Measurement of serum acetylsalicylic acid in a porcine model of aspirin overdose

Veterinary and Human Toxicology

Volumn 38, Issue 6, 1996, Pages 409-412

  Eppler, Jeffrey ^a   Johnson, David ^b   Verjee, Zul ^c   Giesbrecht, Esther ^c   Ito, Shinya ^c  

^a KELOWNA GENERAL HOSPITAL   (Canada)

^b ALBERTA CHILDREN'S HOSPITAL   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID;

ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG OVERDOSE; NONHUMAN; SWINE;

ADMINISTRATION, ORAL; ANIMALS; ASPIRIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEASIBILITY STUDIES; HYDROLYSIS; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; OVERDOSE; SWINE;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 0029969831     PISSN: 01456296     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Levy G, Leonards JR: Absorption, metabolism and excretion of salicylates. In Smith MJH, Smith PK eds: The Salicylates. Interscience, New York: 5-25, 1966.
2. Smith MJH, Irving JD: The effect of salicylate on the passage of a barium meal in the rat. Br J Radiol 28: 39-41, 1955.
3. Matthew H, MacKintosh TF, Tompsett SL et al: Gastric aspiration and lavage in acute poisoning. Br Med J 1: 1333-1337, 1966.
4. Done AK: Treatment of salicylate poisoning: Review of personal and published experiences. Clin Tox 1: 451-467, 1968.
5. McGuigan MA: A two-year review of salicylate deaths in Ontario. Arch Intern Med 147: 510-512, 1987.
6. Ho JL, Tierney MG, Dickinson GE: An evaluation of the effect of repeated doses of oral activated charcoal on salicylate elimination. J Clin Pharmacol 29: 366-369, 1989.
7. Kirshenbaum LA, Mathews SC, Sitar DS et al: Does multiple-dose charcoal therapy enhance salicylate elimination? Arch Intern Med 150: 1281-1283, 1990.
8. Kirshenbaum LA, Mathews SC, Sitar DS et al: Whole bowel irrigation versus activated charcoal in sorbitol for the ingestion of modified-release pharmaceuticals. Clin Pharmacol Ther 46: 264-271, 1989.
9. Mayer AL, Sitar DS, Tenenbein H: Multiple-dose charcoal and whole-bowel irrigation do not increase clearance of absorbed salicylate. Arch Intern Med 152: 393-396, 1992.
10. Benet LZ, Sheiner LB: Pharmacokinetics: The dynamics of drug absorption, distribution and elimination. In Gilman AC, Goodman LS, Rall TW et al eds: Goodman and Gilman's The Pharmacologic Basis of Therapeutics, 7th ed. Macmillan, New York: 23-41, 1985.