Glyburide-reversible cardioprotective effects of calcium-independent phospholipase A2 inhibition in ischemic rat hearts

Cardiovascular Research

Volumn 31, Issue 2, 1996, Pages 270-277

  Sargent, Carol A ^a   Wilde, Mary W ^a   Dzwonczyk, Steven ^a   Tuttle, Jeffrey G ^a   Murray, Holt N ^a   Atwal, Karnail ^a   Grover, Gary J ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

ATP sensitive; Calcium independent PLA2; Coronary blood flow; Myocardial ischemia; Phospholipase A2; Potassium channel; Rat, heart; Sulphonylureas

Indexed keywords

5 HYDROXYDECANOIC ACID; BROMOENOL LACTONE; GLIBENCLAMIDE; LACTATE DEHYDROGENASE; PHOSPHOLIPASE A2; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART MUSCLE ISCHEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CALCIUM; CORONARY CIRCULATION; DECANOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYBURIDE; HEART; HYDROXY ACIDS; L-LACTATE DEHYDROGENASE; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; NA(+)-K(+)-EXCHANGING ATPASE; NAPHTHALENES; PHOSPHOLIPASES A; PYRONES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0029972445     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/0008-6363(95)00198-0     Document Type: Article

References (34)

1. Corr PB, Saffitz JE, Sobel BE. Lysophospholipids, long chain acylcarnitines and membrane dysfunction in the ischemic heart. Basic Res Cardiol 1987;82:199-208.
2. Otani H, Prasad RM, Jones RM, Das DK. Mechanism of membrane phospholipid degradation in ischemic-reperfused rat hearts. Am J Physiol 1989;257:H252-H253.
3. 2 (s); comparison of arachidonyl-selective and -non-selective enzymes. FASEB J 1993;7:339-348.
4. 2 inhibitors quinacrine and 7,7-dimethyleicosadienoic acid in isolated globally ischemic rat hearts. J Pharmacol Exp Ther 1992;262:1161-1167.
5. 2 and their membrane substrates. Trends Cardiovasc Med 1992;2:115-121.
6. 2 isoforms: activation by physiologic concentrations of calcium ion. J Biol Chem 1986;261:10467-10470.
7. 2 in canine myocardium. J Biol Chem 1985;260:7295-7303.
8. 2. J Biol Chem 1991;266:14526-14534.
9. 2 is modulated by ATP: concordant ATP-induced alteration in enzyme kinetics and mechanism-based inhibition. Biochem J 1991;280:581-587.
10. 2 from transplant recipients suffering end-stage ischemic heart disease. Circ Res 1992;70:486-495.
11. 2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet β-cells. Biochemistry 1993;32:327-336.
12. 2 activities in canine vascular smooth muscle. Biochim Biophys Acta 1992;1165:167-176.
13. 2: implications for the coordinated regulation of phospholipolysis and glycolysis. J Biol Chem 1993;268:9892-9900.
14. 2 during rabbit myocardial ischemia which is highly selective for plasmalogen substrate. J Biol Chem 1991;269:5629-5633.
15. 2 during myocardial ischemia. J Clin Invest 1991;88:331-335.
16. 2. J Biol Chem 1991;266:7227-7232.
17. 2 inhibitors. J Med Chem 1991;34:2260-2267.
18. + channels in cardiac myocytes by free fatty acids. Circ Res 1990;67:1040-1046.
19. Turk J, Gross RW, Ramanadham S. Perspective in diabetes: amplification of insulin secretion by lipid messengers. Diabetes 1993;42:367-374.
20. Han X, Zupan LA, Hazen SL, Gross RW. Semisynthesis and purification of homogeneous plasmenylcholine molecular species. Analyt Biochem 1992;200:119-124.
21. Hamm CW, Opie LH. Protective effects of verapamil, nifedipine and diltiazem in the coronary ligated, isolated working heart. Circ Res 1993;52(suppl 1):129-138.
22. Wroblewski F, La Due JS. Lactic dehydrogenase activity in blood. Proc Exp Biol Med 1955;90:210-213.
23. Van der Laarse A, Holaar L, Van der Volk LJM. Release of alpha hydroxybutarate from neonatal rat heart cell cultures exposed to anoxia and reoxygenation: comparison with impairment of structure and function of damaged cardiac cells. Cardiovasc Res 1979;13:345-353.
24. Grover GJ, McCullough JR, Henry DE, Conder ML, Sleph PG. Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide. J Pharmacol Exp Ther 1989;251:98-104.
25. McCullough JR, Normandin DE, Conder ML, Sleph PG, Dzwonczyk S, Grover GJ. Specific block of the anti-ischemic actions of cromakalim by sodium 5-hydroxydecanoate. Circ Res 1991;69:949-958.
26. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analyt Biochem 1976;72:248-253.
27. 2. J Biol Chem 1990;265:10622-10630.
28. 2 activity in ischemic and non-ischemic cardiac tissue. (Submitted for publication).
29. 2 in cell damage. Arch Biochem Biophys 1993;301:119-128.
30. Ramanadham S, Gross RW, Han X, Turk J. Inhibition of arachidonate release by secretagogue-stimulated pancreatic islets suppresses both insulin secretion and the rise in β-cell cytosolic calcium ion concentration. Biochemistry 1993;32:337-346.
31. Sargent CA, Smith MA, Dzwonczyk S, Sleph PG, Grover GJ. Effect of potassium channel blockade on the anti-ischemic actions of mechanistically diverse agents. J Pharmacol Exp Ther 1991;259:97-103.
32. Grover GJ, Dzwonczyk S, Sleph PG. Ruthenium red improves post-ischemic contractile function in isolated rat hearts. J Cardiovasc Pharmacol 1990;16:783-789.
33. + channels in insulinoma cells are activated by nonesterified fatty acids. Biochemistry 1992;31:4656-4661.
34. 2. J Biol Chem 1995;270:2885-2888.