UV-B-induced cell cycle perturbations, micronucleus induction, and modulation by caffeine in human keratinocytes

International Journal of Radiation Biology

Volumn 69, Issue 3, 1996, Pages 371-384

  Weller, E M ^a   Hain, J ^a   Jung, T ^a   Kinder, R ^b   Kofferlein M ^c   Burkart, W ^a   Nusse M ^b  

^a BUNDESAMT FÜR STRAHLENSCHUTZ   (Germany)

^b AG Durchflußzytometrie   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CAFFEINE;

ARTICLE; CELL CYCLE; CONTROLLED STUDY; GAMMA RADIATION; HUMAN; HUMAN CELL; KERATINOCYTE; MICRONUCLEUS; PRIORITY JOURNAL; ULTRAVIOLET B RADIATION;

CAFFEINE; CELL CYCLE; CELL LINE; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; FLOW CYTOMETRY; G2 PHASE; GAMMA RAYS; HUMANS; KERATINOCYTES; KINETICS; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MITOSIS; S PHASE; ULTRAVIOLET RAYS;

EID: 0029972580     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530096145931     Document Type: Article

References (33)

1. BENDER, M. A., GRIGGS, H. G. and WALKER, P. L., 1973, Mechanisms of chromosomal aberration production. I. Aberration induction of ultraviolet light. Mutation Research, 20, 387-402.
2. BEISKER, W., 1994, A new combined integral-light and slit-scan data analysis system (DAS) for flow cytometry. Computer Methods and Programs in Biomedicine, 42, 15-26.
3. CLEAVER, J. E. and KRAEMER, K. H., 1989, Xeroderma pigmentosum. In: The Metabolic Basis of Inherited Desease. Edited by: C. R. Scriver, A. L. Beaudet, W. S. Sky and D. Volle (McGraw-Hill, New York), pp. 2949-2971.
4. COX, L. S. and LANE, D. P., 1995, Tumour supressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage. BioEssays, 17, 501-508.
5. ELWOOD, J. M., GALLAGHER, R. P., HILL, . B. and PEARSON, J. C. G., 1985, Cutaneous melanoma in relation to intermittent and constant sun exposure - the Western Canada melanoma study. International Journal of Cancer, 3, 427-433.
6. FREEMAN, S. E., HACHAM, H., GANGE, R. W., MAYTUM, D. J., SUTHERLAND, J. C. and SUTHERLAND, B. M., 1989, Wavelength dependence of pyrimidine dimer formation in DNA of human skin irradiated in situ with ultraviolet light. Proceedings of the National Academy of Sciences, USA, 86, 5605-5609.
7. FRIEDBERG, E. C. (ed.), 1985, DNA repair (Freeman, New York).
8. cdc2 activation. Cancer Research, 53, 1507-1510.
9. HAIN, J., JAUSSI, R. and WÜRGLER, F. E., 1994, Effects of ionizing radiation and caffeine treatment on cyclin dependent kinase complexes in V79 hamster cells. Cellular Signalling, 6, 539-550.
10. HART, R. W., SETLOW, B. and WOODHEAD, A. D., 1977, Evidence that pyrimidine dimers in DNA can give rise to tumors. Proceedings of the National Academy of Sciences, USA, 74, 5574-5578.
11. HARTWELL, L. H. and WEINERT, T. H., 1989, Checkpoints: controls that ensure the order of cell cycle events. Science, 246, 629-634.
12. HOY, C. A., CARSWELL, C. and SCHIMKE, R. T., 1993, Bromodeoxyuridine/DNA analysis of replication in CHO cells after exposure to UV light. Mutation Research, 290, 217-230.
13. KASTAN, M. B., ONYEKWERE, O., SIDRANSKY, D., VOGELSTEIN, B. and CRAIG, R., 1991, Participation of p53 protein in the cellular response to DNA damage. Cancer Research, 51, 6304-6311.
14. 1 arrest and cell-cycle-dependent clastogenesis in UV-irradiated human fibroblasts. Mutation Research, 314, 67-76.
15. KRAEMER, K. H., LEE, M. M. and SCOTTO, M. S., 1987, Xeroderma pigmentosum, cutaneous, ocular, and neurological abnormalities in 830 published cases. Archives of Dermatology, 123, 241-250.
16. KUBBIES, M., 1992, High resolution cell cycle analysis: the flow cytometric bromodeoxyuridine-Hoechst quenching technique. In: Flow Cytometry and Cell Sorting. Edited by: A. Radbruch (Berlin, Heidelberg, New York: Springer), pp. 75-85.
17. KUBBIES, M. and RABINOVITCH, P. S., 1983, Flow cytometric analysis of factors which influence the BrdU/Hoechst quenching effect in cultivated human fibroblasts and lymphocytes. Cytometry, 3, 276-281.
18. LAU, C. C. and PARDEE, A. B., 1982, Mechanisms by which caffeine potentiates lethality of nitrogen mustard. Proceedings of the National Academy of Sciences, USA, 79, 2942-2946.
19. LOCK, R. B. and Ross, W. E., 1990, Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells. Cancer Research, 50, 3761-3766.
20. MUSCHEL, R. J., ZANG, H. B. and MCKENNA, W. G., 1993, Differential effect of ionizing radiation on the expression of cyclin A and cyclin B in HeLa cells. Cancer Research, 53, 1128-1135.
21. 2/M-phase subpopulations in mammalian cell nuclei using side scatter and DNA content measurements. Cytometry, 11, 813-821.
22. NÜSSE, M. and KRAMER, J., 1984, Flow cytometric analysis of micronuclei found in cells after irradiation. Cytometry, 5, 20-25.
23. NÜSSE, M., KRAMER, J. and MILLER, B. M., 1992, Factors influencing the DNA content of radiation-induced micronuclei. International Journal of Radiation Biology, 62, 587-602.
24. ORMEROD, M. G. and KUBBIES, M. 1992, Cell cycle analysis of asynchronous cell populations by flow cytometry using Bromodeoxyuridine label and Hoechst-propidium iodide stain. Cytometry, 13, 678-685.
25. PROTIC-SABLJIC, M., TUTEJA, N., MUNSON, P. J., HAUSER, J., KRAEMER, K. H. and DIXON, K., 1986, UV-light induced cyclobutane pyrimidine dimers are mutagenic in mammalian cells. Molecular Cell Biology, 6, 3349-3356.
26. RABINOVITCH, P. S., 1983, Regulation of human fibroblast growth rate by both noncycling cell fraction and transition probability is shown by growth in 5-bromo-deoxyuridine followed by Hoechst 33258 flow cytometry. Proceedings of the National Academy of Sciences, USA, 80, 2951-2955.
27. RABINOVITCH, P. S., KUBBIES, M., CHEN, Y. G., SCHINDLER, D. and HOEHN, H., 1988, BrdU/Hoechst flow cytometry. A unique tool for quantitative cell cycle analysis. Experimental Cell Research, 174, 309-318.
28. TEVINI, M., 1993, UV B Radiation and Ozone Depletion: Effects on Humans, Animals, Plants, Microorganisms, and Materials (CRC, Florida).
29. TAYLOR, H. R., 1989, The biological effects of UV B on the eye. Photochemistry and Photobiology, 50, 489-492.
30. TOLMACH, L. J., JONES, W. and BUSSE, P. M., 1977, The action of caffeine on X-irradiated HeLa cells. Radiation Research, 71, 653-665.
31. WALTERS, R. A., GURLEY, L. R. and TOBEY R. A., 1974, Effects of caffeine on radiation-induced phenomena associated with cell-cycle traverse of mammalian cells. Biophysical Journal, 14, 199-117.
32. WELLER, E. M., DIETRICH, I., VIAGGI, S., BEISKER, W. and NÜSSE, M., 1993, Flow cytometric analysis of bromodeoxyuridine (BrdU)-induced micronuclei. Mutagenesis, 8, 437-444.
33. WELLER, E. M., KUBBIES, M. and NÜSSE, M., 1995, Induction of cell cycle perturbations by the tear gas 2-chlorobenzylidene malonitrile in synchronously and asynchronously proliferating mammalian cells. Cytometry, 19, 334-342.