Effects of somatostatin on luminal transit and absorption of nutrients in the proximal gut of minipigs

Digestive Diseases and Sciences

Volumn 41, Issue 5, 1996, Pages 894-901

  Eisenbraun, Jürgen ^a   Ehrlein, Hans Jörg ^a  

^a UNIVERSITY OF HOHENHEIM   (Germany)

Author keywords

absorption; nutrients; somatostatin; transit

Indexed keywords

SODIUM CHLORIDE; SOMATOSTATIN;

AMINO ACID ABSORPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOHYDRATE ABSORPTION; CONTROLLED STUDY; FEMALE; GASTROINTESTINAL TRANSIT; INTRAVENOUS DRUG ADMINISTRATION; LIPID ABSORPTION; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANALYSIS OF VARIANCE; ANIMALS; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GASTROINTESTINAL TRANSIT; HORMONE ANTAGONISTS; INTESTINAL ABSORPTION; JEJUNUM; LINEAR MODELS; SOMATOSTATIN; SWINE; SWINE, MINIATURE; TIME FACTORS;

EID: 0029971374     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02091528     Document Type: Article

References (36)

1. Johansson C, Wisen O, Efendic S, Uvnäs-Wallensten K: Effects of somatostatin on gastrointestinal propagation and absorption of oral glucose in man. Digestion 22:126-137, 1981
2. Krejs GJ: Effect of somatostatin and atropine infusion on intestinal transit time and fructose absorption in the perfused human jejunum. Diabetes 33:548-551, 1984
3. Meier RF, Gyr KE: Somatostatin: Characterization and the role of analogues. Dig Surg 11:433-437, 1994
4. Hürlimann S: Role of somatostatin and octreotide in esophageal varices, dumping syndrome and diarrhea. Dig Surg 11:438-444, 1994
5. Sjöqvist A: Difference between the antisecretory mechanisms of opioids and the somatostatin analogue octreotide in cholera toxin-induced small intestinal secretion in the rat. Regul Pept 40:339-349, 1992
6. Botella A, Vabre F, Fioramonti J, Thomas F, Bueno L: In vivo inhibitory effect of Ianreotide (BIM 23014), a new somatostatin analog, on prostaglandin- and cholera toxin-stimulated intestinal fluid in the rat. Peptides 14:297-301, 1993
7. Bratusch-Marrain P, Vierhapper H, Grubeck-Loebenstein B, Waldhäusl W, Nowotny P: Antidiabetic action of somatostatin after oral glucose loading: Due to suppression of glucagon and growth hormone or of intestinal carbohydrate absorption? Horm Metab Res 13:305-309, 1981
8. Wahren J, Felig P: Influence of somatostatin on carbohydrate disposal and absorption in diabetes mellitus. Lancet 2:1213-1216, 1976
9. Moller N, Petrany G, Cassidy D, Sheldon WL, Johnston DG, Laker MF: Effects of the somatostatin analogue SMS 201-995 (sandostatin) on mouth-to-caecum transit time and absorption of fat and carbohydrate in normal man. Clin Sci 75:345-350, 1988
10. Candrina R, Giustina G: Effect of a new long-acting somatostatin analogue (SMS 201-995) on glycemic and hormonal profiles in insulin-treated type Il diabetic patients. J Endocrinol Invest 11:501-507, 1988
11. Ladefoged K, Christensen KC, Hegnhoj J, Jarnum S: Effect of a long acting somatostatin analogue SMS 201-995 on jejunostomy effluents in patients with severe short bowel syndrome. Gut 30:943-949, 1989
12. Nightingale JMD, Lennard-Jones JE, Walker E, Farthing MJG: Jejunal efflux in short bowel syndrome. Lancet 336:765-768, 1990
13. Tulassay Z, Tulassay T, Gupta R, Cierny G: Long acting somatostatin analogue in dumping syndrome. Br J Surg 76:1294-1295, 1989
14. Primrose JN, Johnston D: Somatostatin-analogue SMS-201-995 (octreotide) as a possible solution to the dumping. Br J Surg 76:140-145, 1989
15. Gray JL, Debas HT, Mulvihill SJ: Control of dumping symptoms by somatostatin analogue in patients after gastric surgery. Arch Surg 126:1231-1236, 1991
16. Richards WO, Geer R, O'Dorisio TM, Robarts T, Parish KL, Rice D, Woltering G, Abumrad NN: Octreotide acetate induces fasting small bowel motility in patients with dumping syndrome. J Surg Res 49:483-487, 1990
17. Battershill PE, Clissold SP: Octreotide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in conditions associated with excessive peptide secretion. Drugs 38:658-702, 1989
18. Cascinu S, Fedeli A, Fedeli SL, Catalano G: Octreotide versus loperamide in the treatment of fluorouracil-induced diarrhea: A randomized trial. J Clin Oncol 11:148-151, 1993
19. Farthing MJG: Octreotide in the treatment of refractory diarrhoea and intestinal fistulae. Gut 35 (suppl 3):S5-S10, 1994
20. Krejs GJ, Browne R, Raskin P: Effect of intravenous somatostatin on jejunal absorption of glucose, amino acids, water and electrolytes. Gastroenterology 78:26-31, 1980
21. Sorribas V, Arruebo P, Murillo D, Alcalde AI, Effect of somatostatin on d-galactose transport across the small intestine of rats. Comp Biochem Physiol (A) 86:63-66, 1987
22. Schwarz J-M, Acheson KJ, Tappy L, Piolino V, Müller MJ, Felber JP, Jequier E: Thermogenesis and fructose metabolism in humans. Am J Physiol (Endocrinol Metab) 262:E591-E598, 1992
23. Wagner H, Hengst K, Jansen H, Gerlach U: Effects of somatostatin on absorption of mono- and disaccharides in small intestine in vivo and in vitro in man and rats. Metabolism 27 (suppl 1):1329-1332, 1978
24. Schusdziarra V, Harris V, Arimura A, Unger RH: Evidence for a role of splanchnic somatostatin in homeostasis of ingested nutrients. Endocrinology 104:1705-1708, 1979
25. Ho PJ, Boyajy LD, Greenstein E, Barkan AL: Effect of chronic Octreotide treatment on intestinal absorption in patients with acromegaly. Dig Dis Sci 38:309-315, 1993
26. Nightingale JM, Walker ER, Burnham WR, Farthing MJ, Lennard-Jones JE: Octreotide (a somatostatin analogue) improves the quality of life in some patients with a short intestine. Aliment Pharmacol Ther 3:367-373, 1989
27. Wilson FA, Antonson DL, Hart BL, Warr TA, Cherrington AD, Liljenquist JE: The effect of somatostatin on the intestinal transport of glucose in vivo and in vitro in the rat. Endocrinology 106:1562-1567, 1980
28. Märki F: Effect of somatostatin on intestinal absorption of nutrients in the rat. Regul Pept 2:371-381, 1981
29. Daumerie C, Henquin JC: Somatostatin and the intestinal transport of glucose and other nutrients in the anaesthetized rat. Gut 23:140-145, 1982
30. Daumerie C, Henquin JC: Evaluation of the effects of somatostatin on intestinal absorption of nutrients in rats. Diabetologia 19:268, 1980 (abstract)
31. Koerker DJ, Hansen BC: Influence of somatostatin on gastric motility and meal absorption in rhesus monkeys. Macaca mulatta. Metabolism 30:335-339, 1981
32. Huge A, Weber E, Ehrlein H-J: Effects of enteral feedback inhibition on motility, luminal flow, and absorption of nutrients in proximal gut of minipigs. Dig Dis Sci 40:1024-1034, 1995
33. Slater EE, Katzen HM, Nutt RF, Saperstein R, Steelman SL: The effects of somatostatin and selected analogs on lipid absorption in animals. Adv Exp Med Biol 188:355-368, 1985
34. Fioramonti J, Bueno L, Ruckebusch M: Blood sugar oscillations and duodenal migrating myoelectric complexes. Am J Physiol 242:G15-G20, 1982
35. Bueno L, Fioramonti J: Patterns of intestinal motility and their relationship with transit of digesta and absorption. In The Relationships between Intestinal Motility and Epithelial Transport. NW Read (ed). Janssen Research Council, 1986, pp 85-96
36. Rayner DV: The relationships between glucose absorption and insulin secretion and the migrating myoelectric complex in the pig. Exp Physiol 76:67-76, 1991