Genetic modulation of the senescent phenotype of Homo sapiens

Experimental Gerontology

Volumn 31, Issue 1-2, 1996, Pages 49-59

  Martin, George M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

aging; Alzheimer's disease; Homo sapiens; phenotype; senescence; Werner syndrome

Indexed keywords

AMYLOID; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN A; APOLIPOPROTEIN E; DNA; DNA DIRECTED DNA POLYMERASE BETA; GELSOLIN; LIPOFUSCIN; MITOGENIC AGENT;

AGING; ALLELE; ALZHEIMER DISEASE; ATHEROSCLEROSIS; CHROMOSOME; DIABETES MELLITUS; GENE ACTIVITY; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROGERIA; REVIEW; SENESCENCE; WERNER SYNDROME;

EID: 0029970553     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/0531-5565(95)02021-7     Document Type: Article

References (57)

1. ARKING, R. and WELLS, R.A. Genetic alternation of normal aging processes is responsible for extended longevity in Drosophila. Dev. Genet. 11, 141-148, 1990.
2. AYALA, F.J., ESCALANTE, A., O'HUIGIN, C., and KLEIN, J. Molecular genetics of speciation and human origins. Proc. Natl. Acad. Sci. USA 91, 6787-6794, 1994.
3. BIRD, T.D., LAMPE, T.H., NEMENS, E.J., MINER, G.W., SUMI, S.M., and SCHELLENBERG, G.D. Familial Alzheimer's disease in American descendants of the Volga Germans: Probable genetic founder effect. Ann. Neurol. 23, 25-31, 1988.
4. BONNYCASTLE, L.L.C., YU, C.-E., WIJSMAN, E.M., ORR, H.T., PATTERSON, D., CLANCY, K.P., GODDARD, K.A.B., ALONSO, M.E., NEMENS, E., WHITE, J.A., HESTON, L.L., MARTIN, G.M., BIRD, T.D., and SCHELLENBERG, G.D. The c-fos gene and early onset familial Alzheimer's disease. Neurosci. Lett. 160, 33-36, 1993.
5. BONNYCASTLE, L.L.C., YU, C.-E., HUNT, C.R., TRASK, B.J., CLANCY, K.P., WEBER, J.L., PATTERSON, D., and SCHELLENBERG, G.D. Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2). Genomics 23, 85-93, 1994.
6. CHANG, M., BURMER, G.C., SWEASY, J., LOEB, L.A., EDELHOFF, S., DISTECHE, C.M., YU, C.-E., ANDERSON, L., OSHIMA, J., NAKURA, J., MIKI, T., KAMINO, K., OGIHARA, T., SCHELLENBERG, G.D., and MARTIN, G.M. Evidence against DNA polymerase β as a candidate gene for the Werner syndrome. Hum. Genet. 93, 507-512, 1994.
7. CORDER, E.H., SAUNDERS, A.M., STRITTMATTER, W.J., SCHMECHEL, D.E., GASKELL, P.C., SMALL, G.W., ROSES, A.D., HAINES, J.L., and PERICAK-VANCE, M.A. Gene dose of apolipoprotein E type allele and the risk of Alzheimer's disease in late onset families. Science 261, 921-923, 1993.
8. FUKUCHI, K., MARTIN, G.M., and MONNAT, R.J., JR. Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc. Natl. Acad. Sci. USA 86, 5893-5897, 1989.
9. FUKUCHI, K., TANAKA, K., KUMAHARA, Y., MARUMO, K., PRIDE, M.B., MARTIN, G.M., and MONNAT, R.J., JR. Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients. Hum. Genet. 84, 249-252, 1990.
10. FUKUCHI, K., KUNKEL, D.D., SCHWARTZKROIN, P.A., KAMINO, K., OGBURN, C.E., FURLONG, C.E., and MARTIN, G.M. Overexpression of a C-terminal portion of the β-amyloid precursor protein in mouse brains by transplantation of transformed neuronal cells. Exp. Neurol. 127, 253-264, 1994.
11. GERDES, L.U., KLAUSEN, I.C., SIHM, I., and FÆRGEMAN, O. Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world. Genet. Epidemiol. 9, 155-167, 1992.
12. GHISO, J., HALTIA, M., PRELLI, F., NOVELLO, J., and FRANGIONE, B. Gelsolin variant (Asn-187) in familial amyloidosis, Finnish type. Biochem. J. 272, 827-830, 1990.
13. GOATE, A., CHARTIER-HARLIN, M.C., MULLAN, M., BROWN, J., CRAWFORD, F., FIDANI, L., GIUFFRA, L., HAYNES, A., IRVING, N., JAMES, L., MANT, R., NEWTON, P., ROOKE, K., ROQUES, P., TALBOT, C., PERICAK-VANCE, M., ROSES, A., WILLIAMSON, R., ROSSOR, M., OWEN, M., and HARDY, J. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704-706, 1991.
14. GOTO, M., RUBENSTEIN, M., WEBER, J., WOODS, K., and DRAYNA, D. Genetic linkage of Werner's syndrome to five markers on chromosome 8. Nature 355, 735-738, 1992.
15. HARMAN, D. Aging: A theory based on free radical and radiation chemistry. J. Gerontol. 11, 129-135, 1956.
16. HAYFLICK, L. and MOORHEAD, P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621, 1961.
17. HOEHN, H., BRYANT, E.M., AU, K., NORWOOD, T.H., BOMAN, H., and MARTIN, G.M. Variegated translocation mosaicism in human skin fibroblast cultures. Cytogenet. Cell Genet. 15, 282-298, 1975.
18. JAZWINSKI, S.M. The genetics of aging in the yeast Saccharomyces cerevisiae. Genetics 91, 35-51, 1993.
19. JOHNSON, T.E. Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science 249, 908-912, 1990.
20. KAMBOH, M.I., FERRELL, R.E., and KOTTKE, B.A. Expressed hypervariable polymorphism of apolipoprotein (a). Am. J. Hum. Genet. 49, 1063-1074, 1991.
21. KAMINO, K., ORR, H.T., PAYAMI, H., WIJSMAN, E.M., ALONSO, M.E., PULST, S.M., ANDERSON, L., O'DAHL, S., NEMENS, E., WHITE, J.A., SADOVNICK, A.D., BALL, M.J., KAY, J., WARREN, A., MCINNIS, M., ANTONARAKIS, S.E., KORENBERG, J.R., SHARMA, V., KUKULL, W., LARSON, E., HESTON, L.L., MARTIN, G.M., BIRD, T.D., and SCHELLENBERG, G.D. Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region. Am. J. Hum. Genet. 51, 998-1014, 1992.
22. KLEIN, J., TAKAHATA, N., and AYALA, F.J. MHC polymorphism and human origins. Sci. Am. Dec, 78-83, 1993.
23. LAGAAY, A.M., D'AMARO, J., LIGTHART, G.J., SCHREUDER, G.M., VAN ROOD, J.J., and HUMANS, W. Longevity and heredity in humans. Association with the human leucocyte antigen phenotype. Ann. NY Acad. Sci. 621, 78-89, 1991.
24. LUCKINBILL, L.S., RIHA, V., RHINE, S., and GRUDZIEN, T.A. The role of glucose-6-phosphate dehydrogenase in the evolution of longevity in Drosophila melanogaster. Heredity 65, 29-38, 1990.
25. MARTIN, G.M. Genetic syndromes in man with potential relevance to the pathobiology of aging. Birth Defects Orig. Art. Ser. 14, 5-39, 1978.
26. MARTIN, G.M., SPRAGUE, C.A., and EPSTEIN, C.J. Replicative life-span of cultivated human cells: Effects of donor's age, tissue, and genotype. Lab. Invest. 23, 86-92, 1970.
27. MASORO, E.J. Dietary restriction and aging. J. Am. Geriatr. Soc. 41, 994-999, 1993.
28. MULLAN, M., HOULDEN, H., WINDELSPECHT, M., FIDANI, L., LOMBARDI, C., DIAZ, P., ROSSOR, M., CROOK, R., HARDY, J., DUFF, K., and CRAWFORD, F. A locus for familial early onset Alzheimer's disease on the long arm of chromosome 14, proximal to the α1-antichymotrypsin gene. Nat. Genet. 2, 340-342, 1992.
29. NOCHLIN, D., SUMI, S.M., BIRD, T.D. SNOW, A.D., LEVENTHAL, C.M., BEYREUTHER, K., and MASTERS, C.L. Familial dementia with PrP-positive amyloid plaques: A variant of Gerstmann-Straussler syndrome. Neurology 39, 910-918, 1989.
30. ORR, W.C. and SOHAL, R.S. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263, 1128-1130, 1994.
31. OSHIMA, J., YU, C.-E., BOEHNKE, M., WEBER, J.L., EDELHOFF, S., WAGNER, M.J., WELLS, D.E., WOOD, S., DISTECHE, C.M., MARTIN, G.M., and SCHELLENBERG, G.D. Integrated mapping analysis of the Werner syndrome region of chromosome 8. Genomics 23, 100-113, 1994.
32. OSHIMA, J., CAMPISI, J., TANNOCK, T.C.A., and MARTIN, G.M. Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors. J. Cell. Physiol. 162, 277-283, 1995.
33. POOT, M., HOEHN, H., RÜNGER, T.M., and MARTIN, G.M. Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp. Cell Res. 202, 267-273, 1994.
34. REA, I.M. and MIDDLETON, D. Is the phenotypic combination A1B8Cw7DR3 a marker for male longevity? J. Am. Geriatr. Soc. 42, 978-983, 1994.
35. ROGAEV, E.I., LUKIW, W.J., VAULA, G., HAINES, J.L., ROGAEVA, E.A., TSUDA, T., ALEXANDROVA, N., LIANG, Y., MORTILLA, M., AMADUCCI, L., BERGAMINI, L., BRUNI, A.C., FONCIN, J.-F., MACCIARDI, F., MONTESI, M.P., SORBI, S., RAINERO, I., PINESSI, L., POLINSKY, R.J., FROMMELT, P., DUARA, R., LOPEZ, R., POLLEN, D., GUSELLA, J.F., TANZI, R., CRAPPER MACLACHLAN, D., AND ST. GEORGE-HYSLOP, P.H. Analysis of the c-fos gene on chromosome 14 and the promoter of the amyloid precursor protein gene in familial Alzheimer's disease. Neurology 43, 2275-2279, 1993.
36. ROSE, M.R. Evolutionary Biology of Aging, Oxford University Press, New York, 1991.
37. RUNGER, T.M., BAUER, C., DEKANT, B., MÖLLER, K., SOBOTTA, P., CZERNY, C., POOT, M., and MARTIN, G.M. Hypermutable ligation of plasmid DNA ends in cells from patients with Werner syndrome. J. Invest. Dermatol. 102, 45-48, 1994.
38. SACK, G.H., JR., DUMARS, K.W., GUMMERSON, K.S., LAW, A., and MCKUSICK, V.A. Three forms of dominant amyloid neuropathy. Johns Hopkins Med. J. 149, 239-247, 1981.
39. SADAKANE, Y., MAEDA, K., KURODA, Y., and HORI, K. Identification of mutations in DNA polymerase beta mRNAs from patients with Werner syndrome. Biochem. Biophys. Res. Commun. 200, 219-225, 1994.
40. SALK, D., AU, K., HOEHN, H., and MARTIN, G.M. Cytogenetics of Werner's syndrome cultured skin fibroblasts: Variegated translocation mosaicism. Cytogenet. Cell Genet. 30, 92-107, 1981.
41. SCHÄCHTER, F., FAURE-DELANEF, L., GUÉNOT, F., ROUGER, H., FROGUEL, P., LESUEUR-GINOT, L., and COHEN, D. Genetic associations with human longevity at the APOE and ACE loci. Nat. Genet. 6, 29-32, 1994.
42. SCHELLENBERG, G.D., DEEB, S.S., BOEHNKE, M., BRYANT, E.M., MARTIN, G.M., LAMPE, T.H., and BIRD, T.D. Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type. J. Neurogenet. 4, 97-108, 1987.
43. 693, and PRIP gene mutations are rare in Alzheimer's disease. Am. J. Hum. Genet. 49, 511-517, 1991.
44. SCHELLENBERG, G.D., BIRD, T.D., WIJSMAN, E.M., ORR, H.T., ANDERSON, L., NEMENS, E., WHITE, J.A., BONNYCASTLE, L., WEBER, J.L., ALONSO, M.E., POTTER, H., HESTON, L.L., and MARTIN, G.M. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 258, 668-671, 1992a.
45. SCHELLENBERG, G.D., BOEHNKE, M., WIJSMAN, E.M., MOORE, D.K., MARTIN, G.M., and BIRD, T.D. Genetic association and linkage analysis of the apolipoprotein CII locus and familial Alzheimer's disease. Ann. Neurol. 31, 223-227, 1992b.
46. SCHELLENBERG, G.D., MARTIN, G.M., WIJSMAN, E.M., NAKURA, J., MIKI, T., and OGIHARA, T. Homozygosity mapping and Werner's syndrome (letter). Lancet 339, 1002, 1992c.
47. SOPHER, B.L., FUKUCHI, K., SMITH, A.C., LEPPIG, K.A., FURLONG, C.E., and MARTIN, G.M. Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the β-amyloid precursor protein. Mol. Brain Res. 26, 207-217, 1994.
48. ST. GEORGE-HYSLOP, P., HAINES, J., ROGAEV, E., MORTILLA, M., VAULA, G., PERICAK-VANCE, M., FONCIN, J.-F., MONTESI, M., BRUNI, A., SORBI, S., RAINERO, I., PINESSI, L., POLLEN, D., POLINSKY, R., NEE, L., KENNEDY, J., MACCIARDI, F., ROGAEVA, E., LIANG, Y., ALEXANDROVA, N., LUKIW, W., SCHLUMPF, K., TANZI, R., TSUDA, T., FARRER, L., CANTU, J.-M., DUARA, R., AMADUCCI, L., BERGAMINI, L., GUSELLA, J., ROSES, A., and CRAPPER MCLACHLAN, D. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nat. Genet. 2, 330-334, 1992.
49. STRITTMATTER, W.J., SAUNDERS, A.M., SCHMECHEL, D., PERICAK-VANCE, M., ENGHILD, J., SALVESEN, G.S., and ROSES, A.D. Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. USA 90, 1977-1981, 1993.
50. SUMI, S.M., BIRD, T.D., NOCHLIN, D., and RASKIND, M.A. Familial presenile dementia with psychosis associated with cortical neurofibrillary tangles and degeneration of the amygdala. Neurology 42, 120-127, 1992.
51. TAKAHASHI, J.S., PINTO, L.H., and VITATERNA, M.H. Forward and reverse genetic approaches to behavior in the mouse. Science 264, 1724-1733, 1994.
52. TAKATA, H., SUZUKI, M., ISHII, T., SEKIGUCHI, S., and IRI, H. Influence of major histocompatibility complex region genes on human longevity among Okinawan-Japanese centenarians and nonagenarians. Lancet 2(8563), 824-826, 1987.
53. TANZI, R.E., VAULA, G., ROMANO, D.M., MORTILLA, M., HUANG, T.L., TUPLER, R.G., WASCO, W., HYMAN, B.T., HAINES, J.L., JENKINS, B.J., KALAITSIDAKI, M., WARREN, A.C., MCINNIS, M.C., ANTONARKIS, S.E., KARLINSKY, H., PERCY, M.E., CONNOR, L., GROWDON, J., CRAPPER-MCLACHLAN, D.R., GUSELLA, J.F., and ST. GEORGE-HYSLOP, P.H. Assessment of amyloid β-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. Am. J. Hum. Genet. 51, 273-282, 1992.
54. VAN BROECKHOVEN, C., BACKHOVENS, H., CRUTS, M., DE WINTER, G., BRUYLAND, M., CRAS, P., and MARTIN, J.-J. Mapping of a gene predisposing to early onset Alzheimer's disease to chromosome 14q24.3. Nature Genet. 2, 335-339, 1992.
55. WAINSCOAT, J.S., PETO, T.E., and WASWO, A. HLA genes and longevity. Lancet 2(8572), 1399, 1987.
56. WEINDRUCH, R. and WALFORD R.L. The Retardation of Aging and Disease by Dietary Restriction, Charles C. Thomas, Springfield, IL, 1988.
57. YU, C.-E., OSHIMA, J., GODDARD, K.A.B., MIKI, T., NAKURA, J., OGIHARA, T., POOT, M., HOEHN, H., FRACCARO, M., PIUSSAN, C., MARTIN, G.M., SCHELLENBERG, G.D., and WIJSMAN, E.M. Linkage disequilibrium and haplotype studies of chromosome 8p 11.1-21.1 markers and Werner syndrome. Am. J. Hum. Genet. 55, 356-364, 1994.