Different mechanisms involved in relaxation of guinea-pig trachea by endothelin-1 and -3

European Journal of Pharmacology

Volumn 298, Issue 2, 1996, Pages 145-148

  Hadj Kaddour, Kamel ^a   Michel, Alain ^a   Chevillard, Claude ^b  

^a UNIV MONTPELLIER   (France)

^b INSERM   (France)

Author keywords

Charybdotoxin; Endothelin; Guinea pig; Nitric oxide (NO); Smooth muscle relaxation; Trachea

Indexed keywords

CARBACHOL; CHARYBDOTOXIN; ENDOTHELIN 1; ENDOTHELIN 3; HEMOGLOBIN; METHYLENE BLUE; NITRIC OXIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GUINEA PIG; MALE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION; TRACHEA MUCOSA; TRACHEA MUSCLE;

EID: 0029972426     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00760-1     Document Type: Article

References (12)

1. B receptor subtypes, J. Cardiovasc. Pharmacol. 22 (Suppl. 8), S219.
2. Battistini, B., T.D. Warner, A. Fournier and J.R. Vane, 1994, Characterization of ETB receptors mediating contractions induced by endothelin-1 or IRL 1620 in guinea-pig isolated airways: effects of BQ-123, FR139317 or PD 145065, Br. J. Pharmacol. 111, 1009.
3. Cardell, L.O., R. Uddman and L. Edvinsson, 1992, Evidence for multiple endothelin receptors in the guinea-pig pulmonary artery and trachea, Br. J. Pharmacol. 105, 376.
4. Filep, J.G., B. Battistini and P. Sirois, 1993, Induction by endothelin-1 of epithelium-dependent relaxation of guinea-pig trachea in vitro: role for nitric oxide, Br. J. Pharmacol. 109, 637.
5. B receptors and multiple signal transduction systems, Br. J. Pharmacol. 110, 435.
6. Hori, M., S.A. Sudjarwo, K. Oda, Y. Urade and H. Karaki, 1994, Two types of endothelin B receptor mediating relaxation in guinea-pig ileum, Life Sci. 54, 645.
7. +-channel in smooth muscle cells of porcine coronary artery, Eur. J. Pharmacol. 194, 31.
8. Miasiro, N., C.R. Nakaie and A.C.M. Paiva, 1993, Endothelin (16-21): biphasic effect and no desensitisation on the guinea-pig ileum, Br. J. Pharmacol. 109, 68.
9. Ninomiya, H., X.Y. Yu, Y. Uchida, S. Hasegawa and E.W. Spannhake, 1995, Specific binding of endothelin-1 to canine tracheal epithelial cells in culture, Am. J. Physiol. 268, L424.
10. Tschirhart, E., N. Frossard, C. Bertrand and Y. Landry, 1987, Arachidonic acid metabolites and airway epithelium-dependent relaxant factor, J. Pharmacol. Exp. Ther. 243, 310.
11. Uchida, Y., M. Saotome, A. Nomura, H. Ninomiya, H. Oshe, F. Hirata and S. Hasegawa, 1991, Endothelin-1 induced relaxation of guinea-pig trachealis muscles, J. Cardiovasc. Pharmacol. 17 (Suppl. 7), S210.
12. White, S.R., D.P. Hathaway, J.G. Umans, J. Tallet, C. Abrahams and A.R. Leff, 1991, Epithelial modulation of airway smooth muscle response to endothelin-1, Am. Rev. Respir. Dis. 144, 373.