The predicted amino acid sequence of the Salmonella typhimurium virulence gene mviA+ strongly indicates that MviA is a regulator protein of a previously unknown S. typhimurium response regulator family

Infection and Immunity

Volumn 64, Issue 6, 1996, Pages 2365-2367

  Benjamin Jr , William H ^a,b   Wu, Xinping ^b   Swords, W Edward ^b  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; REGULATOR PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL VIRULENCE; ESCHERICHIA COLI; GENE MUTATION; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; REGULATOR GENE; SALMONELLA TYPHI; SALMONELLA TYPHIMURIUM; SEQUENCE HOMOLOGY;

ALLELES; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BASE SEQUENCE; CONSERVED SEQUENCE; GENES, BACTERIAL; MOLECULAR SEQUENCE DATA; MUTATION; SALMONELLA TYPHIMURIUM; VIRULENCE;

EID: 0029972111     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.6.2365-2367.1996     Document Type: Article

References (23)

1. Albright, L. M., E. Huala, and F. M. Ausubel. 1989. Prokaryotic signal transduction mediated by sensor and regulator protein pairs. Annu. Rev. Genet. 23:311-336.
2. Alexeyev, M. F. 1995. Three kanamycin resistance gene cassettes with different polylinkers. BioTechniques 18:52-55.
3. Aricó, B., V. Scarlato, D. M. Monack, S. Falkow, and R. Rappuoli. 1991. Structural and genetic analysis of the bvg locus in Bordetella species. Mol. Microbiol. 5:2481-2491.
4. Benjamin, W. H., Jr., C. L. Turnbough, Jr., J. D. Goguen, B. S. Posey, and D. E. Briles. 1986. Genetic mapping of novel virulence determinants of Salmonella typhimurium to the region between trpD and supD. Microb. Pathog. 1:115-124.
5. s/s genotype of the mouse. Infect. Immun. 51:872-878.
6. r mice: functional mviA results in avirulence; mutant (nonfunctional) mviA results in virulence. J. Exp. Med. 174:1073-1083.
7. Bösl, M., and H. Kersten. 1994. Organization and functions of genes in the upstream region of tyrT of Escherichia coli: phenotypes of mutants with partial deletions of a new gene (tgs). J. Bacteriol. 176:221-231.
8. Bösl, M. R. 1993. Genetic map of the tyrT region of Escherichia coli from 27.1 to 27.7 minutes based exclusively on sequence data. J. Bacteriol. 175:7751-7753.
9. Cozzone, A. 1993. ATP-dependent protein kinases in bacteria. J. Cell. Biochem 51:7-13.
10. Dahl, M. K., T. Msadek, F. Kunst, and G. Rapoport. 1991. Mutational analysis of the Bacillus subtilis DegU regulator and its phosphorylation by the DegS protein kinase. J. Bacteriol. 173:2539-2547.
11. Dorman, C. J, S. Chalfield, C. F. Higgins, C. Hayward, and G. Dougan. 1989. Characterization of porin and ompR mutants of a virulent strain of Salmonella typhimurium: ompR mutants are attenuated in vivo. Infect. Immun. 57:2136-2140.
12. Dziejman, M., and J. J. Mekalanos. 1995. Two-component signal transduction and its role in the expression of bacterial virulence factors, p. 305-317. In J. A. Hoch and T. J. Silhavy (ed.), Two-component signal transduction. ASM Press, Washington, D.C.
13. Fields, P. I., E. A. Groisman, and F. Heffron. 1989. A Salmonella locus that controls resistance to microbiocidal proteins from phagocytic cells. Science 243:1059-1062.
14. Gay, N. J. 1984. Construction and characterization of an Escherichia coli strain with a und mutation. J. Bacteriol. 158:820-825.
15. Groisman, E. A., E. Chiao, C. J. Lipps, and F. Heffron. 1989. Salmonella typhimurium phoP virulence gene is a transcriptional regulator. Proc. Natl. Acad. Sci. USA 86:7077-7081.
16. Harr, R., M. Häggström, and P. Gustafsson. 1983. Search algorithm for pattern match analysis of nucleic acid sequences. Nucleic Acids Res. 11: 2943-2957.
17. Mekalanos, J. J. 1992. Environmental signals controlling expression of virulence determinants in bacteria. J. Bacteriol. 174:1-7.
18. Parkinson, J. S., and E. C. Kofoid. 1992. Communication modules in bacterial signaling proteins. Annu. Rev. Genet. 26:71-112.
19. Pazour, G. J., C. N. Ta, and A. Das. 1992. Constitutive mutations of Agrobacterium tumefaciens transcriptional activator virG. J. Bacteriol. 174:4169-4174.
20. Stibitz, S., A. A. Weiss, and S. Falkow. 1988. Genetic analysis of a region of the Bordetella pertussis chromosome encoding filamentous hemagglutinin and the pleiotropic regulatory locus vir. J. Bacteriol. 170:2904-2913.
21. Stock, J. B., A. J. Ninfa, and A. M. Stock. 1989. Protein phosphorylation and regulation of adaptive responses in bacteria. Microbiol. Rev. 53:450-490.
22. Stock, J. B., A. M. Stock, and J. M. Mottonen. 1990. Signal transduction in bacteria. Nature (London) 344:395-400.
23. Zubay, G. 1973. In vitro synthesis of protein in microbial systems. Annu. Rev. Genet. 7:267-287.