Cytokine inhibitors in autoimmune disease

Seminars in Arthritis and Rheumatism

Volumn 26, Issue 2, 1996, Pages 539-557

  Weckmann, A L ^a   Alcocer Varela, J ^a  

^a Inst Nacional Nutricion S Zubiran   (Mexico)

Author keywords

autoimmunity; Cytokine antagonists; IL 1ra; soluble TNF receptors

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 4; MONOCLONAL ANTIBODY; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

AUTOIMMUNITY; HUMAN; JUVENILE RHEUMATOID ARTHRITIS; OSTEOARTHRITIS; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SCLERODERMA;

EID: 0029970798     PISSN: 00490172     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-0172(96)80042-4     Document Type: Article

References (82)

1. Fernández-Botran R. Soluble cytokine receptors: Their role in immunoregulation FASEB J 5 1992 2567 2574
2. Duff G.W. Cytokines and anti-cytokines Br J Rheumatol 32 1993 15 20
3. Miossec P. Acting on the cytokine balance to control auto-immunity and chronic inflammation Eur Cytokine Netw 4 1993 245 251
4. Debets R. Savelkoul F.J. Cytokine antagonists and their potential therapeutic use Immunol Today 15 1994 455 458
5. Arend W.P. Dayer J.M. Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis Arthritis Rheum 33 1990 305 315
6. Dinarello C.A. Thompson R.C. Blocking IL-1: Interleukin 1 receptor antagonist in vivo and in vitro Immunol Today 12 1991 404 410
7. Larrick J.W. Native interleukin-1 inhibitors Immunol Today 10 1989 61 66
8. Dayer J.M. Fenner H. The role of cytokines and their inhibitors in arthritis Baillière's Clin Rheumatol 6 1992 485 516
9. Arend W.P. Joslin F.G. Massoni R.J. Effects of immune complexes on production by human monocytes of interleukin 1 or an interleukin 1 inhibitor J Immunol 134 1985 3868 3875
10. Seckinger P. Lowenthal J.W. Williamson K. A urine inhibitor of interleukin-1 activity that blocks ligand binding J Immunol 139 1987 1546 1549
11. Hannum C.H. Wilcox C.J. Arend W.P. Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor Nature 343 1990 336 340
12. Dinarello C.A. Interleukin-1 and interleukin-1 antagonism Blood 77 1991 1627 1652
13. Schur P.H. Chang D.M. Baptiste P. Human monocytes produce IL-1 and an inhibitor of IL-1 in response to two different signals Clin Immunol Immunopathol 57 1990 45 63
14. Carter D.B. Deibel M.R. Dunn C.J. Purification, cloning, expression, and biological characterization of an interleukin-1 receptor antagonist protein Nature 344 1990 633 638
15. Granowitz E.V. Clark B.D. Mancilla J. Interleukin-1kin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to type II interleukin-1 receptor J Biol Chem 266 1991 14147 14150
16. Dripps D.J. Brandhuber B.J. Thompson R.C. Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction J Biol Chem 266 1991 10331 10336
17. Eisenberg S.P. Evans R.J. Arend W.P. Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist Nature 343 1990 341 346
18. Eisenberg S.P. Brewer M.T. Verderber E. IL-1 receptor antagonist (IL-1ra) is a member of the IL-1 gene family: Evolution of a cytokine control mechanism Proc Natl Acad Sci U S A 88 1991 5232 5236
19. Arend W.P. Interleukin 1 receptor antagonist: A new member of the Interleukin 1 family J Clin Invest 88 1991 1445 1451
20. Firestein G.S. Berger A.E. Tracey D.E. IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium J Immunol 149 1992 1054 1062
21. Arend W.P. Interleukin-1 receptor antagonist Adv Immunol 54 1993 167 227
22. Henderson B. Therapeutic modulation of cytokines Ann Rheum Dis 54 1995 519 523
23. Haskill S. Marting G. Van Le L. cDNA cloning of an intracellular form of the human interleukin-1 receptor antagonist associated with epithelium Proc Natl Acad Sci U S A 88 1991 3681 3685
24. Biegler C.F. Norris D.A. Weston W.L. Interleukin-1 receptor antagonist production by human keratinocytes J Invest Dermatol 98 1992 34 44
25. Mazzei G.J. Bernasconi L. Lewis C. Human granulocyte-macrophage colony-stimulating factor plus phorbol myristate acetate stimulate a promyelocytic cell line to produce an IL-1 inhibitor J Immunol 20 1990 683 689
26. Chang D.M. Cellular signals for the induction of human interleukin-1 receptor antagonist Clin Immunol Immunopathol 74 1995 23 30
27. Arend W.P. Welgus H.G. Thompson R.C. Biological properties of recombinant human monocyte-derived interleukin-1 receptor antagonist J Clin Invest 85 1990 1694 1697
28. Thompson R.C. IL-1 receptor antagonist in arthritis and arthritis models Clin Exp Rheumatol 11 1993 S169
29. Schreuder H.A. Rondeau J.M. Tardif C. Refined crystal structure of the interleukin-1 receptor antagonist: Presence of a disulfide link and a cis-proline Eur J Biochem 227 1995 838 847
30. Blakemore A.I.F. McDonagh A.J.G. Messenger A.G. Genetics of interleukin 1 receptor antagonist in inflammatory skin diseases J Invest Dermatol 100 1993 522
31. Rosbotham J.L. Barker J.N. Trembath R.C. Exclusion of interleukin-1 receptor antagonist as a primary disease determinant for psoriasis (letter) J Invest Dermatol 104 1995 306
32. Deleuran B.W. Chu C.Q. Field M. Localization of interleukin 1α (IL-1α), type 1 IL-1 receptor and interleukin 1 receptor antagonist protein in the synovial membrane andcartilage/pannus junction in rheumatoid arthritis Br J Rheumatol 31 1992 801 809
33. Koch A.E. Kunkel S.L. Chensue S.W. Expression of Interleukin-1 and Interleukin-1 receptor antagonist by human rheumatoid synovial tissue macrophages Clin Immunol Immunopathol 65 1992 23 29
34. Roux-Lombard P. Modoux C. Vischer T. Inhibitors of interleukin 1 activity in synovial fluids and in cultured synovial fluid mononuclear cells J Rheumatol 19 1992 517 523
35. Malyak M. Swaney R.E. Arend W.P. Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies: Potential contribution from synovial fluid neutrophils Arthritis Rheum 36 1993 781 789
36. Firestein G.S. Boyle D.L. Yu C. Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis Arthritis Rheum 37 1994 644 652
37. Arend W.P. Smith M.F. Jr Janson R.W. IL-1 receptor antagonist and IL-1β production in human monocytes are regulated differently J Immunol 147 1991 1530 1536
38. Poutsiaka D.D. Clark B.D. Vannier E. Production of interleukin-1 receptor antagonist and interleukin-1β by peripheral blood mononuclear cells is differentially regulated Blood 78 1991 1275 1281
39. Sandborg C.I. Berman M.A. Andrews B.S. Increased production of an interleukin-1 inhibitor with fibroblast stimulating activity by mononuclear cells from patients with scleroderma Clin Exp Immunol 66 1986 312 319
40. Prieur A.M. Kaufmann M.T. Griscelli C. Specific interleukin-1 inhibitor in serum and urine of children with systemic juvenile chronic arthritis Lancet 2 1987 1240 1242
41. Peritt D. Flechner I. Yanai P. The M20 IL-1 inhibitor. II. Biological characterization J Immunol Methods 155 1992 167 174
42. Fibach E. Rigel M. Peled T. The effect of human myelomonocytic leukemic cell line (M20) derived IL-1 inhibitor on human erythroid cell development Leuk Lymphoma 15 1994 327 332
43. Barak V. Peritt D. Yanai P. In vivo anti inflammatory effects of the M20 IL-1 inhibitor: I. Effects on acute inflammatory parameters Biotherapy 6 1993 263 270
44. Barak V. Gorodetsky R. Weidenfeld J. In vivo anti-inflammatory effects of the M20 IL-1 inhibitor: II. Effects on serum reactants Biotherapy 6 1993 271 277
45. Cope A. Aderka D. Doherty M. Soluble tumour necrosis factor (TNF) receptors are increased in the sera and synovial fluids of patients with rheumatic diseases Arthritis Rheum 35 1992 1160 1169
46. Dower S.K. Wignall J.M. Schooley K. Retention of ligand binding activity by the extracellular domain of the IL-1 receptor J Immunol 142 1989 4314
47. Arend W.P. Malyak M. Smith M.F. Jr Binding of IL-1α, IL-1β, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids J Immunol 153 1994 4766 4774
48. Spriggs M.K. Hruby D.E. Maliszewski C.R. Vaccinia and cowpox viruses encode a novel secreted interleukin-1 binding protein Cell 71 1992 145
49. Ray C.A. Black R.A. Kronheim S.R. Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1α converting enzyme Cell 69 1992 597 604
50. Lambert C. Brealey R. Steele J. The interaction of Tamm-Horsfall protein with the extracellular matrix Immunology 79 1993 203 210
51. Buchan G. Barret K. Turner M. Interleukin-1 and tumor necrosis factor mRNA expression in rheumatoid arthritis: Prolonged production of IL-1α Clin Exp Immunol 73 1988 499
52. Santis A.G. Campanero M.R. Alonso J.L. Regulation of tumor necrosis factor (TNF)-α synthesis and TNF receptors expression in T lymphocytes through the CD2 activation pathway Eur J Immunol 22 1992 3155 3160
53. Seckinger P. Zhang J.H. Hauptmann B. Characterization of a tumor necrosis factor alpha inhibitor: Evidence of immunological cross-reactivity with the TNF receptor Proc Natl Acad Sci U S A 87 1990 5188 5192
54. Brennan F.M. Gibbons D.L. Mitchell T. Enhanced expression of TNF receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints Eur J Immunol 22 1992 1907 1912
55. Heilig B. Fiehn C. Brockhaus M. Evaluation of soluble tumor necrosis factor (TNF) receptors and TNF receptor antibodies in patients with systemic lupus erythematosus, progressive systemic sclerosis, and mixed connective tissue disease J Clin Immunol 13 1993 321 328
56. Aderka D. Wysenbeek A. Engelmann H. Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus Arthritis Rheum 36 1993 1111 1120
57. Fenner H. Strategies for the clinical development of anti-cytokines Clin Exp Rheumatol 11 1993 S183 S184
58. Maini R.N. Brennan F.M. Williams R. TNFα in rheumatoid arthritis and prospects of anti-TNF therapy Clin Exp Rheumatol 11 suppl 8 1993 S173 S175
59. Sheehan K.C.K. Ruddle N.H. Schreiber R.D. Generation and characterization of hamster monoclonal antibodies that neutralize murine tumour necrosis factors J Immunol 142 1989 3884 3893
60. Williams R.O. Feldmann M. Maini R.N. Anti-tumour necrosis factor ameliorates joint disease in murine collagen-induced arthritis Proc Natl Acad Sci U S A 89 1992 9784 9788
61. Keffer J. Probert L. Cazlaris H. Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis EMBO J 10 1991 4025 4031
62. Elliott M.J. Maini R.N. Feldmann M. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α Arthritis Rheum 36 1993 1681 1690
63. Elliott M.J. Maini R.N. Feldmann M. Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis Lancet 344 1994 1105 1110
64. Elliott M.J. Maini R.N. Feldmann M. Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis Lancet 344 1994 1125 1127
65. Maini R.N. Elliott M.J. Brennan F.M. Beneficial effects of tumour necrosis factor-alpha (TNF-a) blockade in rheumatoid arthritis Clin Exp Immunol 101 1995 207 212
66. Cope A.P. Londei M. Chu N.R. Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex: Reversal invivo by anti-TNF antibodies in patients with rheumatoid arthritis J Clin Invest 94 1994 749 760
67. Suitters A.J. Foulkes R. Opal S.M. Differential effect of isotype on efficacy of anti-tumor necrosis factor alpha chimeric antibodies in experimental septic shock J Exp Med 179 1994 849 856
68. Alvaro-Gracia J.M. Zvaifler N.J. Firestein G.S. Cytokines in chronic inflammatory arthritis. V. Mutual antagonism between IFN-gamma and TNF-alpha on HLA-DR expression, proliferation, collagenase production and GMCSF production by rheumatoid arthritis synoviocytes J Clin Invest 86 1990 1790 1798
69. Cannon G.W. Emkey R.D. Denes A. Prospective two-year follow-up of recombinant interferon-gamma in rheumatoid arthritis J Rheumatol 17 1990 304 310
70. Tilg H. Mier J.M. Vogel W. Induction of circulating IL-1 receptor antagonist by IFN treatment J Immunol 150 1993 4687 4692
71. Orino E. Sone S. Nii A. IL-4 up-regulates IL-1 receptor antagonist gene expression and its production in human blood monocytes J Immunol 149 1992 925 931
72. Vannier E. Miller L.C. Dinarello C.A. Coordinated antiinflammatory effects of interleukin 4: Interleukin 4 supresses interleukin 1 production but up regulates gene expression and synthesis of interleukin 1 receptor antagonist Proc Natl Acad Sci USA 89 1992 4076 4080
73. Kuruvilla A.P. Shah R. Hochwald G.M. Protective effect of transforming growth factor 01 on experimental autoimmune diseases in mice Proc Natl Acad Sci U S A 88 1991 2918 2921
74. Turner M. Chantry D. Katsikis P. Induction of the interleukin 1 receptor antagonist protein by transforming growth factor-beta Eur J Immunol 21 1991 1635 1639
75. Dubois C.M. Ruscetti F.W. Palaszynski E.W. Transforming growth factor 0 is a potent inhibitor of interleukin 1 (IL-1) receptor expression: Proposed mechanism of inhibition of IL-1 action J Exp Med 172 1990 737 744
76. Brennan F.M. Feldmann M. Cytokines in autoimmunity Curr Opin Immunol 4 1992 754 759
77. de Waal Malefyt R. Abrams J. Bennet B. Interleukin-10 inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes J Exp Med 174 1991 1209 1220
78. Llorente L. Richaud-Patin Y. Fior R. In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus: A potential mechanism of B lymphocyte hyperactivity and autoimmunity Arthritis Rheum 37 1994 1647 1655
79. Katsikis P.D. Chu C.O. Brennan F.M. Immunoregulatory role of interleukin 10 in rheumatoid arthritis J Exp Med 179 1994 1517 1527
80. Tilg H. Trehu E. Atkins M.B. Interleukin-6 (IL-6) as an anti-inflammatory cytokine-induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factorreceptor-p55 Blood 83 1994 113 118
81. Tilg H. Shapiro L. Vannier E.D. Induction of circulating antagonists to IL-1 and TNF by IL-1 administration and their effects on IL-2-induced cytokine production in vitro J Immunol 152 1994 3189 3198
82. Sewell K.L. Parker K.C. Woodworth T.G. DAB486IL-2 fusion toxin in refractory rheumatoid arthritis Arthritis Rheum 36 1993 1223 1233