Prevention of cardiac hypertrophy by a sub-antihypertensive dose of the α1-adrenergic antagonist bunazosin in Dahl salt-sensitive rats

Hypertension Research

Volumn 19, Issue 3, 1996, Pages 147-150

  Izumi, Yoichi ^a   Matsuoka, Masako ^a   Kubo, Atsusi ^a   Nakayama, Tomohiro ^a   Fukuda, Noboru ^a   Watanabe, Yoshiyasu ^a   Soma, Masayoshi ^a   Kanmatsuse, Katsuo ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

Bunazosin; Cardiac hypertrophy; Dahl salt sensitive rat; 1 adrenergic receptor

Indexed keywords

ALDOSTERONE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ATRIAL NATRIURETIC FACTOR; BUNAZOSIN; METADRENALIN; NORMETADRENALIN; RENIN; SODIUM CHLORIDE;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; BODY WEIGHT; CONTROLLED STUDY; DNA CONTENT; GLOMERULUS FILTRATION RATE; HEART LEFT VENTRICLE MASS; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; INTRAGASTRIC DRUG ADMINISTRATION; MALE; NONHUMAN; PATHOGENESIS; PLASMA RENIN ACTIVITY; PULSE RATE; RAT; SODIUM EXCRETION; URINE VOLUME;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BLOOD PRESSURE; CARDIOMEGALY; HYPERTENSION; MALE; QUINAZOLINES; RATS; SODIUM CHLORIDE;

EID: 0029970765     PISSN: 09169636     EISSN: None     Source Type: Journal    
DOI: 10.1291/hypres.19.147     Document Type: Article

References (27)

1. Swynghedauw B, Delcayre C: Biology of cardiac overload. Pathobiol Ann 1982; 12: 137-183.
2. Tarazi RC, Levy MN: Cardiac response in increased afterload: State-of-the-art review. Hypertension 1982; 4 (Suppl): 8-18.
3. Fröhlich ED, Tarazi RC: Is arterial pressure the sole factor responsible for hypertensive heart hypertrophy? Am J Cardiol 1976; 44: 956-963.
4. Morgan HE, Baker KM: Cardiac hypertrophy: Mechanical, neural and endocrine dependence. Circulation 1991; 83: 13-25.
5. Sen S, Tarazi RC, Khairallah PA, et al: Cardiac hypertrophy in spontaneously hypertensive rats. Circ Res 1974; 35: 775-781.
6. Pegram BL, Ishise S, Fröhlich ED: Effect of methyldopa, clonidine and hydralazine on cardiac mass and hemodynamics in Wistar-Kyoto and spontaneusly hypertensive rats. Cardiovasc Res 1982; 16: 40-46.
7. Drayer JIM, Gardin JM, Weber MA, et al: Cardiac muscle during vasodilation therapy of hypertension. Clin Pharmacol Ther 1983; 33: 727-732.
8. Dunn FG, Oigman W, Ventora HO, et al: Enalapril improves systemic and hemodynamics and allows regression of left ventricular mass in essential hypertension. Am J Cardiol 1984; 53: 105-108.
9. Schelling P, Fischer H, Ganten D: Angiotensin and cell growth: A link to cardiovascular hypertrophy. J Hypertens 1991; 9: 3-15.
10. Simpson P: Norepinephrone-stimulated hypertrophy of cultured rat myocardial cells is an alphai adrenergic response. J Clin Invest 1983; 72: 732-738.
11. Ruskoaho H: Prevention of cardiac hypertrophy by long-term treatment with isosorbide dinitrate and prazosin but not minoxidil in spontaneously hypertensive rats. Acta Pharmacol Toxicol 1984; 54: 154-157.
12. Tanaka H, Obata H, Haneda H: Effect of regression of left ventricular hyperterophy following atenolol or bunazosin therapy on ischemic cardiac function and myocardial metabolism in spontaneously hypertensive rats. Jpn Circ J 1991; 55: 1233-1245.
13. Leenen FHH, Smith DL, Farkas RM, et al: Vasodilators and regression of left ventricular hypertrophy: hydralazine versus prazosin in hypertensive humans. Am J Med 1987; 82: 969-978.
14. Burton K: A study of conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 1956; 62: 315-323.
15. Haneda H, Tanaka H, Obata H, et al: Effects of long-term treatment with diltiazem, atenolol and bunazosin on ischemic myocardial metabolism in spontaneously hypertensive rats. Jpn Pharmacol Ther 1990; 18(Suppl): 29-36.
16. 1 blockade does not reverse cardiac hypertrophy in spontaneously hypertensive rats. Jpn Circ J 1993; 57: 898-903.
17. Sen S, Young DR: Role of sodium modulation of myocardial hypertrophy in renal hypertensive rats. Hypertension 1986; 8: 918-924.
18. Mark AL: Sympathetic neural contribution to salt-induced hypertension in Dahl rats. Hypertension 1991; 17(Suppl 1): 86-90.
19. Kunes J, Leontjeva GR, Byskova E, et al: Adrenergic innervation of blood vessels in Dahl rats with salt hypertension. Clin Exp Hypertens [A] 1991; A13: 1343-1355.
20. 125I] IBE 2254. Circ Rec 1982; 51: 250-254.
21. 1-adrenergic receptor interaction. Circ Res 1985; 56: 884-894.
22. 1-adrenoceptor activity in progression of cardiac hypertrophy in guinea pig hearts with pressure overload. Cardiovasc Res 1989; 23: 315-322.
23. Laks MM, Morady F, Swan MB: Myocardial hypertrophy produced by chronic infusion of subhypertensive doses of norepinephrine in the dog. Chest 1973; 64: 75-78.
24. Morkin E, Thomas P: Myocardial DNA synthesis in experimental cadiac hypertrophy. Am J Physiol 1968; 215: 1409-1413.
25. Olivetti G, Ricci R, Anversa P: Hyperplasia of myocyte in long-term cardiac hypertrophy in rats. J Clin Invest 1987; 80: 1818-1821.
26. Tachibana H, Inoue S, Sakai T, et al: Expression of DNA synthetic phase(S-phase) in the cardiomegaly of the spontaneous hypertensive rats(SHR). Jpn Circ J 1990; 54: 800.
27. Sunadresan PR, Fortin TL, Kelvie SL: α- and β-adrenergic receptors in proximal tubules of rat kidney. Am J Physiol 1987; 253: F848-F856.