Dynamic modelling of the binding of substances to the conserved membrane-adjacent heptapeptide of the 15-residue C-terminal cytoplasmic fragment of mammalian dopamine D2 receptors

Neurochemical Research

Volumn 21, Issue 2, 1996, Pages 177-200

  Roberts, Eugene ^a   Wendel, John ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Dopamine D2 receptor; Dynamic modelling; G protein

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; CARNOSINE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR STIMULATING AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN; HOMOCARNOSINE; MUSCIMOL;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATTLE; DYNAMICS; FROG; HUMAN; MAMMAL; MEMBRANE BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RECEPTOR BLOCKING; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANIMALS; COMPUTER SIMULATION; CONSERVED SEQUENCE; CYTOPLASM; DOPAMINE; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; ELECTROSTATICS; FLUOXETINE; MAMMALS; MEMBRANES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; RECEPTORS, DOPAMINE D2;

ANURA; BOS TAURUS; MAMMALIA;

EID: 0029971964     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02529135     Document Type: Article

References (42)

1. Niznik, H. B. (ed.). 1994. Dopamine Receptors and Transporters, 677 pp Marcel Dekker, Inc., New York.
2. Gingrich, J. A., and Caron, M. G. 1993. Recent advances in the molecular biology of dopamine receptors. Annu. Rev. Neurosci. 16:299-321.
3. O'Dowd, B. F. 1993. Structures of dopamine receptors. J. Neurochem. 60:804-816.
4. Civelli, O., Bunzow, J. R., and Grandy, D. K. 1993. Molecular diversity of the dopamine receptors. Annu. Rev. Pharmacol. Toxicol. 33:281-307.
5. Fryxell, K. J. 1994. The evolution of the dopamine receptor gene family. Pages 237-263 in Niznik, H. B. (ed.). Dopamine Receptors and Transporters, Marcell Dekker, Inc., New York.
6. 2-adrenergic receptor. 1988. J. Biol. Chem. 263:15985-15992.
7. 2-adrenergic receptor. J. Biol. Chem. 264:7564-7569.
8. 2-adrenergic receptor in Sf9 cells. J. Biol. Chem. 267:21733-21737.
9. L dopamine receptor in Sf9 cells. J. Neurochem. 63:1589-1595.
10. 1 receptor. Eur. J. Pharmacol. 267:7-19.
11. Donnelly, D., and Findlay, J. B. C. 1994. Seven-helix receptors: structure and modelling. Current Opinion in Structural Biology 4: 582-589.
12. 2 receptor. Proc. Natl. Acad. Sci. U.S.A. 88:8111-8115.
13. Hibert, M. F., Trumpp-Kallmeyer, S., Bruinvels, A., and Hoflack, J. 1991. Three-dimensional models of neurotransmitter G-binding protein-coupled receptors. Molec. Pharmacol. 40:8-15.
14. Mansour, A., Meng, F., Meador-Woodruff, J. H., Taylor, L. P., Civelli, O., and Akil, H. 1992. Site-directed mutagenesis of the human dopamine D2 receptor. Eur. J. Pharmacol. 227:205-214.
15. Tomic, M., Seeman, P., George, S. R., O'Dowd, B. F. 1993. Dopamine D1 receptor mutagenesis: Role of amino acids in agonist and antagonist binding. 1993. Biochem. Biophys. Res. Commun. 191:1020-1027.
16. Hutchins, C. 1994. Three-dimensional models of the D1 and D2 dopamine receptors. Endocrine J. 2:7-23.
17. Seeman, P., and Van Tol, H. H. M. 1994. Dopamine receptor pharmacology. TIPS 15:264-270.
18. Biograf Reference Manual, Version 3.2.1.1993. Marketed by Molecular Simulations, Inc., 16 New England Executive Park, Burlington, MA 01803-5297.
19. Mayo, S. L., Olafson, B. D., and Goddard, W. A. III. 1990. Dreiding: A generic force field for molecular simulations. J. Phys. Chem. 94:8897-8909.
20. Rappe, A. K., and Goddard, W. A. III. 1991. Charge equilibration for molecular dynamics simulation. J. Phys. Chem. 95:3358-3363.
21. McGeer, E. G., McGeer, P. L., and McLennan, H. 1961. The inhibitory action of 3-hydroxytyramine, gamma-aminobutyric acid (GABA) and some other compounds towards the crayfish stretch receptor neuron. J. Neurochem. 8:36-49.
22. Asin, K. E. and Bednarz, L. M. 1990. Behavioral interactions between muscimol and compounds selective for the D1 and D2 dopamine receptor subtypes. Neurosci. Lett. 113:286-291.
23. Kalivas, P. W., Duffy, P., and Eberhardt, H. 1990. Modulation of AlO dopamine neurons by γ-aminobutyric acid agonists. J. Pharmacol. Exp. Ther. 253:858-865.
24. B-receptor activation alters the firing pattern of dopamine neurons in the rat substantia nigra. Synapse 15:229-238.
25. B, receptors in vitro. Brain Res. 659:133-137.
26. i. Neurosci. Lett. 112:205-209.
27. 2 receptors in rat substantia nigra neurones. J. Physiol., 401:437-453.
28. Argiolas, A., Fadda, F., Melis, M. R., Marcou, M., Porceddu, M. L. and Gessa, G. L. 1982. Delayed inhibition of dopamine synthesis by γ-butyrolactone and baclofen: dopamine autoreceptor supersensitivity? Eur. J. Pharmacol. 85:23-27.
29. Herrera-Marschitz, M. and Ungerstedt, U. 1987. The dopamine-γ aminobutyric acid interaction in the striatum of the rat is differently regulated by dopamine D-1 and D-2 types of receptor: evidence obtained with rotational behavioural experiments. Acta Physiol. Scand. 129:371-380.
30. B Receptors in Mammalian Function, John Wiley & Sons Ltd., Chichester, England.
31. B receptor pharmacology. Annu. Rev. Pharmacol. Toxicol. 33:109-47.
32. Bowery, N. G. 1982. Baclofen: 10 years on. TIPS, 3:400-403.
33. Roberts, E. 1986. GABA: The road to neurotransmitter status, in Olsen, R. W. and Venter, J. C. (eds.), Benzodiazepine/GABA Receptors and Chloride Channels: Structural and Functional Properties, Alan R. Liss, Inc., New York.
34. Krause, D. N., Ikeda, K., and Roberts, E. 1981. Dose-conductance relationships for GABA agonists and the effect of uptake inhibitors in crayfish stretch receptor neurons. Brain Res. 225:319-332.
35. Muhyaddin, M., Roberts, P. J., and Woodruff, G. N. 1982. Presynaptic γ-aminobutyric acid receptors in the rat anococcygeus muscle and their antagonism by 5-aminovaleric acid. Br. J. Pharm. 77:163-168.
36. Desarmenien, M., Feltz, P., Headley, P. M., and Santangelo, F. 1981. SL 75 102 as a γ-aminobutyric acid agonist: experiments on dorsal root ganglion neurones in vitro. Br. J. Pharm. 72:355-364.
37. B antagonists. Pharmacol. Commun. 2:52-56.
38. B receptor antagonists: from synthesis to therapeutic applications. TIPS 14:391-394.
39. Crush, K. G. 1970. Carnosine and related substances in animal tissues. Comp. Biochem. Physiol. 34:3-30.
40. Boldyrev, A. A., Dupin, A. M., Pindel, E. V., and Severin, S. E. 1988. Antioxidative properties of histidine-containing dipeptides from skeletal muscles of vertebrates. Comp. Biochem. Physiol. 893:245-250.
41. Kohen, R., Yamamoto, Y., Cundy, K. C., and Ames, B. N. 1988. Antioxidant activity of carnosine, homocamosine, and anserine present in muscle and brain. Proc. Natl. Acad. Sci. USA 85:3175-3179.
42. Roberts, E. 1990. Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) as neural facilitators: effects on brain tissue in culture and on memory in young and old mice. A cyclic GMP hypothesis of action of DHEA and DHEAS in nervous system and other tissues, pages 13-42 in Kalimi, M. and Regelson, W. (eds.), The Biological Role of Dehydroepiandrosterone (DHEA), Walter de Gruyter & Co, Berlin-New York.