Investigation of on-line reversed-phase liquid chromatography-gas chromatography-mass spectrometry as a tool for the identification of impurities in drug substances

Analyst

Volumn 121, Issue 1, 1996, Pages 61-66

  Goosens, Elise C ^a   Stegman, Karel H ^a   De Jong, Dirk ^a   De Jong, Gerhardus J ^a   Brinkman, Udo A Th ^b  

^a Solvay Pharmaceuticals Inc   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Drug substance; Gas chromatography mass spectrometry; Impurity profiling; Reversed phase liquid chromatography

Indexed keywords

ACETONITRILE; MEBEVERINE; MESYLIC ACID;

ANALYTIC METHOD; ANION EXCHANGE; ARTICLE; CONTROLLED STUDY; DRUG IMPURITY; DRUG ISOLATION; GAS CHROMATOGRAPHY; MASS SPECTROMETER; MASS SPECTROMETRY; REVERSED PHASE LIQUID CHROMATOGRAPHY;

EID: 0029971392     PISSN: 00032654     EISSN: None     Source Type: Journal    
DOI: 10.1039/an9962100061     Document Type: Article

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