating excitation of sympathetic neurons by hypoxia Prog. Neurobiol. 44: 197-219, 1994.
24. Sun, M.-K., and D. J. Reis. NMDA receptor-mediated sympathetic chemoreflex excitation of RVL-spinal vasomotor neurones in rats. J. Physiol. Lond. 482: 53-68, 1995.
25. Sun, M.-K., and K. M. Spyer. Reticulospinal vasomotor neurones in decerebrate rats: effect of pentobarbitone. J. Auton. Nerv. Syst. 33: 85-90, 1991.
26. Vasquez, E. C., S. J. Lewis, K. J. Varner, and M. J. Brody. Chronic lesion of rostral ventrolateral medulla in spontaneously hypertensive rats. Hypertension Dallas 19, Suppl. II: II-154-II-158, 1992.
27. Willette, R. N., A. J. Krieger, P. P. Barcas, and H. N. Sapru. Medullary γ-aminobutyric acid (GABA) receptors and the regulation of blood pressure in the rat. J. Pharmacol. Exp. Ther. 226: 893-899, 1983.
28. Willette, R. N., S. Punnen, A. J. Krieger, and H. N. Sapru. Interdependence of rostral and caudal ventrolateral medullary areas in the control of blood pressure. Brain Res. 321: 169-174, 1984.
29. Yaksh, T. L., and T. A. Rudy. Chronic catheterisation of the spinal subarachnoid space. Physiol. Behav. 17: 1031-1036, 1976.
30. Zhong, S., Z.-S. Huang, and S. M. Barman. The 10-Hz sympathetic rhythm is dependent on raphe and rostral ventrolateral medullary neurons. Ant. J. Physiol. 264 (Regulatory Integrative Comp. Physiol. 33): R857-R866, 1993.